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Disturbed diastolic left ventricular inflow vortex ring formation in patients with corrected atrioventricular septal defect: quantitative three-dimensional vortex core analysis from 4DFlow MRI

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Vortex formation in the left ventricle (LV) is suggested to contribute to efficient blood pumping and altered vortex formation is associated with diastolic dysfunction... We aimed to analyze vortex ring formation in AVSD-corrected patients compared to healthy controls and to evaluate association with inflow angle. 23 patients (age 20±8 years) and 23 healthy controls (age 19±8 years) were included... The circularity index (CI) was calculated to quantify the shape of the vortex ring... Measured parameters of controls and patients were compared using chi-square tests and non-parametric t-tests... The larger value in R-coordinate observed in patients indicates a more lateral position of the vortex core center in patients during E-peak and A-peak... In patients a less circular shape of the vortex core was observed compared to controls... In patients the correlation between vortex orientation and inflow angle was r=0.5 (p=0.06) at E-peak and r= 0.7 (p=0.01) at A-peak... Presence and formation of vortex ring core is aberrant in patients with corrected AVSD compared to healthy controls... Different position and circularity of the vortex cores are possibly due to abnormalities in the left atrioventricular valve... Altered vortex orientation is correlated with patients' lateral inflow... Future studies are required to investigate the effect of absence or altered vortex ring formation on energy loss.

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Vortex ring core in a control and a patient during E-peak. In the patient a more tilted (orientation 37 degrees) and more lateral positioned (R = 0.39) vortex was observed. RA = right atrium, RV = right ventricle, LA = left atrium, LV = left ventricle.
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Figure 1: Vortex ring core in a control and a patient during E-peak. In the patient a more tilted (orientation 37 degrees) and more lateral positioned (R = 0.39) vortex was observed. RA = right atrium, RV = right ventricle, LA = left atrium, LV = left ventricle.


Disturbed diastolic left ventricular inflow vortex ring formation in patients with corrected atrioventricular septal defect: quantitative three-dimensional vortex core analysis from 4DFlow MRI
Vortex ring core in a control and a patient during E-peak. In the patient a more tilted (orientation 37 degrees) and more lateral positioned (R = 0.39) vortex was observed. RA = right atrium, RV = right ventricle, LA = left atrium, LV = left ventricle.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328975&req=5

Figure 1: Vortex ring core in a control and a patient during E-peak. In the patient a more tilted (orientation 37 degrees) and more lateral positioned (R = 0.39) vortex was observed. RA = right atrium, RV = right ventricle, LA = left atrium, LV = left ventricle.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Vortex formation in the left ventricle (LV) is suggested to contribute to efficient blood pumping and altered vortex formation is associated with diastolic dysfunction... We aimed to analyze vortex ring formation in AVSD-corrected patients compared to healthy controls and to evaluate association with inflow angle. 23 patients (age 20±8 years) and 23 healthy controls (age 19±8 years) were included... The circularity index (CI) was calculated to quantify the shape of the vortex ring... Measured parameters of controls and patients were compared using chi-square tests and non-parametric t-tests... The larger value in R-coordinate observed in patients indicates a more lateral position of the vortex core center in patients during E-peak and A-peak... In patients a less circular shape of the vortex core was observed compared to controls... In patients the correlation between vortex orientation and inflow angle was r=0.5 (p=0.06) at E-peak and r= 0.7 (p=0.01) at A-peak... Presence and formation of vortex ring core is aberrant in patients with corrected AVSD compared to healthy controls... Different position and circularity of the vortex cores are possibly due to abnormalities in the left atrioventricular valve... Altered vortex orientation is correlated with patients' lateral inflow... Future studies are required to investigate the effect of absence or altered vortex ring formation on energy loss.

No MeSH data available.