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Serum parathyroid hormone and 25-hydroxyvitamin D concentrations and risk of incident heart failure: the Multi-Ethnic Study of Atherosclerosis.

Bansal N, Zelnick L, Robinson-Cohen C, Hoofnagle AN, Ix JH, Lima JA, Shoben AB, Peralta CA, Siscovick DS, Kestenbaum B, de Boer IH - J Am Heart Assoc (2014)

Bottom Line: Compared with participants with PTH <65 pg/mL, PTH ≥65 pg/mL was associated with a 50% greater risk of incident HF (95% CI: 3% to 210%) and a 5.3 g higher left ventricular mass (95% CI: 2.6, 7.9 g).In contrast, there was no association of 25(OH)D with risk of incident HF or elevated left ventricular mass.Further studies should be pursued to determine whether PTH excess may be a modifiable risk factor for HF.

View Article: PubMed Central - PubMed

Affiliation: Kidney Research Institute, University of Washington, Seattle, WA (N.B., L.Z., C.R.C., A.N.H., B.K., I.H.B.).

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Association* of high parathyroid hormone (≥65 pg/mL vs <65 pg/mL) with left ventricular mass in important subgroups in the Multi‐Ethnic Study of Atherosclerosis (N=4763). *Adjusted for age, sex, race/ethnicity, education, height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, SBP, antihypertensive medications, calcium, phosphorus, and 25(OH)D. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure.
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fig05: Association* of high parathyroid hormone (≥65 pg/mL vs <65 pg/mL) with left ventricular mass in important subgroups in the Multi‐Ethnic Study of Atherosclerosis (N=4763). *Adjusted for age, sex, race/ethnicity, education, height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, SBP, antihypertensive medications, calcium, phosphorus, and 25(OH)D. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure.

Mentions: In multivariable models (model 3) stratified by important participant characteristics, the difference in LVM in participants with high PTH was stronger in Chinese participants, and those with eGFR <60 mL/min per 1.73 m2, although the interactions for these characteristics were not statistically significant (P>0.05). However, the difference in LVM in participants with high PTH was significantly stronger in men versus women (Figure 5).


Serum parathyroid hormone and 25-hydroxyvitamin D concentrations and risk of incident heart failure: the Multi-Ethnic Study of Atherosclerosis.

Bansal N, Zelnick L, Robinson-Cohen C, Hoofnagle AN, Ix JH, Lima JA, Shoben AB, Peralta CA, Siscovick DS, Kestenbaum B, de Boer IH - J Am Heart Assoc (2014)

Association* of high parathyroid hormone (≥65 pg/mL vs <65 pg/mL) with left ventricular mass in important subgroups in the Multi‐Ethnic Study of Atherosclerosis (N=4763). *Adjusted for age, sex, race/ethnicity, education, height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, SBP, antihypertensive medications, calcium, phosphorus, and 25(OH)D. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4338718&req=5

fig05: Association* of high parathyroid hormone (≥65 pg/mL vs <65 pg/mL) with left ventricular mass in important subgroups in the Multi‐Ethnic Study of Atherosclerosis (N=4763). *Adjusted for age, sex, race/ethnicity, education, height, weight, smoking, physical activity level, diabetes, eGFR, urine ACR, SBP, antihypertensive medications, calcium, phosphorus, and 25(OH)D. ACR indicates albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure.
Mentions: In multivariable models (model 3) stratified by important participant characteristics, the difference in LVM in participants with high PTH was stronger in Chinese participants, and those with eGFR <60 mL/min per 1.73 m2, although the interactions for these characteristics were not statistically significant (P>0.05). However, the difference in LVM in participants with high PTH was significantly stronger in men versus women (Figure 5).

Bottom Line: Compared with participants with PTH <65 pg/mL, PTH ≥65 pg/mL was associated with a 50% greater risk of incident HF (95% CI: 3% to 210%) and a 5.3 g higher left ventricular mass (95% CI: 2.6, 7.9 g).In contrast, there was no association of 25(OH)D with risk of incident HF or elevated left ventricular mass.Further studies should be pursued to determine whether PTH excess may be a modifiable risk factor for HF.

View Article: PubMed Central - PubMed

Affiliation: Kidney Research Institute, University of Washington, Seattle, WA (N.B., L.Z., C.R.C., A.N.H., B.K., I.H.B.).

Show MeSH
Related in: MedlinePlus