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Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis.

Xie A, Zhang W, Chen M, Wang Y, Wang Y, Zhou Q, Zhu X - Med. Sci. Monit. (2015)

Bottom Line: Binary logistic regression was used to identify factors associated with HCA and neonatal outcomes.Gestational age at delivery and birth weight were significantly lower in HCA patients than control patients.The rate of 1-min Apgar score <7, abnormal neonatal intracranial ultrasound findings, neonatal pneumonia, bronchopulmonary dysplasia, early-onset neonatal sepsis, and mortality were higher in HCA patients, but no significant difference was observed in the incidence of neonatal respiratory distress syndrome, necrotizing enterocolitis, hyperbilirubinemia, or hypoglycemia.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).

ABSTRACT

Background: The aim of this study was to identify factors predicting histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM).

Material and methods: We retrospectively enrolled 371 women diagnosed with PPROM at less than 34 weeks of gestation at the Second Affiliated Hospital of Wenzhou Medical University between January 2008 and December 2012. HCA was diagnosed by placental histopathology in 70% of participants. Binary logistic regression was used to identify factors associated with HCA and neonatal outcomes.

Results: Patient age, rate of parity, tocolysis, cesarean section, serum C reactive protein (CRP) level at admission, white blood cell count, and latency duration did not significantly differ between the 2 groups. Binary logistic regression revealed that oligohydramnios at admission, gestational age at PPROM, and serum CRP >8 mg/L before delivery were significantly associated with HCA. Gestational age at delivery and birth weight were significantly lower in HCA patients than control patients. The rate of 1-min Apgar score <7, abnormal neonatal intracranial ultrasound findings, neonatal pneumonia, bronchopulmonary dysplasia, early-onset neonatal sepsis, and mortality were higher in HCA patients, but no significant difference was observed in the incidence of neonatal respiratory distress syndrome, necrotizing enterocolitis, hyperbilirubinemia, or hypoglycemia.

Conclusions: Younger gestational age at time of PPROM, higher CRP level before delivery, and oligohydramnios at admission in women with PPROM are associated with HCA, and HCA is associated with some adverse neonatal outcomes.

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Incidence of HCA after PPROM at various gestational ages.
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f1-medscimonit-21-390: Incidence of HCA after PPROM at various gestational ages.

Mentions: Seventy percent (261/371) of participants with PPROM were diagnosed with HCA. The mean gestational age at PROM was 31.1±1.6 weeks, and the incidence of HCA increased significantly with decreasing gestational age (Figure 1). Mean gestational age at time of PPROM was significantly lower in the HCA group (30.9±1.6 weeks) than the control group (31.7±1.3 weeks) (Table 1).


Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis.

Xie A, Zhang W, Chen M, Wang Y, Wang Y, Zhou Q, Zhu X - Med. Sci. Monit. (2015)

Incidence of HCA after PPROM at various gestational ages.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325828&req=5

f1-medscimonit-21-390: Incidence of HCA after PPROM at various gestational ages.
Mentions: Seventy percent (261/371) of participants with PPROM were diagnosed with HCA. The mean gestational age at PROM was 31.1±1.6 weeks, and the incidence of HCA increased significantly with decreasing gestational age (Figure 1). Mean gestational age at time of PPROM was significantly lower in the HCA group (30.9±1.6 weeks) than the control group (31.7±1.3 weeks) (Table 1).

Bottom Line: Binary logistic regression was used to identify factors associated with HCA and neonatal outcomes.Gestational age at delivery and birth weight were significantly lower in HCA patients than control patients.The rate of 1-min Apgar score <7, abnormal neonatal intracranial ultrasound findings, neonatal pneumonia, bronchopulmonary dysplasia, early-onset neonatal sepsis, and mortality were higher in HCA patients, but no significant difference was observed in the incidence of neonatal respiratory distress syndrome, necrotizing enterocolitis, hyperbilirubinemia, or hypoglycemia.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).

ABSTRACT

Background: The aim of this study was to identify factors predicting histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM).

Material and methods: We retrospectively enrolled 371 women diagnosed with PPROM at less than 34 weeks of gestation at the Second Affiliated Hospital of Wenzhou Medical University between January 2008 and December 2012. HCA was diagnosed by placental histopathology in 70% of participants. Binary logistic regression was used to identify factors associated with HCA and neonatal outcomes.

Results: Patient age, rate of parity, tocolysis, cesarean section, serum C reactive protein (CRP) level at admission, white blood cell count, and latency duration did not significantly differ between the 2 groups. Binary logistic regression revealed that oligohydramnios at admission, gestational age at PPROM, and serum CRP >8 mg/L before delivery were significantly associated with HCA. Gestational age at delivery and birth weight were significantly lower in HCA patients than control patients. The rate of 1-min Apgar score <7, abnormal neonatal intracranial ultrasound findings, neonatal pneumonia, bronchopulmonary dysplasia, early-onset neonatal sepsis, and mortality were higher in HCA patients, but no significant difference was observed in the incidence of neonatal respiratory distress syndrome, necrotizing enterocolitis, hyperbilirubinemia, or hypoglycemia.

Conclusions: Younger gestational age at time of PPROM, higher CRP level before delivery, and oligohydramnios at admission in women with PPROM are associated with HCA, and HCA is associated with some adverse neonatal outcomes.

Show MeSH
Related in: MedlinePlus