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Assessment of MRI parameters for studying brain development in newborns with congenital heart disease

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Microstructural evidence of white matter (WM) dysmaturation in the brains of newborns with congenital heart disease (CHD) using MRI has been previously shown... The N-acetyl acetate to choline (NAA/Chol) ratio was calculated from the MRS of the centrum semiovale... Regions of interest for analysis of T2, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) included inferior frontal, superior frontal and parietal WM... The ADC values decreased with age but were higher in CHD newborns than in controls (Fig. 1B)... The T2 brain maps of CHD newborns showed visual differences in comparison to controls of similar age (Fig. 1C-D)... Table 1 summarizes all the results... As expected, WM ADC values in CHD newborns were significantly higher than controls... We also found a reduction in brain volume in newborns with CHD, similar to the results of other groups... In unmyelinated WM regions, FA and NAA/Chol ratios were not significantly different... Whereas, WM T2 was significantly higher in CHD newborns, despite the smaller number of studies that incorporated T2 mapping... WM T2 may be a sensitive marker of WM dysmaturation in the setting of CHD and a useful adjunct to more established parameters in the assessment of the impact of fetal interventions on brain development.

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Comparison of brain volumes (A.) and inferior frontal WM ADC (B.) versus corrected gestational age (GA) between CHD newborns and controls. Visual comparison of brain T2 maps at the same window level of inferior frontal WM in a control (C.) to a CHD newborn (D.). Both the normal and CHD newborn were of the same age, 39 weeks corrected GA.
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Fig1: Comparison of brain volumes (A.) and inferior frontal WM ADC (B.) versus corrected gestational age (GA) between CHD newborns and controls. Visual comparison of brain T2 maps at the same window level of inferior frontal WM in a control (C.) to a CHD newborn (D.). Both the normal and CHD newborn were of the same age, 39 weeks corrected GA.

Mentions: There was no significant difference between the corrected gestational ages of the two groups (p=0.88). Brain volume increased with age but was lower in CHD newborns than controls (Fig. 1A). The ADC values decreased with age but were higher in CHD newborns than in controls (Fig. 1B). FA and NAA/Chol ratios both increased with age but were not significantly different between the two groups. T2s decreased with age and the average WM T2s of CHD newborns were higher than controls. The T2 brain maps of CHD newborns showed visual differences in comparison to controls of similar age (Fig. 1C-D). Table 1 summarizes all the results.Figure 1


Assessment of MRI parameters for studying brain development in newborns with congenital heart disease
Comparison of brain volumes (A.) and inferior frontal WM ADC (B.) versus corrected gestational age (GA) between CHD newborns and controls. Visual comparison of brain T2 maps at the same window level of inferior frontal WM in a control (C.) to a CHD newborn (D.). Both the normal and CHD newborn were of the same age, 39 weeks corrected GA.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328917&req=5

Fig1: Comparison of brain volumes (A.) and inferior frontal WM ADC (B.) versus corrected gestational age (GA) between CHD newborns and controls. Visual comparison of brain T2 maps at the same window level of inferior frontal WM in a control (C.) to a CHD newborn (D.). Both the normal and CHD newborn were of the same age, 39 weeks corrected GA.
Mentions: There was no significant difference between the corrected gestational ages of the two groups (p=0.88). Brain volume increased with age but was lower in CHD newborns than controls (Fig. 1A). The ADC values decreased with age but were higher in CHD newborns than in controls (Fig. 1B). FA and NAA/Chol ratios both increased with age but were not significantly different between the two groups. T2s decreased with age and the average WM T2s of CHD newborns were higher than controls. The T2 brain maps of CHD newborns showed visual differences in comparison to controls of similar age (Fig. 1C-D). Table 1 summarizes all the results.Figure 1

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Microstructural evidence of white matter (WM) dysmaturation in the brains of newborns with congenital heart disease (CHD) using MRI has been previously shown... The N-acetyl acetate to choline (NAA/Chol) ratio was calculated from the MRS of the centrum semiovale... Regions of interest for analysis of T2, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) included inferior frontal, superior frontal and parietal WM... The ADC values decreased with age but were higher in CHD newborns than in controls (Fig. 1B)... The T2 brain maps of CHD newborns showed visual differences in comparison to controls of similar age (Fig. 1C-D)... Table 1 summarizes all the results... As expected, WM ADC values in CHD newborns were significantly higher than controls... We also found a reduction in brain volume in newborns with CHD, similar to the results of other groups... In unmyelinated WM regions, FA and NAA/Chol ratios were not significantly different... Whereas, WM T2 was significantly higher in CHD newborns, despite the smaller number of studies that incorporated T2 mapping... WM T2 may be a sensitive marker of WM dysmaturation in the setting of CHD and a useful adjunct to more established parameters in the assessment of the impact of fetal interventions on brain development.

No MeSH data available.


Related in: MedlinePlus