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Respiratory pulsations affect fontan connection power loss: using real time velocity mapping to improve the accuracy of computational simulations

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Total cavopulmonary connection (TCPC) hemodynamics has been hypothesized to be associated with long-term complications in single ventricle heart defect patients... TCPC power loss was quantified and qualitative flow structure within the TCPC was compared between FB and BH conditions... The average vessel flow rates at the IVC and SVC were found to be 3.3±0.9L/min and 1.9±1.1L/min at FB compared to 3.1±1.1 L/min and 1.4±1.1 L/min during BH condition... Pulsatility indices were on average 211%±124% (IVC) and 224%±95% (SVC) during FB, compared to 102%±60% (IVC) and 176%±90% (SVC) during BH... Higher power loss across the connection was also observed in the FB condition in Patient 1 (Table 1)... Despite minimal impact on net flows, respiration has considerable impact on TCPC hemodynamics... Vessel flow waveforms acquired with FB condition have higher flow pulsatility... This translates into qualitative differences in flow structure within the connection, and increases in TCPC power loss... The importance of respiratory effects is highlighted, and potential error of calculation of energy dissipation by using BH acquisitions is demonstrated.

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(a) Resting flow waveforms of IVC and SVC of Patient 1 at FB and BH conditions for 1 respiratory cycle (4 cardiac cycles for BH), along with the respiratory cycle determined by tracking the chest wall motion from the IVC MRI images; (b) Particle tracking results within the TCPC under simulated FB and BH conditions for Patient 1 at various time points. Particles were seeded at the IVC and SVC for 1 respiratory cycle, and were allowed to advect for additional 5 respiratory cycles.
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Figure 1: (a) Resting flow waveforms of IVC and SVC of Patient 1 at FB and BH conditions for 1 respiratory cycle (4 cardiac cycles for BH), along with the respiratory cycle determined by tracking the chest wall motion from the IVC MRI images; (b) Particle tracking results within the TCPC under simulated FB and BH conditions for Patient 1 at various time points. Particles were seeded at the IVC and SVC for 1 respiratory cycle, and were allowed to advect for additional 5 respiratory cycles.

Mentions: The average vessel flow rates at the IVC and SVC were found to be 3.3±0.9L/min and 1.9±1.1L/min at FB compared to 3.1±1.1 L/min and 1.4±1.1 L/min during BH condition. Pulsatility indices were on average 211%±124% (IVC) and 224%±95% (SVC) during FB, compared to 102%±60% (IVC) and 176%±90% (SVC) during BH. Taking CFD results of Patient 1 as example, inspiration led to higher anterograde flow compared to breath-held condition, and expiration causes retrograde flow; together, they result in differences in flow structure between FB and BH conditions. From the particle tracking results, more particles remain within the TCPC volume after 2 respiratory cycles in the FB condition compared to BH (Figure 1), highlighting the longer particle washout time in the FB condition. Higher power loss across the connection was also observed in the FB condition in Patient 1 (Table 1).


Respiratory pulsations affect fontan connection power loss: using real time velocity mapping to improve the accuracy of computational simulations
(a) Resting flow waveforms of IVC and SVC of Patient 1 at FB and BH conditions for 1 respiratory cycle (4 cardiac cycles for BH), along with the respiratory cycle determined by tracking the chest wall motion from the IVC MRI images; (b) Particle tracking results within the TCPC under simulated FB and BH conditions for Patient 1 at various time points. Particles were seeded at the IVC and SVC for 1 respiratory cycle, and were allowed to advect for additional 5 respiratory cycles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328973&req=5

Figure 1: (a) Resting flow waveforms of IVC and SVC of Patient 1 at FB and BH conditions for 1 respiratory cycle (4 cardiac cycles for BH), along with the respiratory cycle determined by tracking the chest wall motion from the IVC MRI images; (b) Particle tracking results within the TCPC under simulated FB and BH conditions for Patient 1 at various time points. Particles were seeded at the IVC and SVC for 1 respiratory cycle, and were allowed to advect for additional 5 respiratory cycles.
Mentions: The average vessel flow rates at the IVC and SVC were found to be 3.3±0.9L/min and 1.9±1.1L/min at FB compared to 3.1±1.1 L/min and 1.4±1.1 L/min during BH condition. Pulsatility indices were on average 211%±124% (IVC) and 224%±95% (SVC) during FB, compared to 102%±60% (IVC) and 176%±90% (SVC) during BH. Taking CFD results of Patient 1 as example, inspiration led to higher anterograde flow compared to breath-held condition, and expiration causes retrograde flow; together, they result in differences in flow structure between FB and BH conditions. From the particle tracking results, more particles remain within the TCPC volume after 2 respiratory cycles in the FB condition compared to BH (Figure 1), highlighting the longer particle washout time in the FB condition. Higher power loss across the connection was also observed in the FB condition in Patient 1 (Table 1).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Total cavopulmonary connection (TCPC) hemodynamics has been hypothesized to be associated with long-term complications in single ventricle heart defect patients... TCPC power loss was quantified and qualitative flow structure within the TCPC was compared between FB and BH conditions... The average vessel flow rates at the IVC and SVC were found to be 3.3±0.9L/min and 1.9±1.1L/min at FB compared to 3.1±1.1 L/min and 1.4±1.1 L/min during BH condition... Pulsatility indices were on average 211%±124% (IVC) and 224%±95% (SVC) during FB, compared to 102%±60% (IVC) and 176%±90% (SVC) during BH... Higher power loss across the connection was also observed in the FB condition in Patient 1 (Table 1)... Despite minimal impact on net flows, respiration has considerable impact on TCPC hemodynamics... Vessel flow waveforms acquired with FB condition have higher flow pulsatility... This translates into qualitative differences in flow structure within the connection, and increases in TCPC power loss... The importance of respiratory effects is highlighted, and potential error of calculation of energy dissipation by using BH acquisitions is demonstrated.

No MeSH data available.


Related in: MedlinePlus