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Clear cell papillary renal cell carcinoma: a potential mimic of conventional clear cell renal carcinoma on core biopsy.

Liddell H, Mare A, Heywood S, Bennett G, Chan HF - Case Rep Urol (2015)

Bottom Line: Thought to only arise in those with end stage renal disease, CCP-RCC is increasingly identified in those without renal impairment.Immunohistochemically, these tumors are positive for CK7 and negative for CD10 and racemase.These tumours appear to be indolent in nature, with no current documented cases of metastatic spread.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Canberra Hospital, Garran, ACT 2605, Australia.

ABSTRACT
Clear cell papillary renal cell carcinoma (CCP-RCC) is a recently described, relatively uncommon variant of renal cell carcinoma (RCC) with a reported incidence of 4.1%. Thought to only arise in those with end stage renal disease, CCP-RCC is increasingly identified in those without renal impairment. CCP-RCCs have unique morphologic, genetic, and immunohistochemical features distinguishing them from both conventional clear cell renal cell carcinomas and papillary renal cell carcinomas. Immunohistochemically, these tumors are positive for CK7 and negative for CD10 and racemase. This is in contrast to conventional cell renal cell carcinomas (CK7 negative, CD10 positive) and papillary cell carcinomas (CK7, CD10, and racemase positive). These tumours appear to be indolent in nature, with no current documented cases of metastatic spread. We present the case of a 42-year-old female who presented with an incidental finding of a renal mass that on a core biopsy was reported as clear cell carcinoma, Fuhrman grade 1. She subsequently underwent a radical nephrectomy and further histological examination revealed the tumor to be a clear cell papillary renal cell carcinoma, Fuhrman grade 1.

No MeSH data available.


Related in: MedlinePlus

High power of biopsy showing area consistent with clear cell renal cell carcinoma.
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fig1: High power of biopsy showing area consistent with clear cell renal cell carcinoma.

Mentions: The renal mass was further characterized with a triple phase abdominal CT scan and this confirmed a 4 × 4.9 × 4.5 cm heterogenous mass in the upper pole of the left kidney. There was no evidence of left renal vein involvement nor was any radiologically significant lymphadenopathy seen. Her films were reviewed and the decision was made to biopsy the left renal mass to establish whether the lesion was neoplastic or inflammatory. A core biopsy of the left kidney was reported as a Fuhrman grade 1, clear cell renal cell carcinoma (Figure 1). She was then booked for an elective laparoscopic left radical nephrectomy. She underwent this procedure without complication and had an uneventful postoperative course subsequently being discharged home on day four.


Clear cell papillary renal cell carcinoma: a potential mimic of conventional clear cell renal carcinoma on core biopsy.

Liddell H, Mare A, Heywood S, Bennett G, Chan HF - Case Rep Urol (2015)

High power of biopsy showing area consistent with clear cell renal cell carcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325967&req=5

fig1: High power of biopsy showing area consistent with clear cell renal cell carcinoma.
Mentions: The renal mass was further characterized with a triple phase abdominal CT scan and this confirmed a 4 × 4.9 × 4.5 cm heterogenous mass in the upper pole of the left kidney. There was no evidence of left renal vein involvement nor was any radiologically significant lymphadenopathy seen. Her films were reviewed and the decision was made to biopsy the left renal mass to establish whether the lesion was neoplastic or inflammatory. A core biopsy of the left kidney was reported as a Fuhrman grade 1, clear cell renal cell carcinoma (Figure 1). She was then booked for an elective laparoscopic left radical nephrectomy. She underwent this procedure without complication and had an uneventful postoperative course subsequently being discharged home on day four.

Bottom Line: Thought to only arise in those with end stage renal disease, CCP-RCC is increasingly identified in those without renal impairment.Immunohistochemically, these tumors are positive for CK7 and negative for CD10 and racemase.These tumours appear to be indolent in nature, with no current documented cases of metastatic spread.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Canberra Hospital, Garran, ACT 2605, Australia.

ABSTRACT
Clear cell papillary renal cell carcinoma (CCP-RCC) is a recently described, relatively uncommon variant of renal cell carcinoma (RCC) with a reported incidence of 4.1%. Thought to only arise in those with end stage renal disease, CCP-RCC is increasingly identified in those without renal impairment. CCP-RCCs have unique morphologic, genetic, and immunohistochemical features distinguishing them from both conventional clear cell renal cell carcinomas and papillary renal cell carcinomas. Immunohistochemically, these tumors are positive for CK7 and negative for CD10 and racemase. This is in contrast to conventional cell renal cell carcinomas (CK7 negative, CD10 positive) and papillary cell carcinomas (CK7, CD10, and racemase positive). These tumours appear to be indolent in nature, with no current documented cases of metastatic spread. We present the case of a 42-year-old female who presented with an incidental finding of a renal mass that on a core biopsy was reported as clear cell carcinoma, Fuhrman grade 1. She subsequently underwent a radical nephrectomy and further histological examination revealed the tumor to be a clear cell papillary renal cell carcinoma, Fuhrman grade 1.

No MeSH data available.


Related in: MedlinePlus