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Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.

Jagodzinska J, Polaniak R, Birkner E, Kasperska-Zajac A - Biomed Res Int (2015)

Bottom Line: Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups.Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH.Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Anaesthesiology and Intensive Therapy, Upper Silesian Medical Centre, 40-635 Katowice, Poland.

ABSTRACT

Background: Vascular endothelial growth factor (VEGF) is a powerful enhancer of vascular permeability and inflammatory response; however its significance in chronic urticaria is poorly recognised.

Aim: To compare free circulating levels of VEGF and its soluble receptors (sVEGFR1 and VEGFR2) in patients with different forms of chronic urticaria.

Methods: The concentrations of VEGF and its receptors in plateletpoor plasma (PPP)/plasma were measured using enzyme-linked immunosorbent assay in chronic urticaria: (1) chronic spontaneous urticaria (CSU) with positive autologous serum skin test (ASST), (2) CSU with negative response to ASST, (3) CSU with concomitant euthyroid Hashimoto's thyroiditis (CSU/Hashimoto), (4) delayed pressure urticaria (DPU), and the healthy subjects.

Results: There were no significant differences in VEGF concentration in PPP between CSU groups and the healthy subjects. Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups. Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH. Plasma concentrations of sVEGF1 and sVEGF2 were similar in chronic urticaria patients and the healthy subjects.

Conclusions: Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto's thyroiditis.

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Related in: MedlinePlus

Changes in plasma VEGF concentration in CSU/ASST(+)/Hashimoto patients during the active phase in comparison to the remission phase (P = 0.656).
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fig1: Changes in plasma VEGF concentration in CSU/ASST(+)/Hashimoto patients during the active phase in comparison to the remission phase (P = 0.656).

Mentions: There were no significant differences in VEGF concentration between CSU/ASST(−), CSU/ASST(+), and the healthy subjects (Table 2). Contrary, VEGF concentration was significantly higher in DPU and CSU/ASST(+)/Hashimoto groups as compared with the healthy subjects and CSU groups (Table 2). Furthermore, VEGF value in PPP of CSU/ASST(+)/Hashimoto subgroup during the remission period was similar to that of the active period (median: 28.4 versus 35.8; P > 0.05; Figure 1) and significantly higher than the healthy subjects (median: 28.4 versus 18.4 pg/mL; P < 0.05).


Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.

Jagodzinska J, Polaniak R, Birkner E, Kasperska-Zajac A - Biomed Res Int (2015)

Changes in plasma VEGF concentration in CSU/ASST(+)/Hashimoto patients during the active phase in comparison to the remission phase (P = 0.656).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4338375&req=5

fig1: Changes in plasma VEGF concentration in CSU/ASST(+)/Hashimoto patients during the active phase in comparison to the remission phase (P = 0.656).
Mentions: There were no significant differences in VEGF concentration between CSU/ASST(−), CSU/ASST(+), and the healthy subjects (Table 2). Contrary, VEGF concentration was significantly higher in DPU and CSU/ASST(+)/Hashimoto groups as compared with the healthy subjects and CSU groups (Table 2). Furthermore, VEGF value in PPP of CSU/ASST(+)/Hashimoto subgroup during the remission period was similar to that of the active period (median: 28.4 versus 35.8; P > 0.05; Figure 1) and significantly higher than the healthy subjects (median: 28.4 versus 18.4 pg/mL; P < 0.05).

Bottom Line: Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups.Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH.Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto's thyroiditis.

View Article: PubMed Central - PubMed

Affiliation: Anaesthesiology and Intensive Therapy, Upper Silesian Medical Centre, 40-635 Katowice, Poland.

ABSTRACT

Background: Vascular endothelial growth factor (VEGF) is a powerful enhancer of vascular permeability and inflammatory response; however its significance in chronic urticaria is poorly recognised.

Aim: To compare free circulating levels of VEGF and its soluble receptors (sVEGFR1 and VEGFR2) in patients with different forms of chronic urticaria.

Methods: The concentrations of VEGF and its receptors in plateletpoor plasma (PPP)/plasma were measured using enzyme-linked immunosorbent assay in chronic urticaria: (1) chronic spontaneous urticaria (CSU) with positive autologous serum skin test (ASST), (2) CSU with negative response to ASST, (3) CSU with concomitant euthyroid Hashimoto's thyroiditis (CSU/Hashimoto), (4) delayed pressure urticaria (DPU), and the healthy subjects.

Results: There were no significant differences in VEGF concentration in PPP between CSU groups and the healthy subjects. Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups. Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH. Plasma concentrations of sVEGF1 and sVEGF2 were similar in chronic urticaria patients and the healthy subjects.

Conclusions: Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto's thyroiditis.

Show MeSH
Related in: MedlinePlus