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Spitz nevi in the classic histopathological pattern--lamb in wolf`s clothing.

Verardino GC, Rochael MC - An Bras Dermatol (2015 Jan-Feb)

Bottom Line: Kamino bodies were found in eight cases (25%).Atypical melanocytes were present in 18 cases (56%).Mitoses were present in 11 cases (34%).

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal Fluminense, Niterói, RJ, Brazil.

ABSTRACT
Spitz nevus is a benign melanocytic lesion and also one of the main differential diagnosis of melanoma. A descriptive and retrospective study of surgical specimens from patients with a diagnosis of Spitz nevus was conducted at two institutions in Niterói - RJ. 32 cases were analyzed. The most frequent histological subtype was compound (60 %), with a predominance of epithelioid cells (17 cases - 53%). Pagetoid spread was observed in 21 cases (68%). Maturation of melanocytes was present in 13 cases (81%). Kamino bodies were found in eight cases (25%). Atypical melanocytes were present in 18 cases (56%). Mitoses were present in 11 cases (34%). Detailed knowledge of the classical form of Spitz nevi is essential for the differential diagnosis with melanoma. However, no single criterium is definitive in the differential diagnosis between Spitz nevus and melanoma.

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Lack of maturation. Atypical melanocytes with pleomorphism, anisocoria,cariomegaly and eosinophilic nucleoli (HE, original magnification - 400x)
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f05: Lack of maturation. Atypical melanocytes with pleomorphism, anisocoria,cariomegaly and eosinophilic nucleoli (HE, original magnification - 400x)


Spitz nevi in the classic histopathological pattern--lamb in wolf`s clothing.

Verardino GC, Rochael MC - An Bras Dermatol (2015 Jan-Feb)

Lack of maturation. Atypical melanocytes with pleomorphism, anisocoria,cariomegaly and eosinophilic nucleoli (HE, original magnification - 400x)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4323702&req=5

f05: Lack of maturation. Atypical melanocytes with pleomorphism, anisocoria,cariomegaly and eosinophilic nucleoli (HE, original magnification - 400x)
Bottom Line: Kamino bodies were found in eight cases (25%).Atypical melanocytes were present in 18 cases (56%).Mitoses were present in 11 cases (34%).

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal Fluminense, Niterói, RJ, Brazil.

ABSTRACT
Spitz nevus is a benign melanocytic lesion and also one of the main differential diagnosis of melanoma. A descriptive and retrospective study of surgical specimens from patients with a diagnosis of Spitz nevus was conducted at two institutions in Niterói - RJ. 32 cases were analyzed. The most frequent histological subtype was compound (60 %), with a predominance of epithelioid cells (17 cases - 53%). Pagetoid spread was observed in 21 cases (68%). Maturation of melanocytes was present in 13 cases (81%). Kamino bodies were found in eight cases (25%). Atypical melanocytes were present in 18 cases (56%). Mitoses were present in 11 cases (34%). Detailed knowledge of the classical form of Spitz nevi is essential for the differential diagnosis with melanoma. However, no single criterium is definitive in the differential diagnosis between Spitz nevus and melanoma.

Show MeSH
Related in: MedlinePlus