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MR augmented cardiopulmonary exercise testing - a novel method of assessing cardiovascular function

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However, measuring peak VO2 alone neglects the different components of reduced exercise capacity: namely reduced cardiac output (CO) and oxygen extraction (ΔcO2)... A better approach would be to simultaneously measure VO2 and CO and then calculate ΔcO2... This could be achieved using MR augmented cardio-pulmonary exercise testing (MR-CPET) The aims of this study were to demonstrate: 1) MR-CPET is feasible and well tolerated, 2) peak VO2 in the MR scanner correlates with conventional peak VO2, and 3) variation in peak VO2 is related to both peak CO and peak oxygen extraction (ΔcO2) as calculated by the Fick equation. 17 healthy volunteers (21-55 years) underwent MR-CPET... Conventional CPET was also performed within 2 weeks of MR-CPET... Multiple linear regression analysis demonstrated that both peak CO and ΔcO2 were independent predictors of peak VO2 measured during MR-CPET (beta=0.73 and 0.38 respectively, p<0.0001) and conventional CPET (beta=0.78, 0.28 respectively, p<0.0001)... Representative VO2, CO and ΔcO2 are shown in figure 1... MR-CPET is feasible, well tolerated and demonstrates physiology not apparent with conventional CPET... In this study, we have shown that MR-CPET allows assessment of the differing contributions of CO and ΔcO2 to variation in peak VO2.

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Mentions: Peak VO2, peak VCO2 and VE showed strong correlation between conventional CPET and MR-CPET: VO2 peak (r=0.94, p<0.001); VCO2 (r=0.87, p<0.001); VE (r=0.88, p<0.001). Resting and peak values VO2, CO, HR, SV and ΔcO2 are shown in table 1. Multiple linear regression analysis demonstrated that both peak CO and ΔcO2 were independent predictors of peak VO2 measured during MR-CPET (beta=0.73 and 0.38 respectively, p<0.0001) and conventional CPET (beta=0.78, 0.28 respectively, p<0.0001). Representative VO2, CO and ΔcO2 are shown in figure 1.


MR augmented cardiopulmonary exercise testing - a novel method of assessing cardiovascular function
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328955&req=5

Mentions: Peak VO2, peak VCO2 and VE showed strong correlation between conventional CPET and MR-CPET: VO2 peak (r=0.94, p<0.001); VCO2 (r=0.87, p<0.001); VE (r=0.88, p<0.001). Resting and peak values VO2, CO, HR, SV and ΔcO2 are shown in table 1. Multiple linear regression analysis demonstrated that both peak CO and ΔcO2 were independent predictors of peak VO2 measured during MR-CPET (beta=0.73 and 0.38 respectively, p<0.0001) and conventional CPET (beta=0.78, 0.28 respectively, p<0.0001). Representative VO2, CO and ΔcO2 are shown in figure 1.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

However, measuring peak VO2 alone neglects the different components of reduced exercise capacity: namely reduced cardiac output (CO) and oxygen extraction (ΔcO2)... A better approach would be to simultaneously measure VO2 and CO and then calculate ΔcO2... This could be achieved using MR augmented cardio-pulmonary exercise testing (MR-CPET) The aims of this study were to demonstrate: 1) MR-CPET is feasible and well tolerated, 2) peak VO2 in the MR scanner correlates with conventional peak VO2, and 3) variation in peak VO2 is related to both peak CO and peak oxygen extraction (ΔcO2) as calculated by the Fick equation. 17 healthy volunteers (21-55 years) underwent MR-CPET... Conventional CPET was also performed within 2 weeks of MR-CPET... Multiple linear regression analysis demonstrated that both peak CO and ΔcO2 were independent predictors of peak VO2 measured during MR-CPET (beta=0.73 and 0.38 respectively, p<0.0001) and conventional CPET (beta=0.78, 0.28 respectively, p<0.0001)... Representative VO2, CO and ΔcO2 are shown in figure 1... MR-CPET is feasible, well tolerated and demonstrates physiology not apparent with conventional CPET... In this study, we have shown that MR-CPET allows assessment of the differing contributions of CO and ΔcO2 to variation in peak VO2.

No MeSH data available.