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Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia.

Soennesyn H, Dalen I, Aarsland D - Dement Geriatr Cogn Dis Extra (2014)

Bottom Line: Patients with OH at both baseline and the 1-year follow-up were classified as having persistent OH.From baseline to the 4-year follow-up, 30-45% of the participants had OH at each follow-up.OH was moderately prevalent over 4 years in older individuals with mild dementia, and persistent OH did not predict either cognitive or functional decline or survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.

ABSTRACT

Aim: To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia.

Methods: Referrals to outpatient clinics specialising in old age psychiatry and geriatric medicine in the counties of Rogaland and Hordaland in western Norway with a first-time diagnosis of mild dementia were consecutively asked for inclusion. A total of 211 participants underwent a comprehensive baseline assessment with annual follow-ups. Patients with OH at both baseline and the 1-year follow-up were classified as having persistent OH. Outcome measures were the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating sum of boxes (CDR-SB), and time to death.

Results: From baseline to the 4-year follow-up, 30-45% of the participants had OH at each follow-up. In multivariable analysis, persistent OH was not significantly associated with either the longitudinal course of MMSE or CDR-SB scores or survival.

Conclusions: OH was moderately prevalent over 4 years in older individuals with mild dementia, and persistent OH did not predict either cognitive or functional decline or survival.

No MeSH data available.


Related in: MedlinePlus

Box plot of MMSE scores from baseline (BL) to 4-year follow-up (FU4). Light grey: patients with OH at each examination. Dark grey: patients without OH at each examination.
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Figure 3: Box plot of MMSE scores from baseline (BL) to 4-year follow-up (FU4). Light grey: patients with OH at each examination. Dark grey: patients without OH at each examination.

Mentions: Cognitive and general function declined as expected, as was measured with the MMSE and the CDR-SB. At the 4-year follow-up, the median MMSE score was 15.0 (IQR: 10.0-22.8) and the median CDR-SB score 13.0 (IQR: 8.4-15.3) among those having two OH measurements from baseline to the 1-year follow-up. The corresponding values for those without two OH measurements were 15.5 (IQR: 8.0-20.0) and 13.0 (IQR: 10.0-15.5). There were no significant differences between those with and those without OH regarding MMSE scores (fig. 3) or CDR-SB scores (fig. 4) at baseline or at any of the follow-up examinations (all t test p values ≥0.093).


Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia.

Soennesyn H, Dalen I, Aarsland D - Dement Geriatr Cogn Dis Extra (2014)

Box plot of MMSE scores from baseline (BL) to 4-year follow-up (FU4). Light grey: patients with OH at each examination. Dark grey: patients without OH at each examination.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325905&req=5

Figure 3: Box plot of MMSE scores from baseline (BL) to 4-year follow-up (FU4). Light grey: patients with OH at each examination. Dark grey: patients without OH at each examination.
Mentions: Cognitive and general function declined as expected, as was measured with the MMSE and the CDR-SB. At the 4-year follow-up, the median MMSE score was 15.0 (IQR: 10.0-22.8) and the median CDR-SB score 13.0 (IQR: 8.4-15.3) among those having two OH measurements from baseline to the 1-year follow-up. The corresponding values for those without two OH measurements were 15.5 (IQR: 8.0-20.0) and 13.0 (IQR: 10.0-15.5). There were no significant differences between those with and those without OH regarding MMSE scores (fig. 3) or CDR-SB scores (fig. 4) at baseline or at any of the follow-up examinations (all t test p values ≥0.093).

Bottom Line: Patients with OH at both baseline and the 1-year follow-up were classified as having persistent OH.From baseline to the 4-year follow-up, 30-45% of the participants had OH at each follow-up.OH was moderately prevalent over 4 years in older individuals with mild dementia, and persistent OH did not predict either cognitive or functional decline or survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.

ABSTRACT

Aim: To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia.

Methods: Referrals to outpatient clinics specialising in old age psychiatry and geriatric medicine in the counties of Rogaland and Hordaland in western Norway with a first-time diagnosis of mild dementia were consecutively asked for inclusion. A total of 211 participants underwent a comprehensive baseline assessment with annual follow-ups. Patients with OH at both baseline and the 1-year follow-up were classified as having persistent OH. Outcome measures were the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating sum of boxes (CDR-SB), and time to death.

Results: From baseline to the 4-year follow-up, 30-45% of the participants had OH at each follow-up. In multivariable analysis, persistent OH was not significantly associated with either the longitudinal course of MMSE or CDR-SB scores or survival.

Conclusions: OH was moderately prevalent over 4 years in older individuals with mild dementia, and persistent OH did not predict either cognitive or functional decline or survival.

No MeSH data available.


Related in: MedlinePlus