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Anti-Candida activity of Quercus infectoria gall extracts against Candida species.

Baharuddin NS, Abdullah H, Abdul Wahab WN - J Pharm Bioallied Sci (2015 Jan-Mar)

Bottom Line: Potential phytochemical group in the crude extracts was screened by phytochemical qualitative tests and subsequently subjected to the gas chromatography-mass spectrometry analysis.Both methanol and aqueous extracts displayed substantial anti-Candida activity and pyrogallol was the major component of both crude extracts.Data from current study suggested that Q. infectoria gall extracts are a potential source to be developed as anti-candidiasis.

View Article: PubMed Central - PubMed

Affiliation: Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan.

ABSTRACT

Background: Galls of Quercus infectoria have been traditionally used to treat common ailments, including yeast infections caused by Candida species.

Objective: This study aimed to evaluate the in vitro anti-Candida activity of Q. infectoria gall extracts against selected Candida species.

Materials and methods: Methanol and aqueous extracts of Q. infectoria galls were tested for anti-Candida activity against Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis and Candida tropicalis. The minimum inhibitory concentrations were determined using the two-fold serial dilution technique of concentrations ranging from 16 mg/ml to 0.03 mg/ml. After 24 h, the minimum fungicidal concentrations were determined by subculturing the wells, which showed no turbidity on the agar plate. Potential phytochemical group in the crude extracts was screened by phytochemical qualitative tests and subsequently subjected to the gas chromatography-mass spectrometry analysis.

Results: Both methanol and aqueous extracts displayed substantial anti-Candida activity and pyrogallol was the major component of both crude extracts.

Conclusions: Data from current study suggested that Q. infectoria gall extracts are a potential source to be developed as anti-candidiasis.

No MeSH data available.


Related in: MedlinePlus

Gall of Quercus infectoria olivier
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Figure 1: Gall of Quercus infectoria olivier

Mentions: Quercus infectoria olivier galls [Figure 1] were purchased from the local herbal shop in Kota Bharu, Kelantan and identified based on their physical appearances which were globular in shape, 0.8 cm to 2.5 cm in diameter, green-yellow in color, odor is slight, strongly pungent taste and tuberculated surface.[12] The galls were washed with distilled water, left dry at room temperature before they were crushed and ground prior to the extraction.


Anti-Candida activity of Quercus infectoria gall extracts against Candida species.

Baharuddin NS, Abdullah H, Abdul Wahab WN - J Pharm Bioallied Sci (2015 Jan-Mar)

Gall of Quercus infectoria olivier
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4333621&req=5

Figure 1: Gall of Quercus infectoria olivier
Mentions: Quercus infectoria olivier galls [Figure 1] were purchased from the local herbal shop in Kota Bharu, Kelantan and identified based on their physical appearances which were globular in shape, 0.8 cm to 2.5 cm in diameter, green-yellow in color, odor is slight, strongly pungent taste and tuberculated surface.[12] The galls were washed with distilled water, left dry at room temperature before they were crushed and ground prior to the extraction.

Bottom Line: Potential phytochemical group in the crude extracts was screened by phytochemical qualitative tests and subsequently subjected to the gas chromatography-mass spectrometry analysis.Both methanol and aqueous extracts displayed substantial anti-Candida activity and pyrogallol was the major component of both crude extracts.Data from current study suggested that Q. infectoria gall extracts are a potential source to be developed as anti-candidiasis.

View Article: PubMed Central - PubMed

Affiliation: Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan.

ABSTRACT

Background: Galls of Quercus infectoria have been traditionally used to treat common ailments, including yeast infections caused by Candida species.

Objective: This study aimed to evaluate the in vitro anti-Candida activity of Q. infectoria gall extracts against selected Candida species.

Materials and methods: Methanol and aqueous extracts of Q. infectoria galls were tested for anti-Candida activity against Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis and Candida tropicalis. The minimum inhibitory concentrations were determined using the two-fold serial dilution technique of concentrations ranging from 16 mg/ml to 0.03 mg/ml. After 24 h, the minimum fungicidal concentrations were determined by subculturing the wells, which showed no turbidity on the agar plate. Potential phytochemical group in the crude extracts was screened by phytochemical qualitative tests and subsequently subjected to the gas chromatography-mass spectrometry analysis.

Results: Both methanol and aqueous extracts displayed substantial anti-Candida activity and pyrogallol was the major component of both crude extracts.

Conclusions: Data from current study suggested that Q. infectoria gall extracts are a potential source to be developed as anti-candidiasis.

No MeSH data available.


Related in: MedlinePlus