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Clinical and Oncological Value of Preoperative BMI in Gastric Cancer Patients: A Single Center Experience.

Voglino C, Di Mare G, Ferrara F, De Franco L, Roviello F, Marrelli D - Gastroenterol Res Pract (2015)

Bottom Line: Results.No significant correlations between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, surgical results, lymph node dissection, and postoperative morbidity and mortality were observed.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Surgery and Neurosciences, Unit of General Surgery and Surgical Oncology, University of Siena, Policlinico "Le Scotte", Viale Bracci, 53100 Siena, Italy.

ABSTRACT
Introduction. The impact of preoperative BMI on surgical outcomes and long-term survival of gastric cancer patients was investigated in various reports with contrasting results. Materials & Methods. A total of 378 patients who underwent a surgical resection for primary gastric cancer between 1994 and 2011 were retrospectively studied. Patients were stratified according to BMI into a normal group (<25, group A), an overweight group (25-30, group B), and an obesity group (≥30, group C). These 3 groups were compared according to clinical-pathological characteristics, surgical treatment, and long-term survival. Results. No significant correlations between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, surgical results, lymph node dissection, and postoperative morbidity and mortality were observed. Factors related to higher BMI were male gender (P < 0.05), diabetes (P < 0.001), and serum blood proteins (P < 0.01). A trend to fewer lymph nodes retrieved during gastrectomy with lymphadenectomy in overweight patients (B and C groups) was observed, although not statistically significant. There was no difference in overall survival or disease-specific survival between the three groups. Conclusion. According to our data, BMI should not be considered a significant predictor of postoperative complications or long-term result in gastric cancer patients.

No MeSH data available.


Related in: MedlinePlus

Correlation between BMI and number of lymph nodes harvested (P = 0.055).
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fig2: Correlation between BMI and number of lymph nodes harvested (P = 0.055).

Mentions: Preoperatively, higher BMI was associated with male gender (P < 0.05), type 2 diabetes (P < 0.001) (Table 1), and serum blood proteins (P < 0.01) (Figure 1). No significant relationships were found between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, tumor site, major morbidity, and hospital stay. A trend to fewer retrieved lymph nodes was observed in overweight patients (B and C groups), as the median number of lymph nodes examined was 37 for group A (range 3–140), 33 for group B (range 5–108), and 35 for group C (range 4–68) (P = 0.059 Kruskal-Wallis). This difference was also not statistically significant when correlation analysis was used (P = 0.055) (Figure 2). The median number of metastatic lymph nodes was 4 for group A (range 0–86), 3 for group B (range 0–55), and 5 for group C (range 0–63) (P = 0.586).


Clinical and Oncological Value of Preoperative BMI in Gastric Cancer Patients: A Single Center Experience.

Voglino C, Di Mare G, Ferrara F, De Franco L, Roviello F, Marrelli D - Gastroenterol Res Pract (2015)

Correlation between BMI and number of lymph nodes harvested (P = 0.055).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4338394&req=5

fig2: Correlation between BMI and number of lymph nodes harvested (P = 0.055).
Mentions: Preoperatively, higher BMI was associated with male gender (P < 0.05), type 2 diabetes (P < 0.001) (Table 1), and serum blood proteins (P < 0.01) (Figure 1). No significant relationships were found between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, tumor site, major morbidity, and hospital stay. A trend to fewer retrieved lymph nodes was observed in overweight patients (B and C groups), as the median number of lymph nodes examined was 37 for group A (range 3–140), 33 for group B (range 5–108), and 35 for group C (range 4–68) (P = 0.059 Kruskal-Wallis). This difference was also not statistically significant when correlation analysis was used (P = 0.055) (Figure 2). The median number of metastatic lymph nodes was 4 for group A (range 0–86), 3 for group B (range 0–55), and 5 for group C (range 0–63) (P = 0.586).

Bottom Line: Results.No significant correlations between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, surgical results, lymph node dissection, and postoperative morbidity and mortality were observed.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Surgery and Neurosciences, Unit of General Surgery and Surgical Oncology, University of Siena, Policlinico "Le Scotte", Viale Bracci, 53100 Siena, Italy.

ABSTRACT
Introduction. The impact of preoperative BMI on surgical outcomes and long-term survival of gastric cancer patients was investigated in various reports with contrasting results. Materials & Methods. A total of 378 patients who underwent a surgical resection for primary gastric cancer between 1994 and 2011 were retrospectively studied. Patients were stratified according to BMI into a normal group (<25, group A), an overweight group (25-30, group B), and an obesity group (≥30, group C). These 3 groups were compared according to clinical-pathological characteristics, surgical treatment, and long-term survival. Results. No significant correlations between BMI and TNM (2010), UICC stage (2010), Lauren's histological type, surgical results, lymph node dissection, and postoperative morbidity and mortality were observed. Factors related to higher BMI were male gender (P < 0.05), diabetes (P < 0.001), and serum blood proteins (P < 0.01). A trend to fewer lymph nodes retrieved during gastrectomy with lymphadenectomy in overweight patients (B and C groups) was observed, although not statistically significant. There was no difference in overall survival or disease-specific survival between the three groups. Conclusion. According to our data, BMI should not be considered a significant predictor of postoperative complications or long-term result in gastric cancer patients.

No MeSH data available.


Related in: MedlinePlus