The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.
Bottom Line: The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear.We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population.MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (P = 0.04).
Affiliation: Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, Kilifi, Kenya firstname.lastname@example.org.Show MeSH
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Mentions: All msp3 and msp6 SNPs analyzed were in linkage disequilibrium, representing two previously defined alleles, K1 and 3D7 (Fig. 1A and B, respectively) (16, 17), therefore precluding individual SNP analysis. The activity of all the drugs tested did not differ in parasites harboring 3D7 or K1 alleles in the msp3 and msp6 genes (Table 1). The SNPs of Pfmspdbl1 and Pfmspdbl2 were used to determine the actual loci within the haplotypes associated with changes in drug responses.
Affiliation: Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, Kilifi, Kenya email@example.com.