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Associations of three well-characterized polymorphisms in the IL-6 and IL-10 genes with pneumonia: a meta-analysis.

Chen H, Li N, Wan H, Cheng Q, Shi G, Feng Y - Sci Rep (2015)

Bottom Line: Analyses of the full data set failed to identify any significant association of pneumonia risk with the IL-6 gene -174C allele (OR = 1.00; 95% CI: 0.98-1.03), the IL-10 gene -592C allele (OR = 1.20; 95% CI: 0.95-1.52), or the IL-10 gene -1082A allele (OR = 1.21; 95% CI: 0.99-1.49).There was a low probability of publication bias, as reflected by the fail-safe number.This meta-analysis suggests that there is no significantly increased risk of pneumonia associated with previously reported IL-6 and IL-10 polymorphisms.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiration, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT
Published data on the associations between three well-characterized polymorphisms in the interleukin 6 and 10 (IL-6 and IL-10) genes and the risk of pneumonia are inconclusive. A meta-analysis was performed to derive a more precise estimate. The electronic databases MEDLINE (Ovid) and PubMed were searched from the earliest possible year to May 2014. A total of 9 articles met the criteria, and these included 3460 patients with pneumonia and 3037 controls. The data were analyzed with RevMan software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses of the full data set failed to identify any significant association of pneumonia risk with the IL-6 gene -174C allele (OR = 1.00; 95% CI: 0.98-1.03), the IL-10 gene -592C allele (OR = 1.20; 95% CI: 0.95-1.52), or the IL-10 gene -1082A allele (OR = 1.21; 95% CI: 0.99-1.49). In a subgroup analysis by pneumonia type, ethnicity, sample size and quality score, no significantly increased risk of pneumonia was found for individuals carrying the IL-6 gene -174C allele. There was a low probability of publication bias, as reflected by the fail-safe number. This meta-analysis suggests that there is no significantly increased risk of pneumonia associated with previously reported IL-6 and IL-10 polymorphisms.

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Related in: MedlinePlus

Flow diagram of the search strategy and study selection.
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f1: Flow diagram of the search strategy and study selection.

Mentions: Based on the search strategy, our primary search produced 39 potentially relevant articles, of which 9 articles met the inclusion criteria67891011121314. In total, 3460 patients with pneumonia and 3037 controls were examined. The detailed selection process is presented in Figure 1. The details of each excluded study have been uploaded as a supplementary information file (Table S2). The baseline characteristics of the included studies are presented in Table 1.


Associations of three well-characterized polymorphisms in the IL-6 and IL-10 genes with pneumonia: a meta-analysis.

Chen H, Li N, Wan H, Cheng Q, Shi G, Feng Y - Sci Rep (2015)

Flow diagram of the search strategy and study selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4338428&req=5

f1: Flow diagram of the search strategy and study selection.
Mentions: Based on the search strategy, our primary search produced 39 potentially relevant articles, of which 9 articles met the inclusion criteria67891011121314. In total, 3460 patients with pneumonia and 3037 controls were examined. The detailed selection process is presented in Figure 1. The details of each excluded study have been uploaded as a supplementary information file (Table S2). The baseline characteristics of the included studies are presented in Table 1.

Bottom Line: Analyses of the full data set failed to identify any significant association of pneumonia risk with the IL-6 gene -174C allele (OR = 1.00; 95% CI: 0.98-1.03), the IL-10 gene -592C allele (OR = 1.20; 95% CI: 0.95-1.52), or the IL-10 gene -1082A allele (OR = 1.21; 95% CI: 0.99-1.49).There was a low probability of publication bias, as reflected by the fail-safe number.This meta-analysis suggests that there is no significantly increased risk of pneumonia associated with previously reported IL-6 and IL-10 polymorphisms.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiration, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT
Published data on the associations between three well-characterized polymorphisms in the interleukin 6 and 10 (IL-6 and IL-10) genes and the risk of pneumonia are inconclusive. A meta-analysis was performed to derive a more precise estimate. The electronic databases MEDLINE (Ovid) and PubMed were searched from the earliest possible year to May 2014. A total of 9 articles met the criteria, and these included 3460 patients with pneumonia and 3037 controls. The data were analyzed with RevMan software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses of the full data set failed to identify any significant association of pneumonia risk with the IL-6 gene -174C allele (OR = 1.00; 95% CI: 0.98-1.03), the IL-10 gene -592C allele (OR = 1.20; 95% CI: 0.95-1.52), or the IL-10 gene -1082A allele (OR = 1.21; 95% CI: 0.99-1.49). In a subgroup analysis by pneumonia type, ethnicity, sample size and quality score, no significantly increased risk of pneumonia was found for individuals carrying the IL-6 gene -174C allele. There was a low probability of publication bias, as reflected by the fail-safe number. This meta-analysis suggests that there is no significantly increased risk of pneumonia associated with previously reported IL-6 and IL-10 polymorphisms.

Show MeSH
Related in: MedlinePlus