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Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography.

Monti L, Donati D, Menci E, Cioni S, Bellini M, Grazzini I, Leonini S, Galluzzi P, Bracco S, Severi S, Burroni L, Casasco A, Morbidelli L, Santarnecchi E, Piu P - PLoS ONE (2015)

Bottom Line: No significant statistical correlation was found between CCT and the other parameters in all MS patients.Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings.Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.

View Article: PubMed Central - PubMed

Affiliation: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.

ABSTRACT
Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.

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Related in: MedlinePlus

The plots in the panels indicate the close similarity between the CCT evaluations by rater and side.Upper panels: the CCT measurements at the right and left side ICA across the subjects in the control group evaluated by first rater (left panel) and second rater (right panel).
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pone.0116681.g002: The plots in the panels indicate the close similarity between the CCT evaluations by rater and side.Upper panels: the CCT measurements at the right and left side ICA across the subjects in the control group evaluated by first rater (left panel) and second rater (right panel).

Mentions: Reproducibility assessments of the CCT measurements by means of the ICC3,1 were calculated for the control group in the right side (ICC3,1 = 0.934; 95%CI = [0.882:0.963]), for the control group in the left side (ICC3,1 = 0.897; 95%CI = [0.819:0.943]), for the MS group in the right side (ICC3,1 = 0.984; 95%CI = [0.974:0.989]) and for the MS group in the left side (ICC3,1 = 0.984; 95%CI = [0.975–0.989]). These findings indicated either strong or almost complete agreement between the two neuroradiologists who performed the CCT evaluations. (Fig. 2)


Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography.

Monti L, Donati D, Menci E, Cioni S, Bellini M, Grazzini I, Leonini S, Galluzzi P, Bracco S, Severi S, Burroni L, Casasco A, Morbidelli L, Santarnecchi E, Piu P - PLoS ONE (2015)

The plots in the panels indicate the close similarity between the CCT evaluations by rater and side.Upper panels: the CCT measurements at the right and left side ICA across the subjects in the control group evaluated by first rater (left panel) and second rater (right panel).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4334558&req=5

pone.0116681.g002: The plots in the panels indicate the close similarity between the CCT evaluations by rater and side.Upper panels: the CCT measurements at the right and left side ICA across the subjects in the control group evaluated by first rater (left panel) and second rater (right panel).
Mentions: Reproducibility assessments of the CCT measurements by means of the ICC3,1 were calculated for the control group in the right side (ICC3,1 = 0.934; 95%CI = [0.882:0.963]), for the control group in the left side (ICC3,1 = 0.897; 95%CI = [0.819:0.943]), for the MS group in the right side (ICC3,1 = 0.984; 95%CI = [0.974:0.989]) and for the MS group in the left side (ICC3,1 = 0.984; 95%CI = [0.975–0.989]). These findings indicated either strong or almost complete agreement between the two neuroradiologists who performed the CCT evaluations. (Fig. 2)

Bottom Line: No significant statistical correlation was found between CCT and the other parameters in all MS patients.Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings.Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.

View Article: PubMed Central - PubMed

Affiliation: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.

ABSTRACT
Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.

Show MeSH
Related in: MedlinePlus