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Ex vivo lung perfusion - state of the art in lung donor pool expansion.

Popov AF, Sabashnikov A, Patil NP, Zeriouh M, Mohite PN, Zych B, Saez DG, Schmack B, Ruhparwar A, Dohmen PM, Karck M, Simon AR, Weymann A - Med Sci Monit Basic Res (2015)

Bottom Line: Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs.This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application.The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.

ABSTRACT
Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment techniques could contribute to improved function in previously rejected lungs. Ex vivo lung perfusion (EVLP) already demonstrated its value in identification of transplantable grafts from the higher risk donor pool. Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs. This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application. The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs.

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Related in: MedlinePlus

EVLP dome for lung assessment (Vitrolife, Göteborg, Sweden).
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Related In: Results  -  Collection


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f3-medscimonitbasicres-21-9: EVLP dome for lung assessment (Vitrolife, Göteborg, Sweden).

Mentions: Once the lungs are at the recipient center, sterile dissection of the main pulmonary artery and trachea is performed with a long left atrial cuff. The left atrial cuff is trimmed appropriately and anastomosed with 4-0 polypropylene to a cannula with an integrated transducer tool for pressure monitoring (Figure 1). Afterwards, the main pulmonary artery is cannulated with a customized cannula and an endotracheal tube (size 8) inserted into the trachea and secured with 2 heavy silk ties (Figure 2). After this important step, the inflated lungs are carefully transferred into the EVLP dome (Vitrolife, Gothenburg, Sweden) to provide humidity and temperature (Figure 3).


Ex vivo lung perfusion - state of the art in lung donor pool expansion.

Popov AF, Sabashnikov A, Patil NP, Zeriouh M, Mohite PN, Zych B, Saez DG, Schmack B, Ruhparwar A, Dohmen PM, Karck M, Simon AR, Weymann A - Med Sci Monit Basic Res (2015)

EVLP dome for lung assessment (Vitrolife, Göteborg, Sweden).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325829&req=5

f3-medscimonitbasicres-21-9: EVLP dome for lung assessment (Vitrolife, Göteborg, Sweden).
Mentions: Once the lungs are at the recipient center, sterile dissection of the main pulmonary artery and trachea is performed with a long left atrial cuff. The left atrial cuff is trimmed appropriately and anastomosed with 4-0 polypropylene to a cannula with an integrated transducer tool for pressure monitoring (Figure 1). Afterwards, the main pulmonary artery is cannulated with a customized cannula and an endotracheal tube (size 8) inserted into the trachea and secured with 2 heavy silk ties (Figure 2). After this important step, the inflated lungs are carefully transferred into the EVLP dome (Vitrolife, Gothenburg, Sweden) to provide humidity and temperature (Figure 3).

Bottom Line: Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs.This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application.The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.

ABSTRACT
Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment techniques could contribute to improved function in previously rejected lungs. Ex vivo lung perfusion (EVLP) already demonstrated its value in identification of transplantable grafts from the higher risk donor pool. Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs. This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application. The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs.

Show MeSH
Related in: MedlinePlus