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Dynamic mechanical assessment of muscle hyperalgesia in humans: the dynamic algometer.

Finocchietti S, Graven-Nielsen T, Arendt-Nielsen L - Pain Res Manag (2015 Jan-Feb)

Bottom Line: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia.The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry.It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia. Consequently, new methods able to detect this distribution are needed.

Objective: To develop and test a new method for assessing muscle hyperalgesia with high temporal and spatial resolution that provides complementary information compared with information obtained by traditional static pressure algometry.

Methods: The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry. The device consisted of a wheel that was rolled over the muscle tissue with a fixed velocity and different predefined forces. The pain threshold force was determined and pain intensity to a fixed-force stimulation was continuously rated on a visual analogue scale while the wheel was rolling over the muscle. The pressure pain sensitivity was evaluated before, during, and after muscle pain and hyperalgesia induced unilaterally by either injection of hypertonic saline (0.5 mL, 6%) into the tibialis anterior or eccentric exercise evoking delayed-onset muscle soreness (DOMS).

Results: The intraclass correlation coefficient was >0.88 for the dynamic thresholds; thus, the method was reliable. Compared with baseline, both techniques detected hyperalgesia at the saline injection site and during DOMS (P<0.05). The dynamic algometer also detected the widespread, patchy distribution of sensitive loci during DOMS, which was difficult to evaluate using static pressure algometry.

Discussion and conclusion: The present study showed that dynamic pressure algometry is a reliable tool for evaluating muscle hyperalgesia (threshold and pain rating) with high temporal and spatial resolution. It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

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Related in: MedlinePlus

AThe dynamic pressure algometer. This device consists of a wheel that applies a specific force determined by a spring within the handle. The experimenter moves the algometer along the desired muscle at a constant velocity of 10 mm/s. An encoder is attached to the wheel and used to measure the distance (in cm) covered during the measurement, while the pain sensitivity is recorded by a electronic visual analogue scale.BMap of the sites for static pressure pain thresholds and dynamic pressure pain thresholds lines evaluated on the tibialis anterior muscle. The point of hypertonic saline injection is indicated in black
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f1-prm-20-29: AThe dynamic pressure algometer. This device consists of a wheel that applies a specific force determined by a spring within the handle. The experimenter moves the algometer along the desired muscle at a constant velocity of 10 mm/s. An encoder is attached to the wheel and used to measure the distance (in cm) covered during the measurement, while the pain sensitivity is recorded by a electronic visual analogue scale.BMap of the sites for static pressure pain thresholds and dynamic pressure pain thresholds lines evaluated on the tibialis anterior muscle. The point of hypertonic saline injection is indicated in black

Mentions: The dynamic pressure pain threshold (DPT) was assessed using the dynamic pressure algometer along three lines marked on the tibialis anterior muscle of both legs (Figure 1). The dynamic algometer consisted of a wheel through which the experimenter could apply eight different forces (450 g, 600 g, 800 g, 1300 g, 1500 g, 2100 g, 3400 g, 5000 g) controlled by springs. The wheel had a diameter of 35 mm and a width of 5 mm. The wheel movement was recorded via a digital encoder (Bournes, USA) with a sensitivity of 64 pulses/revolution to measure the distance covered during the rolling stimulation. The speed of the wheel was visually presented to the experimenter controlling the speed manually to approximately 10 mm/s.


Dynamic mechanical assessment of muscle hyperalgesia in humans: the dynamic algometer.

Finocchietti S, Graven-Nielsen T, Arendt-Nielsen L - Pain Res Manag (2015 Jan-Feb)

AThe dynamic pressure algometer. This device consists of a wheel that applies a specific force determined by a spring within the handle. The experimenter moves the algometer along the desired muscle at a constant velocity of 10 mm/s. An encoder is attached to the wheel and used to measure the distance (in cm) covered during the measurement, while the pain sensitivity is recorded by a electronic visual analogue scale.BMap of the sites for static pressure pain thresholds and dynamic pressure pain thresholds lines evaluated on the tibialis anterior muscle. The point of hypertonic saline injection is indicated in black
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325887&req=5

f1-prm-20-29: AThe dynamic pressure algometer. This device consists of a wheel that applies a specific force determined by a spring within the handle. The experimenter moves the algometer along the desired muscle at a constant velocity of 10 mm/s. An encoder is attached to the wheel and used to measure the distance (in cm) covered during the measurement, while the pain sensitivity is recorded by a electronic visual analogue scale.BMap of the sites for static pressure pain thresholds and dynamic pressure pain thresholds lines evaluated on the tibialis anterior muscle. The point of hypertonic saline injection is indicated in black
Mentions: The dynamic pressure pain threshold (DPT) was assessed using the dynamic pressure algometer along three lines marked on the tibialis anterior muscle of both legs (Figure 1). The dynamic algometer consisted of a wheel through which the experimenter could apply eight different forces (450 g, 600 g, 800 g, 1300 g, 1500 g, 2100 g, 3400 g, 5000 g) controlled by springs. The wheel had a diameter of 35 mm and a width of 5 mm. The wheel movement was recorded via a digital encoder (Bournes, USA) with a sensitivity of 64 pulses/revolution to measure the distance covered during the rolling stimulation. The speed of the wheel was visually presented to the experimenter controlling the speed manually to approximately 10 mm/s.

Bottom Line: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia.The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry.It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia. Consequently, new methods able to detect this distribution are needed.

Objective: To develop and test a new method for assessing muscle hyperalgesia with high temporal and spatial resolution that provides complementary information compared with information obtained by traditional static pressure algometry.

Methods: The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry. The device consisted of a wheel that was rolled over the muscle tissue with a fixed velocity and different predefined forces. The pain threshold force was determined and pain intensity to a fixed-force stimulation was continuously rated on a visual analogue scale while the wheel was rolling over the muscle. The pressure pain sensitivity was evaluated before, during, and after muscle pain and hyperalgesia induced unilaterally by either injection of hypertonic saline (0.5 mL, 6%) into the tibialis anterior or eccentric exercise evoking delayed-onset muscle soreness (DOMS).

Results: The intraclass correlation coefficient was >0.88 for the dynamic thresholds; thus, the method was reliable. Compared with baseline, both techniques detected hyperalgesia at the saline injection site and during DOMS (P<0.05). The dynamic algometer also detected the widespread, patchy distribution of sensitive loci during DOMS, which was difficult to evaluate using static pressure algometry.

Discussion and conclusion: The present study showed that dynamic pressure algometry is a reliable tool for evaluating muscle hyperalgesia (threshold and pain rating) with high temporal and spatial resolution. It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.

Show MeSH
Related in: MedlinePlus