Interaction of micron and nano-sized particles with cells of the dura mater.
Bottom Line: The adverse effects of TDR wear have the potential to manifest in the dura mater and surrounding tissues.However, dural fibroblasts engulfed micron-sized particles at a much higher rate than dural epithelial cells.The study suggested that dural epithelial cells may offer some barrier to the penetration of micron-sized particles but not nanometer sized particles.
Affiliation: Institute of Medical & Biological Engineering (IMBE), Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.Show MeSH
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Mentions: The capacity of the dural cells to internalize micron (1 µm) and nano-sized (40 nm) particles was assessed over a period of 1 and 3 days. Representative examples of particle uptake are shown in Figures 3 and Figure 5 for the micron and nano-sized particles respectively.
Affiliation: Institute of Medical & Biological Engineering (IMBE), Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.