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Is signal intensity of late gadolinium enhancement a substitute for extracellular volume mapping in acute myocardial infarction?

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Extracellular volume (ECV) calculated from T1 maps can quantitatively characterize myocardial tissue, including the severity of tissue damage in myocardial infarction (MI) (1)... An alternative approach for measuring the density of MI may be to calculate the relative signal intensity of LGE images.) A direct comparison of signal intensity of LGE and ECV in MI has not been carried out... We aimed to compare these two parameters in patients presenting with acute myocardial infarction... Twenty-nine patients underwent CMR examination at 3T (Intera CV, Philips Healthcare, Best, The Netherlands) within 3 days following reperfused ST-elevation acute MI... Cine, pre and 15 minute post-contrast MOLLI (3(3s)3(3s)5) for ECV-mapping and LGE imaging (0.1 mmol/kg gadolinium DTPA) were performed... We computed relative ECV for the infarct zone using the formula = iECV-rECV)/rECV; where iECV is infarct-ECV and rECV is remote-myocardial-ECV... Patient characteristics of the 29 patients are as follows: mean age 57±28 years old; 82.8% males (n=24); 24% (n=7) had hypertension; 27.6% (n=8) had hypercholesterolemia; 55% (n=16) were smoker and 13.8% (n=4) had diabetes mellitus... CMR based parameters are as follows: ejection fraction (LVEF) 49±9%; infarct volume on LGE 15.9±11.8mls; iECV 53.4±12.1%; rECV 30±6%... There was significant difference in iECV to rECV (p<0.001)... The volume of infarct was correlated to iECV (r=0.56; p=0.002) and also to relative ECV(r=0.45;p<0.05)... There was no correlation of signal intensity of LGE in the infarct zone to the iECV (r=0.07; p=0.72) and to relative ECV(r=0.17;p=0.37) (Figure 2)... The homogeneity of the signal intensity was also not related to iECV (r=0.14; p=0.45) and relative ECV (r= 0.18; p=0.35).

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Scatter plot of correlation of infarct ECV to the signal intensity of LGE and to the infarct volume.
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Fig2: Scatter plot of correlation of infarct ECV to the signal intensity of LGE and to the infarct volume.

Mentions: Patient characteristics of the 29 patients are as follows: mean age 57±28 years old; 82.8% males (n=24); 24% (n=7) had hypertension; 27.6% (n=8) had hypercholesterolemia; 55% (n=16) were smoker and 13.8% (n=4) had diabetes mellitus. CMR based parameters are as follows: ejection fraction (LVEF) 49±9%; infarct volume on LGE 15.9±11.8mls; iECV 53.4±12.1%; rECV 30±6%. There was significant difference in iECV to rECV (p<0.001). The volume of infarct was correlated to iECV (r=0.56; p=0.002) and also to relative ECV(r=0.45;p<0.05). There was no correlation of signal intensity of LGE in the infarct zone to the iECV (r=0.07; p=0.72) and to relative ECV(r=0.17;p=0.37) (Figure 2). The homogeneity of the signal intensity was also not related to iECV (r=0.14; p=0.45) and relative ECV (r= 0.18; p=0.35).Figure 2


Is signal intensity of late gadolinium enhancement a substitute for extracellular volume mapping in acute myocardial infarction?
Scatter plot of correlation of infarct ECV to the signal intensity of LGE and to the infarct volume.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328951&req=5

Fig2: Scatter plot of correlation of infarct ECV to the signal intensity of LGE and to the infarct volume.
Mentions: Patient characteristics of the 29 patients are as follows: mean age 57±28 years old; 82.8% males (n=24); 24% (n=7) had hypertension; 27.6% (n=8) had hypercholesterolemia; 55% (n=16) were smoker and 13.8% (n=4) had diabetes mellitus. CMR based parameters are as follows: ejection fraction (LVEF) 49±9%; infarct volume on LGE 15.9±11.8mls; iECV 53.4±12.1%; rECV 30±6%. There was significant difference in iECV to rECV (p<0.001). The volume of infarct was correlated to iECV (r=0.56; p=0.002) and also to relative ECV(r=0.45;p<0.05). There was no correlation of signal intensity of LGE in the infarct zone to the iECV (r=0.07; p=0.72) and to relative ECV(r=0.17;p=0.37) (Figure 2). The homogeneity of the signal intensity was also not related to iECV (r=0.14; p=0.45) and relative ECV (r= 0.18; p=0.35).Figure 2

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Extracellular volume (ECV) calculated from T1 maps can quantitatively characterize myocardial tissue, including the severity of tissue damage in myocardial infarction (MI) (1)... An alternative approach for measuring the density of MI may be to calculate the relative signal intensity of LGE images.) A direct comparison of signal intensity of LGE and ECV in MI has not been carried out... We aimed to compare these two parameters in patients presenting with acute myocardial infarction... Twenty-nine patients underwent CMR examination at 3T (Intera CV, Philips Healthcare, Best, The Netherlands) within 3 days following reperfused ST-elevation acute MI... Cine, pre and 15 minute post-contrast MOLLI (3(3s)3(3s)5) for ECV-mapping and LGE imaging (0.1 mmol/kg gadolinium DTPA) were performed... We computed relative ECV for the infarct zone using the formula = iECV-rECV)/rECV; where iECV is infarct-ECV and rECV is remote-myocardial-ECV... Patient characteristics of the 29 patients are as follows: mean age 57±28 years old; 82.8% males (n=24); 24% (n=7) had hypertension; 27.6% (n=8) had hypercholesterolemia; 55% (n=16) were smoker and 13.8% (n=4) had diabetes mellitus... CMR based parameters are as follows: ejection fraction (LVEF) 49±9%; infarct volume on LGE 15.9±11.8mls; iECV 53.4±12.1%; rECV 30±6%... There was significant difference in iECV to rECV (p<0.001)... The volume of infarct was correlated to iECV (r=0.56; p=0.002) and also to relative ECV(r=0.45;p<0.05)... There was no correlation of signal intensity of LGE in the infarct zone to the iECV (r=0.07; p=0.72) and to relative ECV(r=0.17;p=0.37) (Figure 2)... The homogeneity of the signal intensity was also not related to iECV (r=0.14; p=0.45) and relative ECV (r= 0.18; p=0.35).

No MeSH data available.


Related in: MedlinePlus