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Validation of high temporal resolution spiral phase velocity mapping of coronary artery blood flow against Doppler flow wire

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The temporal pattern of coronary artery flow velocity through the cardiac cycle provides important information about coronary haemodynamics... In this study, we perform an in vivo comparison of coronary blood flow velocities measured with breath-hold high temporal resolution spiral phase velocity mapping and Doppler flow wire measurements... Extraction of MR coronary artery blood flow velocity-time curves was performed using a custom MATLAB program which tracked the motion of the vessel over the cardiac cycle and corrected for the through-plane motion of the vessel using a region of adjacent tracked myocardium (LAD) or a region of surrounding epicardial fat (RCA) from a separately acquired fat-excitation acquisition... For each vessel, the mean through-plane motion-corrected MR velocities at all timepoints were plotted against the equivalent flow wire velocities... If necessary, the profiles were first time-shifted to take into account small differences in data triggering between the two techniques... The correlation between the two profiles was assessed using simple linear regression analysis... Figures 1 and 2 show example LAD and RCA studies... On average, the MR measured velocities were 66% less than the Flowire velocities (SD 9%, range: 50% - 78%)... The correlation between the MR and flow wire data, however, was high, with R values ranging from 0.6 - 0.95 in the 8 vessels studied (mean R = .80)... However, temporal flow profiles measured in the proximal coronary arteries using breath-hold interleaved spiral phase velocity mapping are highly similar to those measured with Doppler flow wire... We conclude that spiral phase velocity mapping of coronary artery blood flow has the potential to assess temporal flow patterns in the proximal coronary arteries.

No MeSH data available.


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Example early diastolic RCA (arrow) magnitude image and velocity map from a high temporal resolution spiral phase velocity mapping acquisition (a), together with the corresponding Doppler Flowire trace (b). A plot of MR and Flowire measured coronary blood flow velocities against time in the cardiac cycle is shown in (c), together with a plot of the Flowire velocities against the MR velocities.
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Figure 2: Example early diastolic RCA (arrow) magnitude image and velocity map from a high temporal resolution spiral phase velocity mapping acquisition (a), together with the corresponding Doppler Flowire trace (b). A plot of MR and Flowire measured coronary blood flow velocities against time in the cardiac cycle is shown in (c), together with a plot of the Flowire velocities against the MR velocities.

Mentions: Figures 1 and 2 show example LAD and RCA studies. On average, the MR measured velocities were 66% less than the Flowire velocities (SD 9%, range: 50% - 78%). The correlation between the MR and flow wire data, however, was high, with R2 values ranging from 0.6 - 0.95 in the 8 vessels studied (mean R2 = .80).


Validation of high temporal resolution spiral phase velocity mapping of coronary artery blood flow against Doppler flow wire
Example early diastolic RCA (arrow) magnitude image and velocity map from a high temporal resolution spiral phase velocity mapping acquisition (a), together with the corresponding Doppler Flowire trace (b). A plot of MR and Flowire measured coronary blood flow velocities against time in the cardiac cycle is shown in (c), together with a plot of the Flowire velocities against the MR velocities.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328957&req=5

Figure 2: Example early diastolic RCA (arrow) magnitude image and velocity map from a high temporal resolution spiral phase velocity mapping acquisition (a), together with the corresponding Doppler Flowire trace (b). A plot of MR and Flowire measured coronary blood flow velocities against time in the cardiac cycle is shown in (c), together with a plot of the Flowire velocities against the MR velocities.
Mentions: Figures 1 and 2 show example LAD and RCA studies. On average, the MR measured velocities were 66% less than the Flowire velocities (SD 9%, range: 50% - 78%). The correlation between the MR and flow wire data, however, was high, with R2 values ranging from 0.6 - 0.95 in the 8 vessels studied (mean R2 = .80).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The temporal pattern of coronary artery flow velocity through the cardiac cycle provides important information about coronary haemodynamics... In this study, we perform an in vivo comparison of coronary blood flow velocities measured with breath-hold high temporal resolution spiral phase velocity mapping and Doppler flow wire measurements... Extraction of MR coronary artery blood flow velocity-time curves was performed using a custom MATLAB program which tracked the motion of the vessel over the cardiac cycle and corrected for the through-plane motion of the vessel using a region of adjacent tracked myocardium (LAD) or a region of surrounding epicardial fat (RCA) from a separately acquired fat-excitation acquisition... For each vessel, the mean through-plane motion-corrected MR velocities at all timepoints were plotted against the equivalent flow wire velocities... If necessary, the profiles were first time-shifted to take into account small differences in data triggering between the two techniques... The correlation between the two profiles was assessed using simple linear regression analysis... Figures 1 and 2 show example LAD and RCA studies... On average, the MR measured velocities were 66% less than the Flowire velocities (SD 9%, range: 50% - 78%)... The correlation between the MR and flow wire data, however, was high, with R values ranging from 0.6 - 0.95 in the 8 vessels studied (mean R = .80)... However, temporal flow profiles measured in the proximal coronary arteries using breath-hold interleaved spiral phase velocity mapping are highly similar to those measured with Doppler flow wire... We conclude that spiral phase velocity mapping of coronary artery blood flow has the potential to assess temporal flow patterns in the proximal coronary arteries.

No MeSH data available.


Related in: MedlinePlus