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Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD.

Gumus A, Altintas N, Cinarka H, Kirbas A, Hazıroglu M, Karatas M, Sahin U - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: We found that fibrinogen (P<0.001), CRP (P<0.001), and suPAR (P<0.001) were significantly higher in patients with AE-COPD than in healthy controls.Fibrinogen (P<0.001), CRP (P=0.001), and suPAR (P<0.001) were significantly decreased by the seventh day of treatment.However, the area under receiver operator characteristic curve showed that suPAR is superior to CRP and fibrinogen in distinguishing AE-COPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

ABSTRACT

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition, and progresses with acute exacerbations. (AE). During AE, levels of acute phase reactants such as C-reactive protein (CRP) and inflammatory cells in the circulation increase. Soluble urokinase-type plasminogen activator receptor (suPAR) levels increase in acute viral and bacterial infections and in diseases involving chronic inflammation. The purpose of this study was to investigate the effectiveness of suPAR in predicting diagnosis of AE of COPD (AE-COPD) and response to treatment.

Methods: The study population consisted of 43 patients diagnosed with AE-COPD and 30 healthy controls. suPAR, CRP, and fibrinogen levels were measured on the first day of hospitalization and on the seventh day of treatment.

Results: We found that fibrinogen (P<0.001), CRP (P<0.001), and suPAR (P<0.001) were significantly higher in patients with AE-COPD than in healthy controls. Fibrinogen (P<0.001), CRP (P=0.001), and suPAR (P<0.001) were significantly decreased by the seventh day of treatment. However, the area under receiver operator characteristic curve showed that suPAR is superior to CRP and fibrinogen in distinguishing AE-COPD. There was a correlation between fibrinogen, CRP, and suPAR. However, only fibrinogen was a powerful predictor of suPAR in multiple linear regression. In multiple logistic regression, only suPAR and fibrinogen were strong predictors of AE-COPD (P=0.002 and P=0.014, respectively). Serum suPAR was negatively correlated with forced expiratory volume in 1 second (r=-478, P=0.001).

Conclusion: suPAR is a marker of acute inflammation. It is well correlated with such inflammation markers as CRP and fibrinogen. suPAR can be used as a predictor of AE-COPD and in monitoring response to treatment.

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Related in: MedlinePlus

Serum soluble urokinase-type plasminogen activator receptor (suPAR) in healthy controls and in patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) on the first and seventh days.Notes: Data are expressed as boxplots, in which the horizontal lines illustrate the 25th, 50th, and 75th percentiles of the values of suPAR. The vertical lines represent the 5th and 95th percentiles.
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f1-copd-10-357: Serum soluble urokinase-type plasminogen activator receptor (suPAR) in healthy controls and in patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) on the first and seventh days.Notes: Data are expressed as boxplots, in which the horizontal lines illustrate the 25th, 50th, and 75th percentiles of the values of suPAR. The vertical lines represent the 5th and 95th percentiles.

Mentions: Median plasma suPAR in patients with AE-COPD (4.84±1.90 ng/mL) was significantly higher than in healthy controls (2.36±0.89 ng/mL; P<0.001) (Figure 1). Serum suPAR levels measured on the first and seventh days were compared to evaluate the response to treatment in patients with AE-COPD. A significant decrease in median suPAR level was observed after treatment, from 4.84±1.90 ng/mL to 3.38±1.34 ng/mL (P<0.001) as shown in Figure 2.


Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD.

Gumus A, Altintas N, Cinarka H, Kirbas A, Hazıroglu M, Karatas M, Sahin U - Int J Chron Obstruct Pulmon Dis (2015)

Serum soluble urokinase-type plasminogen activator receptor (suPAR) in healthy controls and in patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) on the first and seventh days.Notes: Data are expressed as boxplots, in which the horizontal lines illustrate the 25th, 50th, and 75th percentiles of the values of suPAR. The vertical lines represent the 5th and 95th percentiles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4334296&req=5

f1-copd-10-357: Serum soluble urokinase-type plasminogen activator receptor (suPAR) in healthy controls and in patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) on the first and seventh days.Notes: Data are expressed as boxplots, in which the horizontal lines illustrate the 25th, 50th, and 75th percentiles of the values of suPAR. The vertical lines represent the 5th and 95th percentiles.
Mentions: Median plasma suPAR in patients with AE-COPD (4.84±1.90 ng/mL) was significantly higher than in healthy controls (2.36±0.89 ng/mL; P<0.001) (Figure 1). Serum suPAR levels measured on the first and seventh days were compared to evaluate the response to treatment in patients with AE-COPD. A significant decrease in median suPAR level was observed after treatment, from 4.84±1.90 ng/mL to 3.38±1.34 ng/mL (P<0.001) as shown in Figure 2.

Bottom Line: We found that fibrinogen (P<0.001), CRP (P<0.001), and suPAR (P<0.001) were significantly higher in patients with AE-COPD than in healthy controls.Fibrinogen (P<0.001), CRP (P=0.001), and suPAR (P<0.001) were significantly decreased by the seventh day of treatment.However, the area under receiver operator characteristic curve showed that suPAR is superior to CRP and fibrinogen in distinguishing AE-COPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

ABSTRACT

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition, and progresses with acute exacerbations. (AE). During AE, levels of acute phase reactants such as C-reactive protein (CRP) and inflammatory cells in the circulation increase. Soluble urokinase-type plasminogen activator receptor (suPAR) levels increase in acute viral and bacterial infections and in diseases involving chronic inflammation. The purpose of this study was to investigate the effectiveness of suPAR in predicting diagnosis of AE of COPD (AE-COPD) and response to treatment.

Methods: The study population consisted of 43 patients diagnosed with AE-COPD and 30 healthy controls. suPAR, CRP, and fibrinogen levels were measured on the first day of hospitalization and on the seventh day of treatment.

Results: We found that fibrinogen (P<0.001), CRP (P<0.001), and suPAR (P<0.001) were significantly higher in patients with AE-COPD than in healthy controls. Fibrinogen (P<0.001), CRP (P=0.001), and suPAR (P<0.001) were significantly decreased by the seventh day of treatment. However, the area under receiver operator characteristic curve showed that suPAR is superior to CRP and fibrinogen in distinguishing AE-COPD. There was a correlation between fibrinogen, CRP, and suPAR. However, only fibrinogen was a powerful predictor of suPAR in multiple linear regression. In multiple logistic regression, only suPAR and fibrinogen were strong predictors of AE-COPD (P=0.002 and P=0.014, respectively). Serum suPAR was negatively correlated with forced expiratory volume in 1 second (r=-478, P=0.001).

Conclusion: suPAR is a marker of acute inflammation. It is well correlated with such inflammation markers as CRP and fibrinogen. suPAR can be used as a predictor of AE-COPD and in monitoring response to treatment.

Show MeSH
Related in: MedlinePlus