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Case characteristics, hyperacute treatment, and outcome information from the clinical research center for stroke-fifth division registry in South Korea.

Kim BJ, Park JM, Kang K, Lee SJ, Ko Y, Kim JG, Cha JK, Kim DH, Nah HW, Han MK, Park TH, Park SS, Lee KB, Lee J, Hong KS, Cho YJ, Lee BC, Yu KH, Oh MS, Kim DE, Ryu WS, Cho KH, Kim JT, Choi JC, Kim WJ, Shin DI, Yeo MJ, Sohn SI, Hong JH, Lee J, Lee JS, Yoon BW, Bae HJ - J Stroke (2015)

Bottom Line: The rate of symptomatic hemorrhagic transformation (HT) was 7%, and that of any HT was 27% among recanalization-treated cases.Early neurological deterioration occurred in 15% of cases and were associated with longer length of stay and poorer 3-month outcomes.The above findings will be compared with other Asian and US registry data in this article.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Characteristics of stroke cases, acute stroke care, and outcomes after stroke differ according to geographical and cultural background. To provide epidemiological and clinical data on stroke care in South Korea, we analyzed a prospective multicenter clinical stroke registry, the Clinical Research Center for Stroke-Fifth Division (CRCS-5). Patients were 58% male with a mean age of 67.2±12.9 years and median National Institutes of Health Stroke Scale score of 3 [1-8] points. Over the 6 years of operation, temporal trends were documented including increasing utilization of recanalization treatment with shorter onset-to-arrival delay and decremental length of stay. Acute recanalization treatment was performed in 12.7% of cases with endovascular treatment utilized in 36%, but the proportion of endovascular recanalization varied across centers. Door-to-IV alteplase delay had a median of 45 [33-68] min. The rate of symptomatic hemorrhagic transformation (HT) was 7%, and that of any HT was 27% among recanalization-treated cases. Early neurological deterioration occurred in 15% of cases and were associated with longer length of stay and poorer 3-month outcomes. The proportion of mRS scores of 0-1 was 42% on discharge, 50% at 3 months, and 55% at 1 year after the index stroke. Recurrent stroke up to 1 year occurred in 4.5% of patients; the rate was higher among older individuals and those with neurologically severe deficits. The above findings will be compared with other Asian and US registry data in this article.

No MeSH data available.


Related in: MedlinePlus

CRCS-5 centers and their locations.
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Figure 1: CRCS-5 centers and their locations.

Mentions: The CRCS-5 registry was initiated in April 2008 with nine hospitals. In April 2008, participating centers were mostly located in the Seoul metropolitan area, with one from the central area and one from the southeastern area of South Korea. Such geographical preponderance was slowly alleviated with the participation of Chonnam National University (located in the southwestern part of South Korea) and Dongguk University Ilsan Hospital in January 2011. Jeju National University Hospital joined the CRCS-5 registry in October 2011, and in February 2013, two hospitals joined the CRCS-5 registry-Chungbuk National University Hospital and Ulsan University Hospital. Keimyung University Dongsan Medical Cetner, located in Daegu, began enrolling acute stroke cases in the CRCS-5 registry in May 2014. As of September 2014, 15 hospitals, covering most areas of South Korea, are actively registering stroke cases in the CRCS-5 registry (Figure 1).


Case characteristics, hyperacute treatment, and outcome information from the clinical research center for stroke-fifth division registry in South Korea.

Kim BJ, Park JM, Kang K, Lee SJ, Ko Y, Kim JG, Cha JK, Kim DH, Nah HW, Han MK, Park TH, Park SS, Lee KB, Lee J, Hong KS, Cho YJ, Lee BC, Yu KH, Oh MS, Kim DE, Ryu WS, Cho KH, Kim JT, Choi JC, Kim WJ, Shin DI, Yeo MJ, Sohn SI, Hong JH, Lee J, Lee JS, Yoon BW, Bae HJ - J Stroke (2015)

CRCS-5 centers and their locations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4325643&req=5

Figure 1: CRCS-5 centers and their locations.
Mentions: The CRCS-5 registry was initiated in April 2008 with nine hospitals. In April 2008, participating centers were mostly located in the Seoul metropolitan area, with one from the central area and one from the southeastern area of South Korea. Such geographical preponderance was slowly alleviated with the participation of Chonnam National University (located in the southwestern part of South Korea) and Dongguk University Ilsan Hospital in January 2011. Jeju National University Hospital joined the CRCS-5 registry in October 2011, and in February 2013, two hospitals joined the CRCS-5 registry-Chungbuk National University Hospital and Ulsan University Hospital. Keimyung University Dongsan Medical Cetner, located in Daegu, began enrolling acute stroke cases in the CRCS-5 registry in May 2014. As of September 2014, 15 hospitals, covering most areas of South Korea, are actively registering stroke cases in the CRCS-5 registry (Figure 1).

Bottom Line: The rate of symptomatic hemorrhagic transformation (HT) was 7%, and that of any HT was 27% among recanalization-treated cases.Early neurological deterioration occurred in 15% of cases and were associated with longer length of stay and poorer 3-month outcomes.The above findings will be compared with other Asian and US registry data in this article.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Characteristics of stroke cases, acute stroke care, and outcomes after stroke differ according to geographical and cultural background. To provide epidemiological and clinical data on stroke care in South Korea, we analyzed a prospective multicenter clinical stroke registry, the Clinical Research Center for Stroke-Fifth Division (CRCS-5). Patients were 58% male with a mean age of 67.2±12.9 years and median National Institutes of Health Stroke Scale score of 3 [1-8] points. Over the 6 years of operation, temporal trends were documented including increasing utilization of recanalization treatment with shorter onset-to-arrival delay and decremental length of stay. Acute recanalization treatment was performed in 12.7% of cases with endovascular treatment utilized in 36%, but the proportion of endovascular recanalization varied across centers. Door-to-IV alteplase delay had a median of 45 [33-68] min. The rate of symptomatic hemorrhagic transformation (HT) was 7%, and that of any HT was 27% among recanalization-treated cases. Early neurological deterioration occurred in 15% of cases and were associated with longer length of stay and poorer 3-month outcomes. The proportion of mRS scores of 0-1 was 42% on discharge, 50% at 3 months, and 55% at 1 year after the index stroke. Recurrent stroke up to 1 year occurred in 4.5% of patients; the rate was higher among older individuals and those with neurologically severe deficits. The above findings will be compared with other Asian and US registry data in this article.

No MeSH data available.


Related in: MedlinePlus