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Dynamic mechanical assessment of muscle hyperalgesia in humans: the dynamic algometer.

Finocchietti S, Graven-Nielsen T, Arendt-Nielsen L - Pain Res Manag (2015 Jan-Feb)

Bottom Line: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia.The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry.It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia. Consequently, new methods able to detect this distribution are needed.

Objective: To develop and test a new method for assessing muscle hyperalgesia with high temporal and spatial resolution that provides complementary information compared with information obtained by traditional static pressure algometry.

Methods: The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry. The device consisted of a wheel that was rolled over the muscle tissue with a fixed velocity and different predefined forces. The pain threshold force was determined and pain intensity to a fixed-force stimulation was continuously rated on a visual analogue scale while the wheel was rolling over the muscle. The pressure pain sensitivity was evaluated before, during, and after muscle pain and hyperalgesia induced unilaterally by either injection of hypertonic saline (0.5 mL, 6%) into the tibialis anterior or eccentric exercise evoking delayed-onset muscle soreness (DOMS).

Results: The intraclass correlation coefficient was >0.88 for the dynamic thresholds; thus, the method was reliable. Compared with baseline, both techniques detected hyperalgesia at the saline injection site and during DOMS (P<0.05). The dynamic algometer also detected the widespread, patchy distribution of sensitive loci during DOMS, which was difficult to evaluate using static pressure algometry.

Discussion and conclusion: The present study showed that dynamic pressure algometry is a reliable tool for evaluating muscle hyperalgesia (threshold and pain rating) with high temporal and spatial resolution. It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

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Related in: MedlinePlus

Mean visual analogue scale scores (cm) versus distance (cm) profile after saline-induced muscle hyperalgesia in the tibialis anterior muscle of the experimental muscle pain leg (A) and control leg (B). The rolling stimulation assessment on the lines A, B and C is illustrated with black lines. The grey line related to each curve indicates the SD
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f3-prm-20-29: Mean visual analogue scale scores (cm) versus distance (cm) profile after saline-induced muscle hyperalgesia in the tibialis anterior muscle of the experimental muscle pain leg (A) and control leg (B). The rolling stimulation assessment on the lines A, B and C is illustrated with black lines. The grey line related to each curve indicates the SD

Mentions: Before saline-induced pain, the VAS-distance area was, on average, 0.004±0.003 cm2 during rolling mechanical stimulation with an intensity equal to the DPT level. The peak VAS during rolling mechanical stimulation was 2.2±0.2 cm at a position corresponding to the injection site of hypertonic saline (Figure 3). ANOVA of the VAS-distance area demonstrated a significant interaction among pain paradigm, leg and line position (F4=9.1, P<0.01). Five minutes post-pain, the VAS-distance area corresponding to the line of the injection site on the right leg was significantly higher compared with the other two lines and with the other leg (NK: P<0.03).


Dynamic mechanical assessment of muscle hyperalgesia in humans: the dynamic algometer.

Finocchietti S, Graven-Nielsen T, Arendt-Nielsen L - Pain Res Manag (2015 Jan-Feb)

Mean visual analogue scale scores (cm) versus distance (cm) profile after saline-induced muscle hyperalgesia in the tibialis anterior muscle of the experimental muscle pain leg (A) and control leg (B). The rolling stimulation assessment on the lines A, B and C is illustrated with black lines. The grey line related to each curve indicates the SD
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325887&req=5

f3-prm-20-29: Mean visual analogue scale scores (cm) versus distance (cm) profile after saline-induced muscle hyperalgesia in the tibialis anterior muscle of the experimental muscle pain leg (A) and control leg (B). The rolling stimulation assessment on the lines A, B and C is illustrated with black lines. The grey line related to each curve indicates the SD
Mentions: Before saline-induced pain, the VAS-distance area was, on average, 0.004±0.003 cm2 during rolling mechanical stimulation with an intensity equal to the DPT level. The peak VAS during rolling mechanical stimulation was 2.2±0.2 cm at a position corresponding to the injection site of hypertonic saline (Figure 3). ANOVA of the VAS-distance area demonstrated a significant interaction among pain paradigm, leg and line position (F4=9.1, P<0.01). Five minutes post-pain, the VAS-distance area corresponding to the line of the injection site on the right leg was significantly higher compared with the other two lines and with the other leg (NK: P<0.03).

Bottom Line: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia.The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry.It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia. Consequently, new methods able to detect this distribution are needed.

Objective: To develop and test a new method for assessing muscle hyperalgesia with high temporal and spatial resolution that provides complementary information compared with information obtained by traditional static pressure algometry.

Methods: The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry. The device consisted of a wheel that was rolled over the muscle tissue with a fixed velocity and different predefined forces. The pain threshold force was determined and pain intensity to a fixed-force stimulation was continuously rated on a visual analogue scale while the wheel was rolling over the muscle. The pressure pain sensitivity was evaluated before, during, and after muscle pain and hyperalgesia induced unilaterally by either injection of hypertonic saline (0.5 mL, 6%) into the tibialis anterior or eccentric exercise evoking delayed-onset muscle soreness (DOMS).

Results: The intraclass correlation coefficient was >0.88 for the dynamic thresholds; thus, the method was reliable. Compared with baseline, both techniques detected hyperalgesia at the saline injection site and during DOMS (P<0.05). The dynamic algometer also detected the widespread, patchy distribution of sensitive loci during DOMS, which was difficult to evaluate using static pressure algometry.

Discussion and conclusion: The present study showed that dynamic pressure algometry is a reliable tool for evaluating muscle hyperalgesia (threshold and pain rating) with high temporal and spatial resolution. It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

Show MeSH
Related in: MedlinePlus