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Associations of polymorphisms of LOXL1 gene with primary open-angle glaucoma: a meta-analysis based on 5,293 subjects.

Wu M, Zhu XY, Ye J - Mol. Vis. (2015)

Bottom Line: We included 13 literatures including 5,293 subjects for the present study.In the Caucasian population, we also found that individuals carrying the C allele of rs2165241 have an increased risk for POAG compared to those subjects carrying the T allele (OR=1.42, 95% CI: 1.19~1.69, p=0.0001).In addition, we found that the rs1048661 polymorphism was associated with POAG in the Asian population (OR=1.17, 95% CI: 1.02~1.35, p=0.03), and rs3825942 was associated with POAG in the Caucasian population (OR=2.69, 95% CI: 1.61~4.47, p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

ABSTRACT

Objective: Previous studies indicated that the relationship between lysyl oxidase-like 1 (LOXL1) gene polymorphisms and primary open-angle glaucoma (POAG) remains inconsistent. In the present study, we aimed to perform a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk.

Methods: Literatures were electronically searched in the PubMed, EMBASE, CNKI, Wanfang, and VIP databases. The published literatures, which are case-control or cohort studies on the relationship between the polymorphisms (rs1048661, rs3825942, rs2165241) of the LOXL1 gene and POAG, were documented.

Results: We included 13 literatures including 5,293 subjects for the present study. A meta-analysis showed that the risk of POAG in individuals carrying the C allele of rs2165241 was 1.26 times higher compared with those carrying the T allele (odds ratio (OR)=1.26, 95% confidence interval (CI): 1.09~1.46) in the total population. In the Caucasian population, we also found that individuals carrying the C allele of rs2165241 have an increased risk for POAG compared to those subjects carrying the T allele (OR=1.42, 95% CI: 1.19~1.69, p=0.0001). In addition, we found that the rs1048661 polymorphism was associated with POAG in the Asian population (OR=1.17, 95% CI: 1.02~1.35, p=0.03), and rs3825942 was associated with POAG in the Caucasian population (OR=2.69, 95% CI: 1.61~4.47, p<0.001).

Conclusions: The polymorphisms of the LOXL1 gene were associated with the susceptibility of POAG.

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Related in: MedlinePlus

Begg’s funnel plot to test for a publication bias. Each circle denotes an independent study for the indicated association. Log [OR], natural logarithm of OR. Horizontal line stands for mean effect size. A: rs2165241; B: rs1048661; C: rs3825942.
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f8: Begg’s funnel plot to test for a publication bias. Each circle denotes an independent study for the indicated association. Log [OR], natural logarithm of OR. Horizontal line stands for mean effect size. A: rs2165241; B: rs1048661; C: rs3825942.

Mentions: We analyzed the publication bias using Revman 5.2 software; the funnel plot shows the points as evenly distributed and symmetric, and most of the points are within the 95% CI. This indicates no publication bias, and the result of the study is credible (Figure 8).


Associations of polymorphisms of LOXL1 gene with primary open-angle glaucoma: a meta-analysis based on 5,293 subjects.

Wu M, Zhu XY, Ye J - Mol. Vis. (2015)

Begg’s funnel plot to test for a publication bias. Each circle denotes an independent study for the indicated association. Log [OR], natural logarithm of OR. Horizontal line stands for mean effect size. A: rs2165241; B: rs1048661; C: rs3825942.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4333729&req=5

f8: Begg’s funnel plot to test for a publication bias. Each circle denotes an independent study for the indicated association. Log [OR], natural logarithm of OR. Horizontal line stands for mean effect size. A: rs2165241; B: rs1048661; C: rs3825942.
Mentions: We analyzed the publication bias using Revman 5.2 software; the funnel plot shows the points as evenly distributed and symmetric, and most of the points are within the 95% CI. This indicates no publication bias, and the result of the study is credible (Figure 8).

Bottom Line: We included 13 literatures including 5,293 subjects for the present study.In the Caucasian population, we also found that individuals carrying the C allele of rs2165241 have an increased risk for POAG compared to those subjects carrying the T allele (OR=1.42, 95% CI: 1.19~1.69, p=0.0001).In addition, we found that the rs1048661 polymorphism was associated with POAG in the Asian population (OR=1.17, 95% CI: 1.02~1.35, p=0.03), and rs3825942 was associated with POAG in the Caucasian population (OR=2.69, 95% CI: 1.61~4.47, p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

ABSTRACT

Objective: Previous studies indicated that the relationship between lysyl oxidase-like 1 (LOXL1) gene polymorphisms and primary open-angle glaucoma (POAG) remains inconsistent. In the present study, we aimed to perform a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk.

Methods: Literatures were electronically searched in the PubMed, EMBASE, CNKI, Wanfang, and VIP databases. The published literatures, which are case-control or cohort studies on the relationship between the polymorphisms (rs1048661, rs3825942, rs2165241) of the LOXL1 gene and POAG, were documented.

Results: We included 13 literatures including 5,293 subjects for the present study. A meta-analysis showed that the risk of POAG in individuals carrying the C allele of rs2165241 was 1.26 times higher compared with those carrying the T allele (odds ratio (OR)=1.26, 95% confidence interval (CI): 1.09~1.46) in the total population. In the Caucasian population, we also found that individuals carrying the C allele of rs2165241 have an increased risk for POAG compared to those subjects carrying the T allele (OR=1.42, 95% CI: 1.19~1.69, p=0.0001). In addition, we found that the rs1048661 polymorphism was associated with POAG in the Asian population (OR=1.17, 95% CI: 1.02~1.35, p=0.03), and rs3825942 was associated with POAG in the Caucasian population (OR=2.69, 95% CI: 1.61~4.47, p<0.001).

Conclusions: The polymorphisms of the LOXL1 gene were associated with the susceptibility of POAG.

Show MeSH
Related in: MedlinePlus