The melanocyte lineage in development and disease.
Bottom Line: Melanocyte development provides an excellent model for studying more complex developmental processes.In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches.This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.
Affiliation: MRC Human Genetics Unit and.Show MeSH
Related in: MedlinePlus
Mentions: Returning to mammalian melanocytes, once melanocyte development and migration are established, how do animals maintain, alter or regenerate pigmentation in adult life? Evidence from multiple species points to a reservoir of MSCs that can be called upon when needed to re-pigment the skin and/or hair (Fig. 3). The identification and potential manipulation of MSCs might hold therapeutic value for pigmentation disorders, wounding and melanoma.Fig. 3.