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Dermatoscopic findings of atrophic dermatofibrosarcoma protuberans.

Akay BN, Unlu E, Erdem C, Heper AO - Dermatol Pract Concept (2015)

Bottom Line: Dermatofibrosarcoma protuberans (DFSP) is an uncommon locally aggressive mesenchymal tumor with a high local recurrence rate.We report on a 23-year-old female, who presented with an atrophic, asymptomatic macule on the right side of her back 2 cm in diameter.Dermatoscopic examination revealed homogenous pigment network on a purplish erythematous background.

View Article: PubMed Central - PubMed

Affiliation: Ankara University Faculty of Medicine, Department of Dermatology, Ankara, Turkey.

ABSTRACT
Dermatofibrosarcoma protuberans (DFSP) is an uncommon locally aggressive mesenchymal tumor with a high local recurrence rate. Atrophic DFSP is a rare variant of DFSP characterized by a non-protuberant lesion. We report on a 23-year-old female, who presented with an atrophic, asymptomatic macule on the right side of her back 2 cm in diameter. Dermatoscopic examination revealed homogenous pigment network on a purplish erythematous background. The histopathological finding of the incisional biopsy material was consistent with DFSP. To our knowledge, this is the second case of atrophic DFSP discussing the dermatoscopic features of this relatively rare condition.

No MeSH data available.


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(A) Positive immunhistochemically staining for CD34 (X200); (B) negative immunhistochemically staining for factor XIIIa (X200). (Copyright: ©2015 Akay et al.)
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f3-dp0501a12: (A) Positive immunhistochemically staining for CD34 (X200); (B) negative immunhistochemically staining for factor XIIIa (X200). (Copyright: ©2015 Akay et al.)

Mentions: A 23-year-old female presented with an asymptomatic, erythematous, atrophic macule on the upper right side of her back that increased gradually in size within the last four years without any symptoms (Figure 1A). On physical examination the surface of the lesion was smooth and no induration was examined on palpation. There was no history of trauma. Dermatoscopic evaluation of the lesion using 3Gen DermLite-II Pro HR and documented with DermLite-Foto 3Gen (LLC, Dana Point, CA, USA) showed a homogenous pigment network on a purplish erythematous background (Figure 1B). A skin biopsy was taken with the preliminary diagnosis of morphea and cutaneous mastocytosis. Histopathological examination of H&E (hematoxylin and eosin) stained sections revealed epidermal atrophy, increase in melanin in basal keratinocytes and heavy dermal cellular infiltrate composed of spindle-shaped cells arranged in a storiform pattern that extended into the subcutaneous tissue (Figure 2). Immunhistochemical staining for CD34 was positive, while factor XIIIa was negative (Figure 3A, B). The diagnosis of dermatofibrosarcoma protuberans (DFSP) was made according to these findings. The patient was referred to Department of Plastic and Reconstructive Surgery for total excision. Excision was made with 3 cm safe surgical margins. No recurrence has been observed for one year.


Dermatoscopic findings of atrophic dermatofibrosarcoma protuberans.

Akay BN, Unlu E, Erdem C, Heper AO - Dermatol Pract Concept (2015)

(A) Positive immunhistochemically staining for CD34 (X200); (B) negative immunhistochemically staining for factor XIIIa (X200). (Copyright: ©2015 Akay et al.)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325695&req=5

f3-dp0501a12: (A) Positive immunhistochemically staining for CD34 (X200); (B) negative immunhistochemically staining for factor XIIIa (X200). (Copyright: ©2015 Akay et al.)
Mentions: A 23-year-old female presented with an asymptomatic, erythematous, atrophic macule on the upper right side of her back that increased gradually in size within the last four years without any symptoms (Figure 1A). On physical examination the surface of the lesion was smooth and no induration was examined on palpation. There was no history of trauma. Dermatoscopic evaluation of the lesion using 3Gen DermLite-II Pro HR and documented with DermLite-Foto 3Gen (LLC, Dana Point, CA, USA) showed a homogenous pigment network on a purplish erythematous background (Figure 1B). A skin biopsy was taken with the preliminary diagnosis of morphea and cutaneous mastocytosis. Histopathological examination of H&E (hematoxylin and eosin) stained sections revealed epidermal atrophy, increase in melanin in basal keratinocytes and heavy dermal cellular infiltrate composed of spindle-shaped cells arranged in a storiform pattern that extended into the subcutaneous tissue (Figure 2). Immunhistochemical staining for CD34 was positive, while factor XIIIa was negative (Figure 3A, B). The diagnosis of dermatofibrosarcoma protuberans (DFSP) was made according to these findings. The patient was referred to Department of Plastic and Reconstructive Surgery for total excision. Excision was made with 3 cm safe surgical margins. No recurrence has been observed for one year.

Bottom Line: Dermatofibrosarcoma protuberans (DFSP) is an uncommon locally aggressive mesenchymal tumor with a high local recurrence rate.We report on a 23-year-old female, who presented with an atrophic, asymptomatic macule on the right side of her back 2 cm in diameter.Dermatoscopic examination revealed homogenous pigment network on a purplish erythematous background.

View Article: PubMed Central - PubMed

Affiliation: Ankara University Faculty of Medicine, Department of Dermatology, Ankara, Turkey.

ABSTRACT
Dermatofibrosarcoma protuberans (DFSP) is an uncommon locally aggressive mesenchymal tumor with a high local recurrence rate. Atrophic DFSP is a rare variant of DFSP characterized by a non-protuberant lesion. We report on a 23-year-old female, who presented with an atrophic, asymptomatic macule on the right side of her back 2 cm in diameter. Dermatoscopic examination revealed homogenous pigment network on a purplish erythematous background. The histopathological finding of the incisional biopsy material was consistent with DFSP. To our knowledge, this is the second case of atrophic DFSP discussing the dermatoscopic features of this relatively rare condition.

No MeSH data available.


Related in: MedlinePlus