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Predictive factors of central lymph node metastasis in papillary thyroid carcinoma.

Ahn BH, Kim JR, Jeong HC, Lee JS, Chang ES, Kim YH - Ann Surg Treat Res (2015)

Bottom Line: The rate of CLN metastasis was considerably higher in cases of younger patients (<45 years old) (P < 0.001; odds ratio [OR], 2.357) and of a maximal tumor size greater than 1 cm (P < 0.001; OR, 3.165).Younger age (<45 years old) and maximal tumor size greater than 1 cm were independent risk factors for CLN metastasis.Maximal tumor size greater than 1 cm and presence of ipsilateral CLN macrometastasis were independent risk factors for contralateral CLN metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Chungnam National University College of Medicine, Daejeon, Korea.

ABSTRACT

Purpose: The aim of this study was to evaluate the correlation between central lymph node (CLN) metastasis and clinicopathologic characteristics of papillary thyroid cancer (PTC). In addition, we investigated the incidence and risk factors for contralateral CLN metastasis in unilateral PTC. This study suggests the appropriate surgical extent for CLN dissection.

Methods: A prospective study of 500 patients with PTC who underwent total thyroidectomy and prophylactic bilateral CLN dissection was conducted.

Results: Of 500 patients, 255 had CLN metastases. The rate of CLN metastasis was considerably higher in cases of younger patients (<45 years old) (P < 0.001; odds ratio [OR], 2.357) and of a maximal tumor size greater than 1 cm (P < 0.001; OR, 3.165). Ipsilateral CLN metastasis was detected in 83.1% of cases (133/160) of unilateral PTC, only contralateral CLN metastases in 3.7% of cases (6/160), and bilateral CLN metastases in 13.1% of cases (21/160). The rate of contralateral CLN metastasis was considerably higher in cases of PTC with a large tumor size (≥1 cm) (P = 0.019; OR, 4.440) and with ipsilateral CLN metastasis (P = 0.047; OR, 2.613).

Conclusion: Younger age (<45 years old) and maximal tumor size greater than 1 cm were independent risk factors for CLN metastasis. Maximal tumor size greater than 1 cm and presence of ipsilateral CLN macrometastasis were independent risk factors for contralateral CLN metastasis. Therefore, both CLN dissections should be considered for unilateral PTC with a maximal tumor size greater than 1 cm or presence of ipsilateral CLN macrometastasis.

No MeSH data available.


Related in: MedlinePlus

Trend of central lymph node (CLN) metastasis in unilateral papillary thyroid cancer (PTC). CLND, central lymph node dissection.
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Related In: Results  -  Collection

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Figure 1: Trend of central lymph node (CLN) metastasis in unilateral papillary thyroid cancer (PTC). CLND, central lymph node dissection.

Mentions: The trend of CLN metastasis in unilateral PTC patients is depicted in Fig. 1. Of 341 patients with unilateral PTC, 160 had CLN metastases. We excluded isthmic PTC in patients with unilateral PTC analysis.


Predictive factors of central lymph node metastasis in papillary thyroid carcinoma.

Ahn BH, Kim JR, Jeong HC, Lee JS, Chang ES, Kim YH - Ann Surg Treat Res (2015)

Trend of central lymph node (CLN) metastasis in unilateral papillary thyroid cancer (PTC). CLND, central lymph node dissection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325652&req=5

Figure 1: Trend of central lymph node (CLN) metastasis in unilateral papillary thyroid cancer (PTC). CLND, central lymph node dissection.
Mentions: The trend of CLN metastasis in unilateral PTC patients is depicted in Fig. 1. Of 341 patients with unilateral PTC, 160 had CLN metastases. We excluded isthmic PTC in patients with unilateral PTC analysis.

Bottom Line: The rate of CLN metastasis was considerably higher in cases of younger patients (<45 years old) (P < 0.001; odds ratio [OR], 2.357) and of a maximal tumor size greater than 1 cm (P < 0.001; OR, 3.165).Younger age (<45 years old) and maximal tumor size greater than 1 cm were independent risk factors for CLN metastasis.Maximal tumor size greater than 1 cm and presence of ipsilateral CLN macrometastasis were independent risk factors for contralateral CLN metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Chungnam National University College of Medicine, Daejeon, Korea.

ABSTRACT

Purpose: The aim of this study was to evaluate the correlation between central lymph node (CLN) metastasis and clinicopathologic characteristics of papillary thyroid cancer (PTC). In addition, we investigated the incidence and risk factors for contralateral CLN metastasis in unilateral PTC. This study suggests the appropriate surgical extent for CLN dissection.

Methods: A prospective study of 500 patients with PTC who underwent total thyroidectomy and prophylactic bilateral CLN dissection was conducted.

Results: Of 500 patients, 255 had CLN metastases. The rate of CLN metastasis was considerably higher in cases of younger patients (<45 years old) (P < 0.001; odds ratio [OR], 2.357) and of a maximal tumor size greater than 1 cm (P < 0.001; OR, 3.165). Ipsilateral CLN metastasis was detected in 83.1% of cases (133/160) of unilateral PTC, only contralateral CLN metastases in 3.7% of cases (6/160), and bilateral CLN metastases in 13.1% of cases (21/160). The rate of contralateral CLN metastasis was considerably higher in cases of PTC with a large tumor size (≥1 cm) (P = 0.019; OR, 4.440) and with ipsilateral CLN metastasis (P = 0.047; OR, 2.613).

Conclusion: Younger age (<45 years old) and maximal tumor size greater than 1 cm were independent risk factors for CLN metastasis. Maximal tumor size greater than 1 cm and presence of ipsilateral CLN macrometastasis were independent risk factors for contralateral CLN metastasis. Therefore, both CLN dissections should be considered for unilateral PTC with a maximal tumor size greater than 1 cm or presence of ipsilateral CLN macrometastasis.

No MeSH data available.


Related in: MedlinePlus