Serum parathyroid hormone and 25-hydroxyvitamin D concentrations and risk of incident heart failure: the Multi-Ethnic Study of Atherosclerosis.
Bottom Line: Compared with participants with PTH <65 pg/mL, PTH ≥65 pg/mL was associated with a 50% greater risk of incident HF (95% CI: 3% to 210%) and a 5.3 g higher left ventricular mass (95% CI: 2.6, 7.9 g).In contrast, there was no association of 25(OH)D with risk of incident HF or elevated left ventricular mass.Further studies should be pursued to determine whether PTH excess may be a modifiable risk factor for HF.
Affiliation: Kidney Research Institute, University of Washington, Seattle, WA (N.B., L.Z., C.R.C., A.N.H., B.K., I.H.B.).Show MeSH
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Mentions: In multivariable models (model 3) stratified by important participant characteristics, the difference in LVM in participants with high PTH was stronger in Chinese participants, and those with eGFR <60 mL/min per 1.73 m2, although the interactions for these characteristics were not statistically significant (P>0.05). However, the difference in LVM in participants with high PTH was significantly stronger in men versus women (Figure 5).
Affiliation: Kidney Research Institute, University of Washington, Seattle, WA (N.B., L.Z., C.R.C., A.N.H., B.K., I.H.B.).