Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults.
Bottom Line: Higher mean SBP was associated with lower white matter integrity in uncinate and superior lateral fasciculi bilaterally, independent of age, stroke history, antihypertensive medication use (odds ratio of having white matter hyperintensities greater than or equal to the median for 10mm Hg of SBP = 10.4, 95% confidence interval = 10.2-10.6, P = 0.0001; standardized beta for fractional anisotropy = -13.54, SE = 4.58, P = 0.003).Associations with gray matter measures were not significant.Whether lowering and/or stabilizing SBP levels in very old adults without a remarkable cardiovascular history would have neuroprotective effects and reduce dementia risk needs further study.
Affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; firstname.lastname@example.org.Show MeSH
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Mentions: Group-based trajectory models25,26 using PROC TRAJ in SAS9 were applied to identify SBP trajectories. Groups were chosen using the Bayesian information criteria without a priori assumptions regarding the order of the trajectory curves as long as the estimated probabilities of group membership were significant and the time coefficients were of statistical significance. Five groups were identified (Figure 1): 3 had stable SBP levels, and 2 had higher and varying levels in the years preceding neuroimaging.
Affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; email@example.com.