Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.
Bottom Line: Kindlin appears to originate from a duplication of the sequence encoding the N-terminal fragment of talin (the talin head domain) with a subsequent insertion of the PH domain of separate origin.The presence of this segment enables K2 but not K3 to localize to focal adhesions.Thus emergence and subsequent functional specialization of kindlins allowed multicellular organisms to develop additional tissue-specific adaptations of cell adhesiveness.
Affiliation: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.Show MeSH
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Mentions: A maximum-likelihood (ML) phylogenetic tree of the kindlin superfamily is shown in Figure 3 and Supplemental Figure S4. The ML tree is rooted using a kindlin sequence from T. adhaerens (Figure 3). In addition, neighbor-joining (NJ), minimum evolution (ME), and maximum parsimony (MP) trees are shown in Supplemental Figures S5–S7. The topologies of ML, NJ, MP, and ME trees are slightly different; however, these differences do not alter the results or the conclusions of the phylogenetic analysis presented.
Affiliation: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.