Limits...
Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.

Meller J, Rogozin IB, Poliakov E, Meller N, Bedanov-Pack M, Plow EF, Qin J, Podrez EA, Byzova TV - Mol. Biol. Cell (2014)

Bottom Line: Among the analyzed species, all metazoan lineages—but none of the premetazoans—had at least one kindlin-encoding gene, whereas talin was present in several premetazoan lineages.The presence of this segment enables K2 but not K3 to localize to focal adhesions.Thus emergence and subsequent functional specialization of kindlins allowed multicellular organisms to develop additional tissue-specific adaptations of cell adhesiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.

Show MeSH

Related in: MedlinePlus

Maximum likelihood phylogenetic tree (JTT substitution model, the “all sites” option and the “gamma2 + invariant sites” option as implemented in the MEGA5 program). Some clades were collapsed using MEGA5 tree editor (the complete version of the tree is shown in Supplemental Figure S4). Numbers for interior branches refer to bootstrap values with 1000 pseudoreplicates. K, kindlin. The tree is rooted using the kindlin sequence from T. adhaerens.
© Copyright Policy - creative-commons
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4325847&req=5

Figure 3: Maximum likelihood phylogenetic tree (JTT substitution model, the “all sites” option and the “gamma2 + invariant sites” option as implemented in the MEGA5 program). Some clades were collapsed using MEGA5 tree editor (the complete version of the tree is shown in Supplemental Figure S4). Numbers for interior branches refer to bootstrap values with 1000 pseudoreplicates. K, kindlin. The tree is rooted using the kindlin sequence from T. adhaerens.

Mentions: A maximum-likelihood (ML) phylogenetic tree of the kindlin superfamily is shown in Figure 3 and Supplemental Figure S4. The ML tree is rooted using a kindlin sequence from T. adhaerens (Figure 3). In addition, neighbor-joining (NJ), minimum evolution (ME), and maximum parsimony (MP) trees are shown in Supplemental Figures S5–S7. The topologies of ML, NJ, MP, and ME trees are slightly different; however, these differences do not alter the results or the conclusions of the phylogenetic analysis presented.


Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.

Meller J, Rogozin IB, Poliakov E, Meller N, Bedanov-Pack M, Plow EF, Qin J, Podrez EA, Byzova TV - Mol. Biol. Cell (2014)

Maximum likelihood phylogenetic tree (JTT substitution model, the “all sites” option and the “gamma2 + invariant sites” option as implemented in the MEGA5 program). Some clades were collapsed using MEGA5 tree editor (the complete version of the tree is shown in Supplemental Figure S4). Numbers for interior branches refer to bootstrap values with 1000 pseudoreplicates. K, kindlin. The tree is rooted using the kindlin sequence from T. adhaerens.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325847&req=5

Figure 3: Maximum likelihood phylogenetic tree (JTT substitution model, the “all sites” option and the “gamma2 + invariant sites” option as implemented in the MEGA5 program). Some clades were collapsed using MEGA5 tree editor (the complete version of the tree is shown in Supplemental Figure S4). Numbers for interior branches refer to bootstrap values with 1000 pseudoreplicates. K, kindlin. The tree is rooted using the kindlin sequence from T. adhaerens.
Mentions: A maximum-likelihood (ML) phylogenetic tree of the kindlin superfamily is shown in Figure 3 and Supplemental Figure S4. The ML tree is rooted using a kindlin sequence from T. adhaerens (Figure 3). In addition, neighbor-joining (NJ), minimum evolution (ME), and maximum parsimony (MP) trees are shown in Supplemental Figures S5–S7. The topologies of ML, NJ, MP, and ME trees are slightly different; however, these differences do not alter the results or the conclusions of the phylogenetic analysis presented.

Bottom Line: Among the analyzed species, all metazoan lineages—but none of the premetazoans—had at least one kindlin-encoding gene, whereas talin was present in several premetazoan lineages.The presence of this segment enables K2 but not K3 to localize to focal adhesions.Thus emergence and subsequent functional specialization of kindlins allowed multicellular organisms to develop additional tissue-specific adaptations of cell adhesiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.

Show MeSH
Related in: MedlinePlus