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Effect of late sodium current inhibition on MRI measured diastolic dysfunction and myocardial perfusion reserve in aortic stenosis: a pilot study

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The presence of LVH, diastolic dysfunction and microvascular dysfunction appear to be important determinants of exercise capacity in AS... In this prospective, open label study with blinded endpoint analysis, patients with asymptomatic moderate/severe AS and diastolic dysfunction or LVH were recruited... Tagged images were acquired at three short-axis slices on a 3T platform (Siemens Skyra)... Myocardial perfusion reserve was calculated from stress and resting blood flow... The primary hypothesis was that Ranolazine would improve peak early diastolic strain rate (PEDSR) on tagged MRI... Fifteen patients (PPG 48.8±12.4 mmHg, MPG 27.1±7.5 mmHg, AVA 1.26±0.31 cm, LV mass index 66.72±15.35 g/m) completed the week-6 visit and 13 completed the final visit... Results are shown in table 1... There was a trend for the global PEDSR to increase from the baseline to week-6 (0.79 ± 0.15 to 0.86 ± 0.18, p=0.198)... For those who completed the final visit, PEDSR increased from baseline to week-6 and then returned close to the baseline value at week-10 (table)... On splitting the patients into low and high-MPR subgroups based on the median MPR, the trend for the improvement in PEDSR (0.88 ± 0.80, 1.03 ± 0 .30, 0.86 ± 0.15) and reduction in exercise LVRPP was maintained in the low-MPR subgroup only... The current results would support a larger study in patients with diastolic dysfunction.

No MeSH data available.


a.)Trend in PEDSR with study visit for the Basal slice, b.) Total exercise duration for all patients exercised at each visit (p=0.07 for baseline vs week-6, p=0.73 for week-6 vs week-10)
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Figure 1: a.)Trend in PEDSR with study visit for the Basal slice, b.) Total exercise duration for all patients exercised at each visit (p=0.07 for baseline vs week-6, p=0.73 for week-6 vs week-10)


Effect of late sodium current inhibition on MRI measured diastolic dysfunction and myocardial perfusion reserve in aortic stenosis: a pilot study
a.)Trend in PEDSR with study visit for the Basal slice, b.) Total exercise duration for all patients exercised at each visit (p=0.07 for baseline vs week-6, p=0.73 for week-6 vs week-10)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328948&req=5

Figure 1: a.)Trend in PEDSR with study visit for the Basal slice, b.) Total exercise duration for all patients exercised at each visit (p=0.07 for baseline vs week-6, p=0.73 for week-6 vs week-10)

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The presence of LVH, diastolic dysfunction and microvascular dysfunction appear to be important determinants of exercise capacity in AS... In this prospective, open label study with blinded endpoint analysis, patients with asymptomatic moderate/severe AS and diastolic dysfunction or LVH were recruited... Tagged images were acquired at three short-axis slices on a 3T platform (Siemens Skyra)... Myocardial perfusion reserve was calculated from stress and resting blood flow... The primary hypothesis was that Ranolazine would improve peak early diastolic strain rate (PEDSR) on tagged MRI... Fifteen patients (PPG 48.8±12.4 mmHg, MPG 27.1±7.5 mmHg, AVA 1.26±0.31 cm, LV mass index 66.72±15.35 g/m) completed the week-6 visit and 13 completed the final visit... Results are shown in table 1... There was a trend for the global PEDSR to increase from the baseline to week-6 (0.79 ± 0.15 to 0.86 ± 0.18, p=0.198)... For those who completed the final visit, PEDSR increased from baseline to week-6 and then returned close to the baseline value at week-10 (table)... On splitting the patients into low and high-MPR subgroups based on the median MPR, the trend for the improvement in PEDSR (0.88 ± 0.80, 1.03 ± 0 .30, 0.86 ± 0.15) and reduction in exercise LVRPP was maintained in the low-MPR subgroup only... The current results would support a larger study in patients with diastolic dysfunction.

No MeSH data available.