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Targeted temperature management in brain protection: An evidence-based review.

Tripathy S, Mahapatra AK - Indian J Anaesth (2015)

Bottom Line: Targeted temperature management (TTM) for neuroprotection involves maintaining the temperature of the brain at predetermined levels by various techniques.This review briefly discusses the evidence base for TTM.The focus is on various areas of application for neuroprotection, the practical issues pertaining to TTM implementation, the recent data that support it and the present areas of controversy.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma and Emergency Medicine, Division of Anesthesia and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

ABSTRACT
Targeted temperature management (TTM) for neuroprotection involves maintaining the temperature of the brain at predetermined levels by various techniques. It is aimed at avoiding the harmful effects of hyperthermia on the brain and at exploiting the protective effects of lower tissue temperature. There has been an explosion in the use of TTM for neuroprotection in a variety of clinical scenarios apart from the commonly accepted fields of resuscitation and ischaemic, hypoxic encephalopathy. This review briefly discusses the evidence base for TTM. The focus is on various areas of application for neuroprotection, the practical issues pertaining to TTM implementation, the recent data that support it and the present areas of controversy.

No MeSH data available.


Related in: MedlinePlus

Neuroprotective mechanism of hypothermia – bold arrows depict the multiple stages at which hypothermia decreases the effects of the primary insult
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Figure 1: Neuroprotective mechanism of hypothermia – bold arrows depict the multiple stages at which hypothermia decreases the effects of the primary insult

Mentions: Cooling has been shown to reduce primary injury and prevent secondary injury in animal models of brain insult and certain clinical settings.[3] Hypothermia affects pathways leading to excitotoxicity, apoptosis, inflammation and free radical production, as well as blood flow, metabolism and blood-brain barrier integrity. Hypothermia may also influence neurogenesis, gliogenesis and angiogenesis following the injury [Figure 1]. It is likely that no single factor can explain the neuroprotection provided by hypothermia, but understanding its myriad effects may shed light on its neuroprotective mechanisms.[4]


Targeted temperature management in brain protection: An evidence-based review.

Tripathy S, Mahapatra AK - Indian J Anaesth (2015)

Neuroprotective mechanism of hypothermia – bold arrows depict the multiple stages at which hypothermia decreases the effects of the primary insult
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4322114&req=5

Figure 1: Neuroprotective mechanism of hypothermia – bold arrows depict the multiple stages at which hypothermia decreases the effects of the primary insult
Mentions: Cooling has been shown to reduce primary injury and prevent secondary injury in animal models of brain insult and certain clinical settings.[3] Hypothermia affects pathways leading to excitotoxicity, apoptosis, inflammation and free radical production, as well as blood flow, metabolism and blood-brain barrier integrity. Hypothermia may also influence neurogenesis, gliogenesis and angiogenesis following the injury [Figure 1]. It is likely that no single factor can explain the neuroprotection provided by hypothermia, but understanding its myriad effects may shed light on its neuroprotective mechanisms.[4]

Bottom Line: Targeted temperature management (TTM) for neuroprotection involves maintaining the temperature of the brain at predetermined levels by various techniques.This review briefly discusses the evidence base for TTM.The focus is on various areas of application for neuroprotection, the practical issues pertaining to TTM implementation, the recent data that support it and the present areas of controversy.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma and Emergency Medicine, Division of Anesthesia and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

ABSTRACT
Targeted temperature management (TTM) for neuroprotection involves maintaining the temperature of the brain at predetermined levels by various techniques. It is aimed at avoiding the harmful effects of hyperthermia on the brain and at exploiting the protective effects of lower tissue temperature. There has been an explosion in the use of TTM for neuroprotection in a variety of clinical scenarios apart from the commonly accepted fields of resuscitation and ischaemic, hypoxic encephalopathy. This review briefly discusses the evidence base for TTM. The focus is on various areas of application for neuroprotection, the practical issues pertaining to TTM implementation, the recent data that support it and the present areas of controversy.

No MeSH data available.


Related in: MedlinePlus