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Is intra-articular magnesium effective for postoperative analgesia in arthroscopic shoulder surgery?

Saritas TB, Borazan H, Okesli S, Yel M, Otelcioglu Ş - Pain Res Manag (2014)

Bottom Line: The analgesic effect was estimated using a visual analogue scale 1 h, 2 h, 6 h, 8 h, 12 h, 18 h and 24 h after operation.Total diclofenac consumption and intra-articular morphine + bupivacaine consumption were significantly lower in group M.Postoperative serum magnesium levels were significantly higher in group M, but were within the normal range.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Various medications are used intra-articularly for postoperative pain reduction after arthroscopic shoulder surgery. Magnesium, a N-methyl-D-aspartate receptor antagonist, may be effective for reduction of both postoperative pain scores and analgesic requirements.

Methods: A total of 67 patients undergoing arthroscopic shoulder surgery were divided randomly into two groups to receive intra-articular injections of either 10 mL magnesium sulphate (100 mg⁄mL; group M, n=34) or 10 mL of normal saline (group C, n=33). The analgesic effect was estimated using a visual analogue scale 1 h, 2 h, 6 h, 8 h, 12 h, 18 h and 24 h after operation. Postoperative analgesia was maintained by intra-articular morphine (0.01%, 10 mg) + bupivacaine (0.5%, 100 mL) patient-controlled analgesia device as a 1 mL infusion with a 1 mL bolus dose and 15 min lock-out time; for visual analogue scale scores >5, intramuscular diclofenac sodium 75 mg was administered as needed during the study period (maximum two times).

Results: Intra-articular magnesium resulted in a significant reduction in pain scores in group M compared with group C 1 h, 2 h, 6 h, 8 h and 12 h after the end of surgery, respectively, at rest and with passive motion. Total diclofenac consumption and intra-articular morphine + bupivacaine consumption were significantly lower in group M. Postoperative serum magnesium levels were significantly higher in group M, but were within the normal range.

Conclusions: Magnesium causes a reduction in postoperative pain in comparison to saline when administered intra-articularly after arthroscopic shoulder surgery, and has no serious side effects.

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Visual analogue scale (VAS) scores at rest in control (n=30) and magnesium (n=30) groups (mean ± SD). *P<0.05. Preop Preoperative; Postop Postoperative
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f1-prm-20-35: Visual analogue scale (VAS) scores at rest in control (n=30) and magnesium (n=30) groups (mean ± SD). *P<0.05. Preop Preoperative; Postop Postoperative

Mentions: Pain scores measured at rest 1 h, 2 h, 6 h, 8 h and 12 h after the end of surgery were significantly lower in group M than in group C (Figure 1). Furthermore, pain scores 1 h, 2 h, 6 h, 8 h and 12 h after the end of surgery during passive motion in group M were significantly lower than in group C (Figure 2).


Is intra-articular magnesium effective for postoperative analgesia in arthroscopic shoulder surgery?

Saritas TB, Borazan H, Okesli S, Yel M, Otelcioglu Ş - Pain Res Manag (2014)

Visual analogue scale (VAS) scores at rest in control (n=30) and magnesium (n=30) groups (mean ± SD). *P<0.05. Preop Preoperative; Postop Postoperative
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325888&req=5

f1-prm-20-35: Visual analogue scale (VAS) scores at rest in control (n=30) and magnesium (n=30) groups (mean ± SD). *P<0.05. Preop Preoperative; Postop Postoperative
Mentions: Pain scores measured at rest 1 h, 2 h, 6 h, 8 h and 12 h after the end of surgery were significantly lower in group M than in group C (Figure 1). Furthermore, pain scores 1 h, 2 h, 6 h, 8 h and 12 h after the end of surgery during passive motion in group M were significantly lower than in group C (Figure 2).

Bottom Line: The analgesic effect was estimated using a visual analogue scale 1 h, 2 h, 6 h, 8 h, 12 h, 18 h and 24 h after operation.Total diclofenac consumption and intra-articular morphine + bupivacaine consumption were significantly lower in group M.Postoperative serum magnesium levels were significantly higher in group M, but were within the normal range.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Various medications are used intra-articularly for postoperative pain reduction after arthroscopic shoulder surgery. Magnesium, a N-methyl-D-aspartate receptor antagonist, may be effective for reduction of both postoperative pain scores and analgesic requirements.

Methods: A total of 67 patients undergoing arthroscopic shoulder surgery were divided randomly into two groups to receive intra-articular injections of either 10 mL magnesium sulphate (100 mg⁄mL; group M, n=34) or 10 mL of normal saline (group C, n=33). The analgesic effect was estimated using a visual analogue scale 1 h, 2 h, 6 h, 8 h, 12 h, 18 h and 24 h after operation. Postoperative analgesia was maintained by intra-articular morphine (0.01%, 10 mg) + bupivacaine (0.5%, 100 mL) patient-controlled analgesia device as a 1 mL infusion with a 1 mL bolus dose and 15 min lock-out time; for visual analogue scale scores >5, intramuscular diclofenac sodium 75 mg was administered as needed during the study period (maximum two times).

Results: Intra-articular magnesium resulted in a significant reduction in pain scores in group M compared with group C 1 h, 2 h, 6 h, 8 h and 12 h after the end of surgery, respectively, at rest and with passive motion. Total diclofenac consumption and intra-articular morphine + bupivacaine consumption were significantly lower in group M. Postoperative serum magnesium levels were significantly higher in group M, but were within the normal range.

Conclusions: Magnesium causes a reduction in postoperative pain in comparison to saline when administered intra-articularly after arthroscopic shoulder surgery, and has no serious side effects.

Show MeSH
Related in: MedlinePlus