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Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update.

Ferrara G, Cavicchini S, Corradin MT - Dermatol Pract Concept (2015)

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Anatomic Pathology Unit, Gaetano Rummo Hospital, Benevento, Italy.

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During the following forty years, however, the entity described by Sophie Spitz was thought to be completely benign, with metastasizing cases being intuitively considered as cases of melanomas simulating Spitz nevus (Spitzoid melanoma)... We have already pointed out that dermoscopy seems to allow clinicians to increasingly identify and excise pigmented spindle cell Spitz nevus and Reed nevus (which are basically the same clinicopathological entity), to such an extent that the brown-black plaque-like “variant” is surprisingly becoming the most common (and therefore “typical”) Spitz nevus encountered in clinico-dermoscopic-pathologic studies... The present paper will focus on the clinicopathological features of papulonodular hypopigmented Spitzoid lesions, which are “atypical” with a much greater frequency than their plaque-like heavily pigmented counterpart... According to this view, the adjective “atypical” is redundant and useless, because any Spitz nevus is “atypical” by definition; nevertheless, it can be differentiated from its malignant simulator (i.e., Spitzoid melanoma) according to a well defined set of histologic criteria; every Spitzoid (and non-Spitzoid) melanocytic proliferation behaves as either a benign or a malignant neoplasm which we can be unable to correctly categorize simply because our brain can fail to correctly apply the diagnostic criteria... The first problem is purely morphologic: by assuming that Spitz nevus is a simulator of melanoma (Spitz nevus as a pseudomalignancy) and that melanoma resembling Spitz nevus is a simulator of its simulator (Spitzoid melanoma as a pseudo-pseudomalignancy), it is not surprising that the diagnosis of such lesions is a quandary even among experts who may be indeed unable to place an “I don’t know” lesion into a either “nevus” or “melanoma” category... The following sections will focus on hypopigmented Spitzoid lesions; nevertheless, the above-specified algorithm must be implemented for all Spitzoid lesions, irrespective of the amount of their pigmentation... A hypopigmented Spitzoid melanocytic neoplasm can be typified by at least one of the following:Homogeneous pink color: sometimes associated with a brownish hue or remnant(s) of brown pigmentation... In our experience, a diagnosis of Spitz nevus in the presence of a polymorphous vascular pattern must be made only under a compelling histopathological evidence of benignity; we have also suggested that when a given Spitzoid lesion is histopathologically atypical but its “grading” is uncertain, the presence of a highly atypical vascular pattern could point toward its management as a “tumor” instead of an “atypical nevus”... On the excision specimen, the “shoulder” of the neoplasm disclosed a bland morphology, featuring monomorphic spindle cells, probably representing a benign background (Spitz nevus) in which Spitzoid melanoma had been developing... The prognosis of Spitz tumors is age-dependent... Adult patients, who are expected to be at greater risk, could be managed more aggressively... The suggested management for both pediatric-type and adult-type Spitzoid melanoma is obviously the same as for “conventional” melanoma... The introduction of dermoscopy has significantly changed the clinical diorama of Spitzoid lesions... Since there are still many controversial points in the histopathologic categorization of these lesions, clinicopathologic correlation must be the mainstay for their diagnosis and proper management.

No MeSH data available.


Related in: MedlinePlus

A lesion of the right thigh in a 22-year-old woman. The lesion is clinically (A, inset) reddish and sharply circumscribed; on dermoscopy (A) its main feature is reticular depigmentation, which is associated with regularly distributed light brown dots/globules. Overall, the lesion is very symmetric. Nevertheless, it is slightly atypical histopathologically. The silhouette is dome-shaped, with a sharp lateral circumscription (B) but also with a central exaggerated confluence of nests within the superficial dermis (C) at this level, cytomorphology is very bland and monomorphic, with no mitotic figure (D). Histopathological diagnosis: Spitz nevus according to Ackerman’s classification [8]; Spitz tumor with atypical features according to Barnhill’s classification, 2006 [19]. Our histopathological diagnosis was atypical compound Spitz nevus and a narrow re-excision was advised. (Copyright: ©2015 Ferrara et al.)
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f1-dp0501a06: A lesion of the right thigh in a 22-year-old woman. The lesion is clinically (A, inset) reddish and sharply circumscribed; on dermoscopy (A) its main feature is reticular depigmentation, which is associated with regularly distributed light brown dots/globules. Overall, the lesion is very symmetric. Nevertheless, it is slightly atypical histopathologically. The silhouette is dome-shaped, with a sharp lateral circumscription (B) but also with a central exaggerated confluence of nests within the superficial dermis (C) at this level, cytomorphology is very bland and monomorphic, with no mitotic figure (D). Histopathological diagnosis: Spitz nevus according to Ackerman’s classification [8]; Spitz tumor with atypical features according to Barnhill’s classification, 2006 [19]. Our histopathological diagnosis was atypical compound Spitz nevus and a narrow re-excision was advised. (Copyright: ©2015 Ferrara et al.)

Mentions: Any single above-listed feature can be seen also in melanoma. Symmetric and plaque-like or slightly raised (dome-shaped) cutaneous lesions showing these dermoscopic features in a tidy fashion are most commonly Spitz nevi; nevertheless, a histopathologically atypical Spitzoid proliferation can be dermoscopically quite tidy and symmetric (Figure 1), thereby underlining once again the need to excise all lesions with Spitzoid features after puberty.


Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update.

Ferrara G, Cavicchini S, Corradin MT - Dermatol Pract Concept (2015)

A lesion of the right thigh in a 22-year-old woman. The lesion is clinically (A, inset) reddish and sharply circumscribed; on dermoscopy (A) its main feature is reticular depigmentation, which is associated with regularly distributed light brown dots/globules. Overall, the lesion is very symmetric. Nevertheless, it is slightly atypical histopathologically. The silhouette is dome-shaped, with a sharp lateral circumscription (B) but also with a central exaggerated confluence of nests within the superficial dermis (C) at this level, cytomorphology is very bland and monomorphic, with no mitotic figure (D). Histopathological diagnosis: Spitz nevus according to Ackerman’s classification [8]; Spitz tumor with atypical features according to Barnhill’s classification, 2006 [19]. Our histopathological diagnosis was atypical compound Spitz nevus and a narrow re-excision was advised. (Copyright: ©2015 Ferrara et al.)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325689&req=5

f1-dp0501a06: A lesion of the right thigh in a 22-year-old woman. The lesion is clinically (A, inset) reddish and sharply circumscribed; on dermoscopy (A) its main feature is reticular depigmentation, which is associated with regularly distributed light brown dots/globules. Overall, the lesion is very symmetric. Nevertheless, it is slightly atypical histopathologically. The silhouette is dome-shaped, with a sharp lateral circumscription (B) but also with a central exaggerated confluence of nests within the superficial dermis (C) at this level, cytomorphology is very bland and monomorphic, with no mitotic figure (D). Histopathological diagnosis: Spitz nevus according to Ackerman’s classification [8]; Spitz tumor with atypical features according to Barnhill’s classification, 2006 [19]. Our histopathological diagnosis was atypical compound Spitz nevus and a narrow re-excision was advised. (Copyright: ©2015 Ferrara et al.)
Mentions: Any single above-listed feature can be seen also in melanoma. Symmetric and plaque-like or slightly raised (dome-shaped) cutaneous lesions showing these dermoscopic features in a tidy fashion are most commonly Spitz nevi; nevertheless, a histopathologically atypical Spitzoid proliferation can be dermoscopically quite tidy and symmetric (Figure 1), thereby underlining once again the need to excise all lesions with Spitzoid features after puberty.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Anatomic Pathology Unit, Gaetano Rummo Hospital, Benevento, Italy.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

During the following forty years, however, the entity described by Sophie Spitz was thought to be completely benign, with metastasizing cases being intuitively considered as cases of melanomas simulating Spitz nevus (Spitzoid melanoma)... We have already pointed out that dermoscopy seems to allow clinicians to increasingly identify and excise pigmented spindle cell Spitz nevus and Reed nevus (which are basically the same clinicopathological entity), to such an extent that the brown-black plaque-like “variant” is surprisingly becoming the most common (and therefore “typical”) Spitz nevus encountered in clinico-dermoscopic-pathologic studies... The present paper will focus on the clinicopathological features of papulonodular hypopigmented Spitzoid lesions, which are “atypical” with a much greater frequency than their plaque-like heavily pigmented counterpart... According to this view, the adjective “atypical” is redundant and useless, because any Spitz nevus is “atypical” by definition; nevertheless, it can be differentiated from its malignant simulator (i.e., Spitzoid melanoma) according to a well defined set of histologic criteria; every Spitzoid (and non-Spitzoid) melanocytic proliferation behaves as either a benign or a malignant neoplasm which we can be unable to correctly categorize simply because our brain can fail to correctly apply the diagnostic criteria... The first problem is purely morphologic: by assuming that Spitz nevus is a simulator of melanoma (Spitz nevus as a pseudomalignancy) and that melanoma resembling Spitz nevus is a simulator of its simulator (Spitzoid melanoma as a pseudo-pseudomalignancy), it is not surprising that the diagnosis of such lesions is a quandary even among experts who may be indeed unable to place an “I don’t know” lesion into a either “nevus” or “melanoma” category... The following sections will focus on hypopigmented Spitzoid lesions; nevertheless, the above-specified algorithm must be implemented for all Spitzoid lesions, irrespective of the amount of their pigmentation... A hypopigmented Spitzoid melanocytic neoplasm can be typified by at least one of the following:Homogeneous pink color: sometimes associated with a brownish hue or remnant(s) of brown pigmentation... In our experience, a diagnosis of Spitz nevus in the presence of a polymorphous vascular pattern must be made only under a compelling histopathological evidence of benignity; we have also suggested that when a given Spitzoid lesion is histopathologically atypical but its “grading” is uncertain, the presence of a highly atypical vascular pattern could point toward its management as a “tumor” instead of an “atypical nevus”... On the excision specimen, the “shoulder” of the neoplasm disclosed a bland morphology, featuring monomorphic spindle cells, probably representing a benign background (Spitz nevus) in which Spitzoid melanoma had been developing... The prognosis of Spitz tumors is age-dependent... Adult patients, who are expected to be at greater risk, could be managed more aggressively... The suggested management for both pediatric-type and adult-type Spitzoid melanoma is obviously the same as for “conventional” melanoma... The introduction of dermoscopy has significantly changed the clinical diorama of Spitzoid lesions... Since there are still many controversial points in the histopathologic categorization of these lesions, clinicopathologic correlation must be the mainstay for their diagnosis and proper management.

No MeSH data available.


Related in: MedlinePlus