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The effect of low-frequency sound stimulation on patients with fibromyalgia: a clinical study.

Naghdi L, Ahonen H, Macario P, Bartel L - Pain Res Manag (2014)

Bottom Line: The search for effective treatments for fibromyalgia (FM) has continued for years.Medication dose was reduced in 73.68% of patients and completely discontinued in 26.32%.Time sitting and standing without pain increased significantly (P<0.0001).

View Article: PubMed Central - PubMed

ABSTRACT

Background: The search for effective treatments for fibromyalgia (FM) has continued for years. The present study premises that thalamocortical dysrhythmia is implicated in fibromyalgia and that low-frequency sound stimulation (LFSS) can play a regulatory function by driving neural rhythmic oscillatory activity.

Objective: To assess the effect of LFSS on FM.

Method: The present open-label study with no control group used a repeated-measures design with no noncompleters. Nineteen female volunteers (median age 51 years; median duration of FM 5.76 years) were administered 10 treatments (twice per week for five weeks). Treatments involved 23 min of LFSS at 40 Hz, delivered using transducers in a supine position. Measures (repeated before and after treatment) included the Fibromyalgia Impact Questionnaire, Jenkins Sleep Scale, Pain Disability Index, sitting and standing without pain (in minutes), cervical muscle range of motion and muscle tone. Mean percentages were calculated on end of treatment self-reports of improvement on pain, mood, insomnia and activities of daily living.

Results: Significant improvements were observed with median scores: Fibromyalgia Impact Questionnaire, 81% (P<0.0001); Jenkins Sleep Scale, 90% (P<0.0001); and Pain Disability Index, 49.1% (P<0.0001). Medication dose was reduced in 73.68% of patients and completely discontinued in 26.32%. Time sitting and standing without pain increased significantly (P<0.0001). Cervical muscle range of motion increased from 25% to 75% (P=0.001), while muscle tone changed from hypertonic to normal (P=0.0002).

Conclusion: In the present study, the LFSS treatment showed no adverse effects and patients receiving the LFSS treatment showed statistically and clinically relevant improvement. Further phase 2 and 3 trials are warranted.

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Related in: MedlinePlus

Range of motion (ROM) before and after treatment
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f5-prm-20-e21: Range of motion (ROM) before and after treatment

Mentions: Table 5 presents the changes in cervical ROM and cervical tone before and after treatment. Figure 5 shows that most patients (11 of 19) had 25% ROM and none had full ROM at baseline, while nine of 19 patients had >75% ROM and only three of 19 had <25% ROM after treatment. Similarly, Figure 6 shows that 13 of 19 patients were more hypertonic and none had normal tone at baseline, while there were seven patients with normal tone, six who were hypertonic and none who were more hypertonic after treatment.


The effect of low-frequency sound stimulation on patients with fibromyalgia: a clinical study.

Naghdi L, Ahonen H, Macario P, Bartel L - Pain Res Manag (2014)

Range of motion (ROM) before and after treatment
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325896&req=5

f5-prm-20-e21: Range of motion (ROM) before and after treatment
Mentions: Table 5 presents the changes in cervical ROM and cervical tone before and after treatment. Figure 5 shows that most patients (11 of 19) had 25% ROM and none had full ROM at baseline, while nine of 19 patients had >75% ROM and only three of 19 had <25% ROM after treatment. Similarly, Figure 6 shows that 13 of 19 patients were more hypertonic and none had normal tone at baseline, while there were seven patients with normal tone, six who were hypertonic and none who were more hypertonic after treatment.

Bottom Line: The search for effective treatments for fibromyalgia (FM) has continued for years.Medication dose was reduced in 73.68% of patients and completely discontinued in 26.32%.Time sitting and standing without pain increased significantly (P<0.0001).

View Article: PubMed Central - PubMed

ABSTRACT

Background: The search for effective treatments for fibromyalgia (FM) has continued for years. The present study premises that thalamocortical dysrhythmia is implicated in fibromyalgia and that low-frequency sound stimulation (LFSS) can play a regulatory function by driving neural rhythmic oscillatory activity.

Objective: To assess the effect of LFSS on FM.

Method: The present open-label study with no control group used a repeated-measures design with no noncompleters. Nineteen female volunteers (median age 51 years; median duration of FM 5.76 years) were administered 10 treatments (twice per week for five weeks). Treatments involved 23 min of LFSS at 40 Hz, delivered using transducers in a supine position. Measures (repeated before and after treatment) included the Fibromyalgia Impact Questionnaire, Jenkins Sleep Scale, Pain Disability Index, sitting and standing without pain (in minutes), cervical muscle range of motion and muscle tone. Mean percentages were calculated on end of treatment self-reports of improvement on pain, mood, insomnia and activities of daily living.

Results: Significant improvements were observed with median scores: Fibromyalgia Impact Questionnaire, 81% (P<0.0001); Jenkins Sleep Scale, 90% (P<0.0001); and Pain Disability Index, 49.1% (P<0.0001). Medication dose was reduced in 73.68% of patients and completely discontinued in 26.32%. Time sitting and standing without pain increased significantly (P<0.0001). Cervical muscle range of motion increased from 25% to 75% (P=0.001), while muscle tone changed from hypertonic to normal (P=0.0002).

Conclusion: In the present study, the LFSS treatment showed no adverse effects and patients receiving the LFSS treatment showed statistically and clinically relevant improvement. Further phase 2 and 3 trials are warranted.

Show MeSH
Related in: MedlinePlus