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Melanoma in situ colonizing basal cell carcinoma: a case report and review of the literature.

Mancebo SE, Marchetti MA, Hollmann TJ, Marghoob AA, Busam KJ, Halpern AC - Dermatol Pract Concept (2015)

Bottom Line: We describe a bluish nodule on the left forearm found during routine skin cancer surveillance examination with suspicious dermatoscopic findings including central-blue-white veil, sparse atypical dots, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation at the periphery.Histopathology demonstrated a pigmented BCC with an overlying and adjacent melanoma in situ (MIS), as well as colonization of the BCC nodule by melanoma cells.The prognostic and management challenges inherent to this distinctive neoplasm are summarized.

View Article: PubMed Central - PubMed

Affiliation: Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

ABSTRACT
Colonization of basal cell carcinoma (BCC) by melanoma cells is a unique and uncommonly reported cutaneous entity. We describe a bluish nodule on the left forearm found during routine skin cancer surveillance examination with suspicious dermatoscopic findings including central-blue-white veil, sparse atypical dots, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation at the periphery. Histopathology demonstrated a pigmented BCC with an overlying and adjacent melanoma in situ (MIS), as well as colonization of the BCC nodule by melanoma cells. We performed a review of the literature on the topic and discuss other presentations of cutaneous neoplasms composed of both BCC and melanoma, including collision, combined, and biphenotypic tumors. The prognostic and management challenges inherent to this distinctive neoplasm are summarized.

No MeSH data available.


Related in: MedlinePlus

Nonpolarized contact dermoscopic image showing central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with irregular tan-brown pigmentation. (Copyright: ©2015 Mancebo et al.)
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f2-dp0501a04: Nonpolarized contact dermoscopic image showing central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with irregular tan-brown pigmentation. (Copyright: ©2015 Mancebo et al.)

Mentions: A man in his eighties with a past medical history notable for 4 primary cutaneous melanomas (all AJCC Stage IA or 0), squamous cell skin cancer, and severe actinic damage presented for routine skin cancer surveillance follow-up. On the left dorsal forearm, a new 8 mm bluish nodule was detected during photographically assisted examination using total body photography digital images (Figure 1). The patient was unaware of the lesion and denied the presence of any symptoms, including pain, itching, or bleeding. Non-polarized contact dermatoscopic examination revealed a central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation (Figure 2). No lymph-adenopathy was present in the bilateral epitrochlear, axillary, supraclavicular, or cervical nodal basins, and there were no systemic symptoms.


Melanoma in situ colonizing basal cell carcinoma: a case report and review of the literature.

Mancebo SE, Marchetti MA, Hollmann TJ, Marghoob AA, Busam KJ, Halpern AC - Dermatol Pract Concept (2015)

Nonpolarized contact dermoscopic image showing central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with irregular tan-brown pigmentation. (Copyright: ©2015 Mancebo et al.)
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4325687&req=5

f2-dp0501a04: Nonpolarized contact dermoscopic image showing central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with irregular tan-brown pigmentation. (Copyright: ©2015 Mancebo et al.)
Mentions: A man in his eighties with a past medical history notable for 4 primary cutaneous melanomas (all AJCC Stage IA or 0), squamous cell skin cancer, and severe actinic damage presented for routine skin cancer surveillance follow-up. On the left dorsal forearm, a new 8 mm bluish nodule was detected during photographically assisted examination using total body photography digital images (Figure 1). The patient was unaware of the lesion and denied the presence of any symptoms, including pain, itching, or bleeding. Non-polarized contact dermatoscopic examination revealed a central blue-white veil, scale, sparse atypical blue and black dots focally at the periphery, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation (Figure 2). No lymph-adenopathy was present in the bilateral epitrochlear, axillary, supraclavicular, or cervical nodal basins, and there were no systemic symptoms.

Bottom Line: We describe a bluish nodule on the left forearm found during routine skin cancer surveillance examination with suspicious dermatoscopic findings including central-blue-white veil, sparse atypical dots, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation at the periphery.Histopathology demonstrated a pigmented BCC with an overlying and adjacent melanoma in situ (MIS), as well as colonization of the BCC nodule by melanoma cells.The prognostic and management challenges inherent to this distinctive neoplasm are summarized.

View Article: PubMed Central - PubMed

Affiliation: Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

ABSTRACT
Colonization of basal cell carcinoma (BCC) by melanoma cells is a unique and uncommonly reported cutaneous entity. We describe a bluish nodule on the left forearm found during routine skin cancer surveillance examination with suspicious dermatoscopic findings including central-blue-white veil, sparse atypical dots, and a surrounding pink vascular blush with focal irregular tan-brown pigmentation at the periphery. Histopathology demonstrated a pigmented BCC with an overlying and adjacent melanoma in situ (MIS), as well as colonization of the BCC nodule by melanoma cells. We performed a review of the literature on the topic and discuss other presentations of cutaneous neoplasms composed of both BCC and melanoma, including collision, combined, and biphenotypic tumors. The prognostic and management challenges inherent to this distinctive neoplasm are summarized.

No MeSH data available.


Related in: MedlinePlus