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Improving intranasal delivery of neurological nanomedicine to the olfactory region using magnetophoretic guidance of microsphere carriers.

Xi J, Zhang Z, Si XA - Int J Nanomedicine (2015)

Bottom Line: It is crucial to developing new methods that can deliver drug particles more effectively to the olfactory region.The optimal particle size was found to be approximately 15 μm for effective magnetophoretic guidance while avoiding loss of particles to the walls in the anterior nose.A 64-fold-higher delivery of dosage was predicted in the magnetized nose compared to the control case, which did not have a magnetic field.

View Article: PubMed Central - PubMed

Affiliation: School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA.

ABSTRACT

Background: Although direct nose-to-brain drug delivery has multiple advantages, its application is limited by the extremely low delivery efficiency (<1%) to the olfactory region where drugs can enter the brain. It is crucial to developing new methods that can deliver drug particles more effectively to the olfactory region.

Materials and methods: We introduced a delivery method that used magnetophoresis to improve olfactory delivery efficiency. The performance of the proposed method was assessed numerically in an image-based human nose model. Influences of the magnet layout, magnet strength, drug-release position, and particle diameter on the olfactory dosage were examined.

Results and discussion: Results showed that particle diameter was a critical factor in controlling the motion of nasally inhaled ferromagnetic drug particles. The optimal particle size was found to be approximately 15 μm for effective magnetophoretic guidance while avoiding loss of particles to the walls in the anterior nose. Olfactory delivery efficiency was shown to be sensitive to the position and strength of magnets and the release position of drug particles. The results of this study showed that clinically significant olfactory doses (up to 45%) were feasible using the optimal combination of magnet layout, selective drug release, and microsphere-carrier diameter. A 64-fold-higher delivery of dosage was predicted in the magnetized nose compared to the control case, which did not have a magnetic field. However, the sensitivity of olfactory dosage to operating conditions and the unstable nature of magnetophoresis make controlled guidance of nasally inhaled aerosols still highly challenging.

No MeSH data available.


Airflow (A) and particle trajectories in the 2-D nose without magnets (B) and with magnets (C).Note: Darker color in (C) represents a stronger magnetic field.
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f4-ijn-10-1211: Airflow (A) and particle trajectories in the 2-D nose without magnets (B) and with magnets (C).Note: Darker color in (C) represents a stronger magnetic field.

Mentions: The performance of the magnetophoretic guidance was further assessed in an idealized 2-D nose model. The airflow field within the nose is shown in Figure 4A. Only a small portion of the inhaled airflow is conveyed to the upper nasal cavity, indicating a low probability of particle transport to this region. From Figure 4A and B, streamlines that initiate from the nostril tip travel toward the upper nasal passage and those from the nostril base travel toward the inferior nasal passage. As a result, particles that are released from the nostril tip will be more likely to travel to the olfactory vicinity.


Improving intranasal delivery of neurological nanomedicine to the olfactory region using magnetophoretic guidance of microsphere carriers.

Xi J, Zhang Z, Si XA - Int J Nanomedicine (2015)

Airflow (A) and particle trajectories in the 2-D nose without magnets (B) and with magnets (C).Note: Darker color in (C) represents a stronger magnetic field.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4334328&req=5

f4-ijn-10-1211: Airflow (A) and particle trajectories in the 2-D nose without magnets (B) and with magnets (C).Note: Darker color in (C) represents a stronger magnetic field.
Mentions: The performance of the magnetophoretic guidance was further assessed in an idealized 2-D nose model. The airflow field within the nose is shown in Figure 4A. Only a small portion of the inhaled airflow is conveyed to the upper nasal cavity, indicating a low probability of particle transport to this region. From Figure 4A and B, streamlines that initiate from the nostril tip travel toward the upper nasal passage and those from the nostril base travel toward the inferior nasal passage. As a result, particles that are released from the nostril tip will be more likely to travel to the olfactory vicinity.

Bottom Line: It is crucial to developing new methods that can deliver drug particles more effectively to the olfactory region.The optimal particle size was found to be approximately 15 μm for effective magnetophoretic guidance while avoiding loss of particles to the walls in the anterior nose.A 64-fold-higher delivery of dosage was predicted in the magnetized nose compared to the control case, which did not have a magnetic field.

View Article: PubMed Central - PubMed

Affiliation: School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA.

ABSTRACT

Background: Although direct nose-to-brain drug delivery has multiple advantages, its application is limited by the extremely low delivery efficiency (<1%) to the olfactory region where drugs can enter the brain. It is crucial to developing new methods that can deliver drug particles more effectively to the olfactory region.

Materials and methods: We introduced a delivery method that used magnetophoresis to improve olfactory delivery efficiency. The performance of the proposed method was assessed numerically in an image-based human nose model. Influences of the magnet layout, magnet strength, drug-release position, and particle diameter on the olfactory dosage were examined.

Results and discussion: Results showed that particle diameter was a critical factor in controlling the motion of nasally inhaled ferromagnetic drug particles. The optimal particle size was found to be approximately 15 μm for effective magnetophoretic guidance while avoiding loss of particles to the walls in the anterior nose. Olfactory delivery efficiency was shown to be sensitive to the position and strength of magnets and the release position of drug particles. The results of this study showed that clinically significant olfactory doses (up to 45%) were feasible using the optimal combination of magnet layout, selective drug release, and microsphere-carrier diameter. A 64-fold-higher delivery of dosage was predicted in the magnetized nose compared to the control case, which did not have a magnetic field. However, the sensitivity of olfactory dosage to operating conditions and the unstable nature of magnetophoresis make controlled guidance of nasally inhaled aerosols still highly challenging.

No MeSH data available.