Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release.
Bottom Line: Here, we show that depleting microglia from hippocampal cultures reduces NSPC survival and proliferation.VIP, a neuropeptide released by dentate gyrus interneurons, enhances the proliferative and pro-neurogenic effect of microglia via the VPAC1 receptor.This VIP-induced enhancement is mediated by IL-4 release, which directly targets NSPCs.
Affiliation: Division of Clinical Neurosciences, University of Southampton, Southampton, United Kingdom.Show MeSH
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Mentions: VIP at physiological concentrations (nM) is known to act through the high affinity receptors VPAC1 and VPAC2 receptors (Harmar et al., 1998; Zaben et al., 2009). Using real-time PCR we have shown that VPAC1, but not VPAC2, receptor mRNA is expressed in postnatal hippocampal microglial cultures (Fig. 5A).
Affiliation: Division of Clinical Neurosciences, University of Southampton, Southampton, United Kingdom.