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Free-breathing myocardial T2* mapping using GRE-EPI and automatic non-rigid motion correction

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Myocardial T2* mapping is a widely used method to detect and quantify cardiac iron overload in transfusion-dependent anemia patients (1, 2)... In this work, we present a new free-breathing technique to accurately quantify myocardial T2* by acquiring multiple, single heartbeat images insensitive to respiratory motion artifact, and applying automatic non-rigid motion correction (moco GRE-EPI) to register images prior to T2* map estimation... Both moco GRE-EPI during free-breathing and BH Seg-mGRE during breath-hold were acquired in a single mid-short axis plane... T2* was measured in the interventricular septum and liver... Conventional BH Seg-GRE failed in 24 out of 72 patients due to the inability to breath-hold while the new moco GRE-EPI technique failed in only 6 patients due to the severe respiratory motion or imperfect fat suppression (Figure 1, Panels A-C)... Comparisons between T2* measured in the intra-ventricular septum and the liver from the two techniques in 45 patients with adequate images using both techniques (Figure 1, panels D and E) demonstrated strong correlations (r = 0.77 and 0.97) and no significant differences (p = 0.78 and 0.24)... We have described a technique for T2* mapping using moco GRE-EPI that enables accurate myocardial T2* measurements and is insensitive to respiratory motion... It could be especially beneficial for patients who are unable to breath-hold.

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(A) motion corrected averaged T2*-weighted images at TE = 1.9, 7 and 15 ms from the moco GRE-EPI sequence. (B) One example of good T2* map quality for BH seg-mGRE and moco GRE-EPI in a patient able to breath hold. (C) In patients unable to breath hold, free-breathing moco GRE-EPI improves T2* map quality. (D, E) Comparisons between the mean T2* measured in the intraventricular septum and the liver from the two techniques demonstrated strong correlations and no significant differences.
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Figure 1: (A) motion corrected averaged T2*-weighted images at TE = 1.9, 7 and 15 ms from the moco GRE-EPI sequence. (B) One example of good T2* map quality for BH seg-mGRE and moco GRE-EPI in a patient able to breath hold. (C) In patients unable to breath hold, free-breathing moco GRE-EPI improves T2* map quality. (D, E) Comparisons between the mean T2* measured in the intraventricular septum and the liver from the two techniques demonstrated strong correlations and no significant differences.

Mentions: Conventional BH Seg-GRE failed in 24 out of 72 patients due to the inability to breath-hold while the new moco GRE-EPI technique failed in only 6 patients due to the severe respiratory motion or imperfect fat suppression (Figure 1, Panels A-C). Comparisons between T2* measured in the intra-ventricular septum and the liver from the two techniques in 45 patients with adequate images using both techniques (Figure 1, panels D and E) demonstrated strong correlations (r = 0.77 and 0.97) and no significant differences (p = 0.78 and 0.24).


Free-breathing myocardial T2* mapping using GRE-EPI and automatic non-rigid motion correction
(A) motion corrected averaged T2*-weighted images at TE = 1.9, 7 and 15 ms from the moco GRE-EPI sequence. (B) One example of good T2* map quality for BH seg-mGRE and moco GRE-EPI in a patient able to breath hold. (C) In patients unable to breath hold, free-breathing moco GRE-EPI improves T2* map quality. (D, E) Comparisons between the mean T2* measured in the intraventricular septum and the liver from the two techniques demonstrated strong correlations and no significant differences.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328959&req=5

Figure 1: (A) motion corrected averaged T2*-weighted images at TE = 1.9, 7 and 15 ms from the moco GRE-EPI sequence. (B) One example of good T2* map quality for BH seg-mGRE and moco GRE-EPI in a patient able to breath hold. (C) In patients unable to breath hold, free-breathing moco GRE-EPI improves T2* map quality. (D, E) Comparisons between the mean T2* measured in the intraventricular septum and the liver from the two techniques demonstrated strong correlations and no significant differences.
Mentions: Conventional BH Seg-GRE failed in 24 out of 72 patients due to the inability to breath-hold while the new moco GRE-EPI technique failed in only 6 patients due to the severe respiratory motion or imperfect fat suppression (Figure 1, Panels A-C). Comparisons between T2* measured in the intra-ventricular septum and the liver from the two techniques in 45 patients with adequate images using both techniques (Figure 1, panels D and E) demonstrated strong correlations (r = 0.77 and 0.97) and no significant differences (p = 0.78 and 0.24).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Myocardial T2* mapping is a widely used method to detect and quantify cardiac iron overload in transfusion-dependent anemia patients (1, 2)... In this work, we present a new free-breathing technique to accurately quantify myocardial T2* by acquiring multiple, single heartbeat images insensitive to respiratory motion artifact, and applying automatic non-rigid motion correction (moco GRE-EPI) to register images prior to T2* map estimation... Both moco GRE-EPI during free-breathing and BH Seg-mGRE during breath-hold were acquired in a single mid-short axis plane... T2* was measured in the interventricular septum and liver... Conventional BH Seg-GRE failed in 24 out of 72 patients due to the inability to breath-hold while the new moco GRE-EPI technique failed in only 6 patients due to the severe respiratory motion or imperfect fat suppression (Figure 1, Panels A-C)... Comparisons between T2* measured in the intra-ventricular septum and the liver from the two techniques in 45 patients with adequate images using both techniques (Figure 1, panels D and E) demonstrated strong correlations (r = 0.77 and 0.97) and no significant differences (p = 0.78 and 0.24)... We have described a technique for T2* mapping using moco GRE-EPI that enables accurate myocardial T2* measurements and is insensitive to respiratory motion... It could be especially beneficial for patients who are unable to breath-hold.

No MeSH data available.


Related in: MedlinePlus