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Giant congenital melanocytic nevi and neurocutaneous melanosis.

Araújo C, Resende C, Pardal F, Brito C - Case Rep Med (2015)

Bottom Line: Discussion.This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration.Diffuse spinal involvement is unusual and is described in only another patient.

View Article: PubMed Central - PubMed

Affiliation: Dermatology Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, Portugal.

ABSTRACT
Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.

No MeSH data available.


Related in: MedlinePlus

Giant black-brown pigmented nevus, one covering nearly the entire right thoracodorsal region and the other on the left thigh. Note also satellite nevi on the trunk and extremities.
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fig1: Giant black-brown pigmented nevus, one covering nearly the entire right thoracodorsal region and the other on the left thigh. Note also satellite nevi on the trunk and extremities.

Mentions: A 30-year-old woman presented with impaired vision, dizziness, and headache for one week prior to admission. Physical examination revealed many brownish-black nevi on the trunk, including a giant one covering nearly the entire right thoracodorsal region (32 cm × 20 cm) and another on the left thigh (25 × 18 cm) (Figure 1). Another cephalic patch (5 cm × 4 cm) was situated on the frontal region and many brownish-black nevi on the lower limb some with abundant hair that appeared during the first years of life. Most nevi were irregular but showed no clinical signs of malignancy.


Giant congenital melanocytic nevi and neurocutaneous melanosis.

Araújo C, Resende C, Pardal F, Brito C - Case Rep Med (2015)

Giant black-brown pigmented nevus, one covering nearly the entire right thoracodorsal region and the other on the left thigh. Note also satellite nevi on the trunk and extremities.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4334432&req=5

fig1: Giant black-brown pigmented nevus, one covering nearly the entire right thoracodorsal region and the other on the left thigh. Note also satellite nevi on the trunk and extremities.
Mentions: A 30-year-old woman presented with impaired vision, dizziness, and headache for one week prior to admission. Physical examination revealed many brownish-black nevi on the trunk, including a giant one covering nearly the entire right thoracodorsal region (32 cm × 20 cm) and another on the left thigh (25 × 18 cm) (Figure 1). Another cephalic patch (5 cm × 4 cm) was situated on the frontal region and many brownish-black nevi on the lower limb some with abundant hair that appeared during the first years of life. Most nevi were irregular but showed no clinical signs of malignancy.

Bottom Line: Discussion.This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration.Diffuse spinal involvement is unusual and is described in only another patient.

View Article: PubMed Central - PubMed

Affiliation: Dermatology Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, Portugal.

ABSTRACT
Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.

No MeSH data available.


Related in: MedlinePlus