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Single breathhold, three-dimensional measurement of left atrial volume and function using sparse CINE CMR imaging with iterative reconstruction

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A highly accelerated prototype cine sequence with sparse sampling and Iterative Reconstruction (sCINE-IR) was used in phantoms and patients to acquire 5 cine slices (2 long axis, LAX and 3 short axis, SAX) through the LA during a single breathhold yielding a spatial/temporal resolution of 1.5mm/30ms (1.5T Aera, Siemens AG, Germany)... Patients study... Three patients were scanned with both 3D-HR and sCINE-IR... The volumes obtained with 3D-HR and with sCINE-IR during the corresponding mid-diastolic frame were compared using Bland-Altman method and linear regression... Phantom study... The calculated volumes were not significantly different when different orientations of the sCINE-IR slices were planned (LAX aligned vs not aligned with the true LA long axis, SAX parallel vs not parallel to the mitral plane, p=ns for both)... Reference LA volumes were obtained with 3D-HR in 3 patients aged 23-80 years (63ml, 62ml and 395ml). sCINE-IR -calculated volumes of the mid-diastolic frame matched closely the reference volume with a difference of 2.7±6.5ml (2.7% underestimation, R=0.99)... Complete time-volume curves of the LAs were obtained for each patient, allowing to assess LA phasic function (Figure)... With this new method of a highly accelerated sCINE-IR acquisition followed by a 3D non-model based reconstruction, LA volumes could be accurately measured from 5 cine slices acquired during one single breath hold... This method opens the possibility to precisely measure LA function over time... The reproducibility of this new technique needs to be assessed on a larger patient cohort.

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LA volume reconstruction using a sCINE-IR acquisition. Left : sCINE-IR acquisitions through the LA. Images a and b correspond to SAX and images c,d and e to SAX. Middle : the 3D-reconstructed LA volumes (red casts) are shown at 5 different time points during the cardiac cycle, oriented perpendicular to the mitral valve to illustrate the mitral valve motion and lengthening and shortining of the LA long axis. Right : figure at the top illustrates the 5 contours at time point 4, used to reconstruct the LA volume at time point 4 (center right). At lower right, the LA volume curve is given over the entire cardiac cycle (I=LA passive emptying volume; II=LA active emptying volume; III=LA total reservoir volume)
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Figure 1: LA volume reconstruction using a sCINE-IR acquisition. Left : sCINE-IR acquisitions through the LA. Images a and b correspond to SAX and images c,d and e to SAX. Middle : the 3D-reconstructed LA volumes (red casts) are shown at 5 different time points during the cardiac cycle, oriented perpendicular to the mitral valve to illustrate the mitral valve motion and lengthening and shortining of the LA long axis. Right : figure at the top illustrates the 5 contours at time point 4, used to reconstruct the LA volume at time point 4 (center right). At lower right, the LA volume curve is given over the entire cardiac cycle (I=LA passive emptying volume; II=LA active emptying volume; III=LA total reservoir volume)


Single breathhold, three-dimensional measurement of left atrial volume and function using sparse CINE CMR imaging with iterative reconstruction
LA volume reconstruction using a sCINE-IR acquisition. Left : sCINE-IR acquisitions through the LA. Images a and b correspond to SAX and images c,d and e to SAX. Middle : the 3D-reconstructed LA volumes (red casts) are shown at 5 different time points during the cardiac cycle, oriented perpendicular to the mitral valve to illustrate the mitral valve motion and lengthening and shortining of the LA long axis. Right : figure at the top illustrates the 5 contours at time point 4, used to reconstruct the LA volume at time point 4 (center right). At lower right, the LA volume curve is given over the entire cardiac cycle (I=LA passive emptying volume; II=LA active emptying volume; III=LA total reservoir volume)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328896&req=5

Figure 1: LA volume reconstruction using a sCINE-IR acquisition. Left : sCINE-IR acquisitions through the LA. Images a and b correspond to SAX and images c,d and e to SAX. Middle : the 3D-reconstructed LA volumes (red casts) are shown at 5 different time points during the cardiac cycle, oriented perpendicular to the mitral valve to illustrate the mitral valve motion and lengthening and shortining of the LA long axis. Right : figure at the top illustrates the 5 contours at time point 4, used to reconstruct the LA volume at time point 4 (center right). At lower right, the LA volume curve is given over the entire cardiac cycle (I=LA passive emptying volume; II=LA active emptying volume; III=LA total reservoir volume)

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

A highly accelerated prototype cine sequence with sparse sampling and Iterative Reconstruction (sCINE-IR) was used in phantoms and patients to acquire 5 cine slices (2 long axis, LAX and 3 short axis, SAX) through the LA during a single breathhold yielding a spatial/temporal resolution of 1.5mm/30ms (1.5T Aera, Siemens AG, Germany)... Patients study... Three patients were scanned with both 3D-HR and sCINE-IR... The volumes obtained with 3D-HR and with sCINE-IR during the corresponding mid-diastolic frame were compared using Bland-Altman method and linear regression... Phantom study... The calculated volumes were not significantly different when different orientations of the sCINE-IR slices were planned (LAX aligned vs not aligned with the true LA long axis, SAX parallel vs not parallel to the mitral plane, p=ns for both)... Reference LA volumes were obtained with 3D-HR in 3 patients aged 23-80 years (63ml, 62ml and 395ml). sCINE-IR -calculated volumes of the mid-diastolic frame matched closely the reference volume with a difference of 2.7±6.5ml (2.7% underestimation, R=0.99)... Complete time-volume curves of the LAs were obtained for each patient, allowing to assess LA phasic function (Figure)... With this new method of a highly accelerated sCINE-IR acquisition followed by a 3D non-model based reconstruction, LA volumes could be accurately measured from 5 cine slices acquired during one single breath hold... This method opens the possibility to precisely measure LA function over time... The reproducibility of this new technique needs to be assessed on a larger patient cohort.

No MeSH data available.


Related in: MedlinePlus