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Fatigue in multiple sclerosis: a look at the role of poor sleep.

Strober LB - Front Neurol (2015)

Bottom Line: Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance).Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently.A replication of this author's and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance.

View Article: PubMed Central - PubMed

Affiliation: Neuropsychology and Neuroscience Laboratory, Kessler Foundation , West Orange, NJ , USA ; New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, NJ , USA.

ABSTRACT
Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literature and clinical care for decades. With regard to its etiology, MS-related fatigue has been construed as being either primary or secondary. Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance). The present paper focuses on secondary fatigue and the role of sleep disturbance, in particular. Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently. The present paper provides a brief review of the literature pertaining to the prevalence and nature of sleep problems in MS as well as their association with fatigue. A replication of this author's and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance.

No MeSH data available.


Related in: MedlinePlus

Number of articles published in PubMed with the words “sleep” and “multiple sclerosis” in the title.
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Figure 1: Number of articles published in PubMed with the words “sleep” and “multiple sclerosis” in the title.

Mentions: Despite being the most obvious factor, sleep disturbance or disorders, had initially received fairly little attention as a precipitating or exacerbating factor of fatigue in MS. Fortunately, following an editorial by Attarian titled, “Importance of sleep in the quality of life of multiple sclerosis patients: a long under-recognized issue” sleep disturbance and its disorders have received significantly more attention (4). In fact, when conducting a PubMed search with the terms “MS” and “sleep” in the title, 14 articles have been published between the years 1987 and 1997 and 15 articles were dated from 1998 to 2008, suggesting approximately 15 published articles on sleep in MS per decade. However, since Attarian’s editorial in 2009 the number of published articles with MS and sleep in the title is 46. Thus, at this rate, the number of published articles on sleep in MS over the past 5 years is one a half times more than what was published in the preceding two decades of the 2009 editorial (see Figure 1).


Fatigue in multiple sclerosis: a look at the role of poor sleep.

Strober LB - Front Neurol (2015)

Number of articles published in PubMed with the words “sleep” and “multiple sclerosis” in the title.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325921&req=5

Figure 1: Number of articles published in PubMed with the words “sleep” and “multiple sclerosis” in the title.
Mentions: Despite being the most obvious factor, sleep disturbance or disorders, had initially received fairly little attention as a precipitating or exacerbating factor of fatigue in MS. Fortunately, following an editorial by Attarian titled, “Importance of sleep in the quality of life of multiple sclerosis patients: a long under-recognized issue” sleep disturbance and its disorders have received significantly more attention (4). In fact, when conducting a PubMed search with the terms “MS” and “sleep” in the title, 14 articles have been published between the years 1987 and 1997 and 15 articles were dated from 1998 to 2008, suggesting approximately 15 published articles on sleep in MS per decade. However, since Attarian’s editorial in 2009 the number of published articles with MS and sleep in the title is 46. Thus, at this rate, the number of published articles on sleep in MS over the past 5 years is one a half times more than what was published in the preceding two decades of the 2009 editorial (see Figure 1).

Bottom Line: Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance).Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently.A replication of this author's and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance.

View Article: PubMed Central - PubMed

Affiliation: Neuropsychology and Neuroscience Laboratory, Kessler Foundation , West Orange, NJ , USA ; New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, NJ , USA.

ABSTRACT
Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literature and clinical care for decades. With regard to its etiology, MS-related fatigue has been construed as being either primary or secondary. Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance). The present paper focuses on secondary fatigue and the role of sleep disturbance, in particular. Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently. The present paper provides a brief review of the literature pertaining to the prevalence and nature of sleep problems in MS as well as their association with fatigue. A replication of this author's and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance.

No MeSH data available.


Related in: MedlinePlus