Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study.
Bottom Line: Although some recent studies suggest that increasing concentrations of PFCs may decrease fecundity, divergence in the methodological approaches used to evaluate this association have prevented firm conclusions being reached.After adjustment for potential confounders, PFOA and PFHxS were associated with a 11 and 9% reduction in fecundability per one SD increase (FOR = 0.89; 95% CI 0.83-0.94; P < 0.001 for PFOA and FOR = 0.91; 95% CI 0.86-0.97; P = 0.002 for PFHxS), while no significant association was observed for PFOS (FOR = 0.96; 95% CI 0.91-1.02; P = 0.17).There are no conflicts of interest to declare.
Affiliation: Sainte-Justine University Hospital Research Centre, University of Montreal, Montreal, Canada email@example.com.Show MeSH
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Mentions: In this specific pregnancy-based retrospective TTP study, socio-demographic and lifestyle data, as well as biospecimens collected during the first trimester of pregnancy (6 to <14 weeks), from 1743 participants were analyzed. In MIREC, women were asked about the type of birth control they used before this pregnancy. If a method was indicated, women were then asked if they had stopped it before the pregnancy started or if there was a birth control failure. Women who answered that there was a birth control failure were excluded from the present analysis (Fig. 1). Sixteen patients who became pregnant with sperm donation, 3 with egg donation and 15 whose male partners required some infertility treatment were also excluded.Figure 1
Affiliation: Sainte-Justine University Hospital Research Centre, University of Montreal, Montreal, Canada firstname.lastname@example.org.