Limits...
Prognostic significance of quantitative measures of myocardial infarct pathology using native T1 mapping, in survivors of ST-elevation myocardial infarction

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

We aimed to assess the clinical significance of infarct tissue characteristics using native T1 cardiac magnetic resonance (CMR)... All-cause death or heart failure hospitalization was a pre-specified outcome that was assessed during follow-up. 300 STEMI patients (mean±SD age 59±12 years, 74% male, 114 with anterior STEMI) gave informed consent and had CMR (14 July 2011 - 22 November 2012)... Native T1 within the area-at-risk (1097 ±52 ms) was higher than in the remote zone (961 ±25 ms; p<0.01) or infarct core (996.9 (57.3); p<0.01)... In multivariable linear regression, native T1 in the area-at-risk was independently and negatively associated with age, initial systolic blood pressure and TIMI coronary flow grade at presentation (all p<0.05), independent of LVEF, left ventricular end-diastolic volume (LVEDV) or infarct size... Similar findings were observed for T1 core values, which were also independently associated with Killip class... T1 in the infarct core was a multivariable predictor of adverse remodeling (-0.01 (-0.02, -0.00); p=0.048). 288 (100%) patients had longer term follow-up completed... The median duration of follow-up was 845 days... Thirty (10.4%) patients died or experienced a heart failure event and 13 (4.5%) of these patients died or experienced a heart failure hospitalization post-discharge... Native T1 in the area-at-risk was a predictor of all-cause death or heart failure post-discharge (hazard ratio 0.985, 95% CI 0.973, 0.997; p=0.012) including after adjustment for LVEF at baseline (p=0.018) and LVEDV at baseline (p=0.013)... In acute STEMI patients, infarct zone tissue characteristics predict left ventricular remodeling and long-term health outcomes, independent of infarct size and LV function.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier survival plot (n = 288) for all-cause death or heart failure hospitalisation by T1 injured median.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4328908&req=5

Figure 1: Kaplan-Meier survival plot (n = 288) for all-cause death or heart failure hospitalisation by T1 injured median.


Prognostic significance of quantitative measures of myocardial infarct pathology using native T1 mapping, in survivors of ST-elevation myocardial infarction
Kaplan-Meier survival plot (n = 288) for all-cause death or heart failure hospitalisation by T1 injured median.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328908&req=5

Figure 1: Kaplan-Meier survival plot (n = 288) for all-cause death or heart failure hospitalisation by T1 injured median.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

We aimed to assess the clinical significance of infarct tissue characteristics using native T1 cardiac magnetic resonance (CMR)... All-cause death or heart failure hospitalization was a pre-specified outcome that was assessed during follow-up. 300 STEMI patients (mean±SD age 59±12 years, 74% male, 114 with anterior STEMI) gave informed consent and had CMR (14 July 2011 - 22 November 2012)... Native T1 within the area-at-risk (1097 ±52 ms) was higher than in the remote zone (961 ±25 ms; p<0.01) or infarct core (996.9 (57.3); p<0.01)... In multivariable linear regression, native T1 in the area-at-risk was independently and negatively associated with age, initial systolic blood pressure and TIMI coronary flow grade at presentation (all p<0.05), independent of LVEF, left ventricular end-diastolic volume (LVEDV) or infarct size... Similar findings were observed for T1 core values, which were also independently associated with Killip class... T1 in the infarct core was a multivariable predictor of adverse remodeling (-0.01 (-0.02, -0.00); p=0.048). 288 (100%) patients had longer term follow-up completed... The median duration of follow-up was 845 days... Thirty (10.4%) patients died or experienced a heart failure event and 13 (4.5%) of these patients died or experienced a heart failure hospitalization post-discharge... Native T1 in the area-at-risk was a predictor of all-cause death or heart failure post-discharge (hazard ratio 0.985, 95% CI 0.973, 0.997; p=0.012) including after adjustment for LVEF at baseline (p=0.018) and LVEDV at baseline (p=0.013)... In acute STEMI patients, infarct zone tissue characteristics predict left ventricular remodeling and long-term health outcomes, independent of infarct size and LV function.

No MeSH data available.


Related in: MedlinePlus