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Towards high-resolution fat-suppressed T1-mapping of atrial fibrosis in the left atrium: a fit-free three-point method

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Atrial fibrosis identification by late gadolinium enhancement (LGE) CMR is important as a precursor to atrial fibrillation, and may impact the outcome of catheter ablation... The method requires 2 RR per inversion and employed TR/TE/Θ=4.0 ms/1.7ms/15deg, 30-40 segments per RR in ventricular diastole, 30 x24 cm FOV, 1.5 x 1.5 x 3 mm true spatial resolution, ~12 minutes total scan time for measurement with three TIs, assuming 50% NAV efficiency... Phantoms with a range of T1s (200-650ms), with T1 measured by spin echo inversion recovery (IR), were imaged to compare the performance of our standard T1-mapping with 6 TIs (100 to 500ms, ∞) estimated using least-squares fitting, to the fit-free 3-pt method... T1-maps of the left atrium were also obtained in a study of Yorkshire swine (n = 5) one to two weeks after myocardial infarction, ~30 minutes post injection of 0.2mmol/kg gadobutrol... Pre-contrast TIs from literature were used... Figure 1 compares the gold-standard T1s to the fit-free 3-pt method and the 6-pt method... The Bland-Altman analysis found a bias and 2SDs for the fit-free 3-pt values of 11±35ms, as compared with 3 ±17ms for the 6-pt method... Figure 2 shows T1-mapping in atria of a swine... The average ECV values for normal myocardium (26±3%) and the partially fibrotic valves (49±6%) were within the expected range... The 3-pt fit-free method is accurate for a narrow range of T1s, in a feasible but still lengthy scan time.

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A) T1 map of the left atrium, showing lower T1 in the valves (arrow head), which are known fibrotic structures, and in a section of the posterior LA wall (arrow). B) The TI=400ms image highlights the identical areas. Using, pre-contrast T1s from literature, the visible LV myocardium had an estimated ECV of 29%, and the valvular region had an ECV of 52%, which are reasonable values for normal, and partially fibrotic structures.
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Figure 2: A) T1 map of the left atrium, showing lower T1 in the valves (arrow head), which are known fibrotic structures, and in a section of the posterior LA wall (arrow). B) The TI=400ms image highlights the identical areas. Using, pre-contrast T1s from literature, the visible LV myocardium had an estimated ECV of 29%, and the valvular region had an ECV of 52%, which are reasonable values for normal, and partially fibrotic structures.

Mentions: Figure 1 compares the gold-standard T1s to the fit-free 3-pt method and the 6-pt method. The Bland-Altman analysis found a bias and 2SDs for the fit-free 3-pt values of 11±35ms, as compared with 3 ±17ms for the 6-pt method. Figure 2 shows T1-mapping in atria of a swine. The average ECV values for normal myocardium (26±3%) and the partially fibrotic valves (49±6%) were within the expected range.


Towards high-resolution fat-suppressed T1-mapping of atrial fibrosis in the left atrium: a fit-free three-point method
A) T1 map of the left atrium, showing lower T1 in the valves (arrow head), which are known fibrotic structures, and in a section of the posterior LA wall (arrow). B) The TI=400ms image highlights the identical areas. Using, pre-contrast T1s from literature, the visible LV myocardium had an estimated ECV of 29%, and the valvular region had an ECV of 52%, which are reasonable values for normal, and partially fibrotic structures.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4328894&req=5

Figure 2: A) T1 map of the left atrium, showing lower T1 in the valves (arrow head), which are known fibrotic structures, and in a section of the posterior LA wall (arrow). B) The TI=400ms image highlights the identical areas. Using, pre-contrast T1s from literature, the visible LV myocardium had an estimated ECV of 29%, and the valvular region had an ECV of 52%, which are reasonable values for normal, and partially fibrotic structures.
Mentions: Figure 1 compares the gold-standard T1s to the fit-free 3-pt method and the 6-pt method. The Bland-Altman analysis found a bias and 2SDs for the fit-free 3-pt values of 11±35ms, as compared with 3 ±17ms for the 6-pt method. Figure 2 shows T1-mapping in atria of a swine. The average ECV values for normal myocardium (26±3%) and the partially fibrotic valves (49±6%) were within the expected range.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Atrial fibrosis identification by late gadolinium enhancement (LGE) CMR is important as a precursor to atrial fibrillation, and may impact the outcome of catheter ablation... The method requires 2 RR per inversion and employed TR/TE/Θ=4.0 ms/1.7ms/15deg, 30-40 segments per RR in ventricular diastole, 30 x24 cm FOV, 1.5 x 1.5 x 3 mm true spatial resolution, ~12 minutes total scan time for measurement with three TIs, assuming 50% NAV efficiency... Phantoms with a range of T1s (200-650ms), with T1 measured by spin echo inversion recovery (IR), were imaged to compare the performance of our standard T1-mapping with 6 TIs (100 to 500ms, ∞) estimated using least-squares fitting, to the fit-free 3-pt method... T1-maps of the left atrium were also obtained in a study of Yorkshire swine (n = 5) one to two weeks after myocardial infarction, ~30 minutes post injection of 0.2mmol/kg gadobutrol... Pre-contrast TIs from literature were used... Figure 1 compares the gold-standard T1s to the fit-free 3-pt method and the 6-pt method... The Bland-Altman analysis found a bias and 2SDs for the fit-free 3-pt values of 11±35ms, as compared with 3 ±17ms for the 6-pt method... Figure 2 shows T1-mapping in atria of a swine... The average ECV values for normal myocardium (26±3%) and the partially fibrotic valves (49±6%) were within the expected range... The 3-pt fit-free method is accurate for a narrow range of T1s, in a feasible but still lengthy scan time.

No MeSH data available.