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Stem cell therapy: A novel treatment approach for oral mucosal lesions.

Suma GN, Arora MP, Lakhanpal M - J Pharm Bioallied Sci (2015 Jan-Mar)

Bottom Line: The research in this field is growing at an exponential rate.At present, the adult mesenchymal stem cells are being used in the head and neck region for orofacial regeneration (including enamel, dentin, pulp and alveolar bone) in lieu of their proliferative and regenerative properties, their use in the treatment of oral mucosal lesions is still in budding stages.Moreover, there is scanty literature available regarding role of stem cell therapy in the treatment of commonly seen oral mucosal lesions like oral submucous fibrosis, oral lichen planus, oral ulcers and oral mucositis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, ITS CDSR, Dental College and Hospital, Muradnagar, Ghaziabad, Uttar Pradesh, India.

ABSTRACT
Stem cells have enormous potential to alleviate sufferings of many diseases that currently have no effective therapy. The research in this field is growing at an exponential rate. Stem cells are master cells that have specialized capability for self-renewal, potency and capability to differentiate to many cell types. At present, the adult mesenchymal stem cells are being used in the head and neck region for orofacial regeneration (including enamel, dentin, pulp and alveolar bone) in lieu of their proliferative and regenerative properties, their use in the treatment of oral mucosal lesions is still in budding stages. Moreover, there is scanty literature available regarding role of stem cell therapy in the treatment of commonly seen oral mucosal lesions like oral submucous fibrosis, oral lichen planus, oral ulcers and oral mucositis. The present review will focus on the current knowledge about the role of stem cell therapies in oral mucosal lesions and could facilitate new advancements in this area (articles were obtained from electronic media like PubMed, EBSCO, Cochrane and Medline etc., from year 2000 to 2014 to review the role of stem cell therapy in oral mucosal lesions).

No MeSH data available.


Related in: MedlinePlus

Role of stem cells in cancer therapy
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Related In: Results  -  Collection

License
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Figure 6: Role of stem cells in cancer therapy

Mentions: Another important aspect of their use in cancer therapy is the use as delivery vehicles.[32] Systematic delivery of drug or gene therapy has promising future but is currently limited by various factors such as immune detection, nonspecific accumulation in normal tissues and poor permeation. Stem cells can act as cell-based carriers that may target the desired site. The recent concept of use of stem cells as delivery vehicles came from the fact that the tumors send out chemo-attractants such as VEGF to recruit MSC to form the supporting stroma of the tumor.[33] However, further work is required to understand the role of stem cells in cancer therapies, with the eventual goal of eliminating the residual disease and recurrence [Figure 6].


Stem cell therapy: A novel treatment approach for oral mucosal lesions.

Suma GN, Arora MP, Lakhanpal M - J Pharm Bioallied Sci (2015 Jan-Mar)

Role of stem cells in cancer therapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4333622&req=5

Figure 6: Role of stem cells in cancer therapy
Mentions: Another important aspect of their use in cancer therapy is the use as delivery vehicles.[32] Systematic delivery of drug or gene therapy has promising future but is currently limited by various factors such as immune detection, nonspecific accumulation in normal tissues and poor permeation. Stem cells can act as cell-based carriers that may target the desired site. The recent concept of use of stem cells as delivery vehicles came from the fact that the tumors send out chemo-attractants such as VEGF to recruit MSC to form the supporting stroma of the tumor.[33] However, further work is required to understand the role of stem cells in cancer therapies, with the eventual goal of eliminating the residual disease and recurrence [Figure 6].

Bottom Line: The research in this field is growing at an exponential rate.At present, the adult mesenchymal stem cells are being used in the head and neck region for orofacial regeneration (including enamel, dentin, pulp and alveolar bone) in lieu of their proliferative and regenerative properties, their use in the treatment of oral mucosal lesions is still in budding stages.Moreover, there is scanty literature available regarding role of stem cell therapy in the treatment of commonly seen oral mucosal lesions like oral submucous fibrosis, oral lichen planus, oral ulcers and oral mucositis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, ITS CDSR, Dental College and Hospital, Muradnagar, Ghaziabad, Uttar Pradesh, India.

ABSTRACT
Stem cells have enormous potential to alleviate sufferings of many diseases that currently have no effective therapy. The research in this field is growing at an exponential rate. Stem cells are master cells that have specialized capability for self-renewal, potency and capability to differentiate to many cell types. At present, the adult mesenchymal stem cells are being used in the head and neck region for orofacial regeneration (including enamel, dentin, pulp and alveolar bone) in lieu of their proliferative and regenerative properties, their use in the treatment of oral mucosal lesions is still in budding stages. Moreover, there is scanty literature available regarding role of stem cell therapy in the treatment of commonly seen oral mucosal lesions like oral submucous fibrosis, oral lichen planus, oral ulcers and oral mucositis. The present review will focus on the current knowledge about the role of stem cell therapies in oral mucosal lesions and could facilitate new advancements in this area (articles were obtained from electronic media like PubMed, EBSCO, Cochrane and Medline etc., from year 2000 to 2014 to review the role of stem cell therapy in oral mucosal lesions).

No MeSH data available.


Related in: MedlinePlus