Limits...
Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats.

Cho HS, Baek DJ, Baek SS - J Exerc Nutrition Biochem (2014)

Bottom Line: Dopamine D2 receptor activation decreases the excitability of dopamine neurons, as well as the release of dopamine.Open field task and elevated-plus maze task were used in the evaluation of hyperactivity and impulsivity, respectively.We thus showed that exercise effectively alleviates ADHD-induced symptoms through enhancing dopamine D2 expression in the brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurobehavioral disorder that is characterized by hyperactivity, inattention, and impulsivity. It is commonly believed that the symptoms of ADHD are closely associated with hypo-function of the dopamine system. Dopamine D2 receptor activation decreases the excitability of dopamine neurons, as well as the release of dopamine. Physical exercise is known to improve structural and functional impairments in neuropsychiatric disorders. We investigated the therapeutic effect of exercise on ADHD.

Methods: Open field task and elevated-plus maze task were used in the evaluation of hyperactivity and impulsivity, respectively. Dopamine D2 receptor expression in the substantia nigra and striatum were evaluated by western blotting.

Results: The present results indicated that ADHD rats showed hyperactivity and impulsivity. Dopamine D2 receptor expression in the substantia nigra and striatum were increased in ADHD rats. Exercise alleviated hyperactivity and impulsivity in ADHD rats. Furthermore, dopamine D2 receptor expression in ADHD rats was also decreased by exercise.

Conclusion: We thus showed that exercise effectively alleviates ADHD-induced symptoms through enhancing dopamine D2 expression in the brain.

No MeSH data available.


Related in: MedlinePlus

Results of the behavioral test for impulsivity in the elevated plus maze task. The results are presented as the means ± standard error of the mean. (a) Time spent in open arms, (b) Number of arm entries in open arms; (A) Control group, (B) ADHD group, (C) ADHD & Exercise group, (D) ADHD & Methylphenidate-treated group. * represents P < 0.05 compared to Control group. # represents P < 0.05 compared to the ADHD group.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4322029&req=5

f2-jenb-18-4-379: Results of the behavioral test for impulsivity in the elevated plus maze task. The results are presented as the means ± standard error of the mean. (a) Time spent in open arms, (b) Number of arm entries in open arms; (A) Control group, (B) ADHD group, (C) ADHD & Exercise group, (D) ADHD & Methylphenidate-treated group. * represents P < 0.05 compared to Control group. # represents P < 0.05 compared to the ADHD group.

Mentions: Impulsivity was assessed using the elevated plus maze task. The latency of staying in the open arm in the elevated plus maze task was presented in Fig. 2. The latency time in the open arm was 52.23 ± 9.58 in the Control group, and 189.35 ± 20.68 in the ADHD group, 154.21 ± 8.02 in the ADHD & Exercise group, and 143.96 ± 15.29 in the ADHD & Methylphenidate-treated group. The number of entrances into the open arm was 1.71 ± 0.81 in the Control group, 6.91 ± 0.93 in the ADHD group, 5.79 ± 0.58 in the ADHD & Exercise group, and 5.63 ± 0.86 in the ADHD & Methylphenidate-treated group.


Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats.

Cho HS, Baek DJ, Baek SS - J Exerc Nutrition Biochem (2014)

Results of the behavioral test for impulsivity in the elevated plus maze task. The results are presented as the means ± standard error of the mean. (a) Time spent in open arms, (b) Number of arm entries in open arms; (A) Control group, (B) ADHD group, (C) ADHD & Exercise group, (D) ADHD & Methylphenidate-treated group. * represents P < 0.05 compared to Control group. # represents P < 0.05 compared to the ADHD group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4322029&req=5

f2-jenb-18-4-379: Results of the behavioral test for impulsivity in the elevated plus maze task. The results are presented as the means ± standard error of the mean. (a) Time spent in open arms, (b) Number of arm entries in open arms; (A) Control group, (B) ADHD group, (C) ADHD & Exercise group, (D) ADHD & Methylphenidate-treated group. * represents P < 0.05 compared to Control group. # represents P < 0.05 compared to the ADHD group.
Mentions: Impulsivity was assessed using the elevated plus maze task. The latency of staying in the open arm in the elevated plus maze task was presented in Fig. 2. The latency time in the open arm was 52.23 ± 9.58 in the Control group, and 189.35 ± 20.68 in the ADHD group, 154.21 ± 8.02 in the ADHD & Exercise group, and 143.96 ± 15.29 in the ADHD & Methylphenidate-treated group. The number of entrances into the open arm was 1.71 ± 0.81 in the Control group, 6.91 ± 0.93 in the ADHD group, 5.79 ± 0.58 in the ADHD & Exercise group, and 5.63 ± 0.86 in the ADHD & Methylphenidate-treated group.

Bottom Line: Dopamine D2 receptor activation decreases the excitability of dopamine neurons, as well as the release of dopamine.Open field task and elevated-plus maze task were used in the evaluation of hyperactivity and impulsivity, respectively.We thus showed that exercise effectively alleviates ADHD-induced symptoms through enhancing dopamine D2 expression in the brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurobehavioral disorder that is characterized by hyperactivity, inattention, and impulsivity. It is commonly believed that the symptoms of ADHD are closely associated with hypo-function of the dopamine system. Dopamine D2 receptor activation decreases the excitability of dopamine neurons, as well as the release of dopamine. Physical exercise is known to improve structural and functional impairments in neuropsychiatric disorders. We investigated the therapeutic effect of exercise on ADHD.

Methods: Open field task and elevated-plus maze task were used in the evaluation of hyperactivity and impulsivity, respectively. Dopamine D2 receptor expression in the substantia nigra and striatum were evaluated by western blotting.

Results: The present results indicated that ADHD rats showed hyperactivity and impulsivity. Dopamine D2 receptor expression in the substantia nigra and striatum were increased in ADHD rats. Exercise alleviated hyperactivity and impulsivity in ADHD rats. Furthermore, dopamine D2 receptor expression in ADHD rats was also decreased by exercise.

Conclusion: We thus showed that exercise effectively alleviates ADHD-induced symptoms through enhancing dopamine D2 expression in the brain.

No MeSH data available.


Related in: MedlinePlus