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Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature.

Rupley KA, Riahi RR, Hooper DO - Dermatol Pract Concept (2015)

Bottom Line: GA and NL are characterized histologically by areas of necrobiosis of collagen.We report on a 67-year-old Caucasian woman with a history of NL on the anterior shins that later developed lesions of GA on the breasts, trunk, and wrist.We also review the literature and discuss the characteristics of patients with concomitant GA and NL.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.

ABSTRACT
Granuloma annulare (GA) and necrobiosis lipoidica (NL) are granulomatous diseases of undetermined etiology. Rarely, both dermatoses have been reported to occur concomitantly in patients. GA and NL are characterized histologically by areas of necrobiosis of collagen. The two diseases share some common characteristics, which may suggest that these dermatoses could occur as a spectrum in some patients or possibly share a similar pathogenesis. We report on a 67-year-old Caucasian woman with a history of NL on the anterior shins that later developed lesions of GA on the breasts, trunk, and wrist. We also review the literature and discuss the characteristics of patients with concomitant GA and NL.

No MeSH data available.


Related in: MedlinePlus

Right upper extremity with erythematous plaques and annular plaques. (Copyright: ©2015 Rupley et al.)
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f2c-dp0501a03: Right upper extremity with erythematous plaques and annular plaques. (Copyright: ©2015 Rupley et al.)

Mentions: The patient was seen for follow-up and stated she began developing new lesions on her thighs, trunk upper arm, and wrists (Figure 2A, B, C, D). The lesions appeared as erythematous papules brown plaques, some with a central clearing. Punch biopsy of the chest was performed and revealed discrete areas of palisading histiocytes surrounding collections of mucin with perivascular lymphocytes, suggestive of interstitial granuloma annulare (Figure 3A, B, C).


Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature.

Rupley KA, Riahi RR, Hooper DO - Dermatol Pract Concept (2015)

Right upper extremity with erythematous plaques and annular plaques. (Copyright: ©2015 Rupley et al.)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4325686&req=5

f2c-dp0501a03: Right upper extremity with erythematous plaques and annular plaques. (Copyright: ©2015 Rupley et al.)
Mentions: The patient was seen for follow-up and stated she began developing new lesions on her thighs, trunk upper arm, and wrists (Figure 2A, B, C, D). The lesions appeared as erythematous papules brown plaques, some with a central clearing. Punch biopsy of the chest was performed and revealed discrete areas of palisading histiocytes surrounding collections of mucin with perivascular lymphocytes, suggestive of interstitial granuloma annulare (Figure 3A, B, C).

Bottom Line: GA and NL are characterized histologically by areas of necrobiosis of collagen.We report on a 67-year-old Caucasian woman with a history of NL on the anterior shins that later developed lesions of GA on the breasts, trunk, and wrist.We also review the literature and discuss the characteristics of patients with concomitant GA and NL.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.

ABSTRACT
Granuloma annulare (GA) and necrobiosis lipoidica (NL) are granulomatous diseases of undetermined etiology. Rarely, both dermatoses have been reported to occur concomitantly in patients. GA and NL are characterized histologically by areas of necrobiosis of collagen. The two diseases share some common characteristics, which may suggest that these dermatoses could occur as a spectrum in some patients or possibly share a similar pathogenesis. We report on a 67-year-old Caucasian woman with a history of NL on the anterior shins that later developed lesions of GA on the breasts, trunk, and wrist. We also review the literature and discuss the characteristics of patients with concomitant GA and NL.

No MeSH data available.


Related in: MedlinePlus