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Incidental Merkel cell carcinoma in a cutaneous horn: a case report.

Schick BA, Tobe JS, Joseph MG, Rouse TB, Gabril MY - Dermatol Pract Concept (2015)

Bottom Line: Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin.We present a 93-year-old female who presented with a "cutaneous horn" on the face.This case report highlights the significant association between MCC and squamous cell carcinoma and the uncommon clinical presentation of this combined tumor in the form of a cutaneous horn.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, London Health Sciences Centre and Western University, London, Ontario, Canada.

ABSTRACT
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a "cutaneous horn" on the face. On excision, histologic examination revealed a combined squamous cell carcinoma in situ with underlying MCC. Merkel cell polyomavirus immunohistochemistry was negative in this lesion. This case report highlights the significant association between MCC and squamous cell carcinoma and the uncommon clinical presentation of this combined tumor in the form of a cutaneous horn.

No MeSH data available.


Related in: MedlinePlus

(A & B) Higher magnification shows two lesions: a SCC-IS and underlying MCC located in the dermis. H&E. (Copyright: ©2015 Schick et al.)
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f2a-dp0501a08: (A & B) Higher magnification shows two lesions: a SCC-IS and underlying MCC located in the dermis. H&E. (Copyright: ©2015 Schick et al.)

Mentions: Histologic examination of the cutaneous horn showed a SCC-IS with marked hyperkeratosis, acanthosis and full thickness atypia of the squamous epithelium (Figures 1, 2A, 2B). There was an underlying dermal MCC with an infiltrative growth pattern, composed of a monotonous population of malignant small cells with hyperchromatic nuclei, scant cytoplasm, frequent mitoses (14/mm2) and apoptotic bodies (Figure 2C). The estimated MCC tumor thickness was 1.6 cm. The closest deep margin was 1.5 mm, the closest peripheral margin was 8.0 mm, and there was no lymphovascular invasion.


Incidental Merkel cell carcinoma in a cutaneous horn: a case report.

Schick BA, Tobe JS, Joseph MG, Rouse TB, Gabril MY - Dermatol Pract Concept (2015)

(A & B) Higher magnification shows two lesions: a SCC-IS and underlying MCC located in the dermis. H&E. (Copyright: ©2015 Schick et al.)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325691&req=5

f2a-dp0501a08: (A & B) Higher magnification shows two lesions: a SCC-IS and underlying MCC located in the dermis. H&E. (Copyright: ©2015 Schick et al.)
Mentions: Histologic examination of the cutaneous horn showed a SCC-IS with marked hyperkeratosis, acanthosis and full thickness atypia of the squamous epithelium (Figures 1, 2A, 2B). There was an underlying dermal MCC with an infiltrative growth pattern, composed of a monotonous population of malignant small cells with hyperchromatic nuclei, scant cytoplasm, frequent mitoses (14/mm2) and apoptotic bodies (Figure 2C). The estimated MCC tumor thickness was 1.6 cm. The closest deep margin was 1.5 mm, the closest peripheral margin was 8.0 mm, and there was no lymphovascular invasion.

Bottom Line: Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin.We present a 93-year-old female who presented with a "cutaneous horn" on the face.This case report highlights the significant association between MCC and squamous cell carcinoma and the uncommon clinical presentation of this combined tumor in the form of a cutaneous horn.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, London Health Sciences Centre and Western University, London, Ontario, Canada.

ABSTRACT
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a "cutaneous horn" on the face. On excision, histologic examination revealed a combined squamous cell carcinoma in situ with underlying MCC. Merkel cell polyomavirus immunohistochemistry was negative in this lesion. This case report highlights the significant association between MCC and squamous cell carcinoma and the uncommon clinical presentation of this combined tumor in the form of a cutaneous horn.

No MeSH data available.


Related in: MedlinePlus