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The ACTN3 R577X variant in sprint and strength performance.

Kim H, Song KH, Kim CH - J Exerc Nutrition Biochem (2014)

Bottom Line: ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854).Genetic associations were evaluated by chi-squire test or Fisher's exact test.When the power-oriented group was divided into strength-oriented and speed-oriented groups, no significant difference in the ACTN3 XX genotype was found between the strength-oriented athletes and the controls (15.9% versus 19.1%, P < 0.262).

View Article: PubMed Central - PubMed

Affiliation: Korea National University of Education, Chungcheongbuk-do, Korea.

ABSTRACT

Purpose: The aim of this study is to examine the association between the distribution of ACTN3 genotypes and alleles in power, speed, and strength-oriented athletics.

Methods: ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854).

Results: Genetic associations were evaluated by chi-squire test or Fisher's exact test. In the power-oriented group composed of sprinters and strength athletes, the frequency of the XX genotype was significantly underrepresented (11.6%) in comparison to its representation in the control group (11.6% versus 19.1%, P < 0.05). When the power-oriented group was divided into strength-oriented and speed-oriented groups, no significant difference in the ACTN3 XX genotype was found between the strength-oriented athletes and the controls (15.9% versus 19.1%, P < 0.262). Only the speed-oriented athletes showed significant differences in the frequency distributions of the ACTN3 XX genotype (6.9% versus 19.1%, P < 0.05) from that of the controls.

Conclusion: The ACTN3 genotype seems to mainly affect sports performance and especially speed.

No MeSH data available.


Distribution of α-actinin-3 expression and non-expression genotype in the top-level strength-oriented athletes, speed-oriented athletes, and controls* means significantly different in genotype distribution from the control at P < 0.05
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f1-jenb-18-4-347: Distribution of α-actinin-3 expression and non-expression genotype in the top-level strength-oriented athletes, speed-oriented athletes, and controls* means significantly different in genotype distribution from the control at P < 0.05

Mentions: To test the association of power types (strength and speed performance) with the ACTN3 genotype, the power-oriented group was divided into the strength-oriented group (the toplevel weightlifters) and the speed-oriented group (the top-level sprinters). Both of them were in HWE (χ2[df=1] = 1.758 for speed-oriented athletes, χ2[df=1] = 0.210 for strength-oriented athletes; P > 0.10). As shown in Table 1, no statistical differences in the ACTN3 genotype and allele distributions were found between the strength-oriented athletes and the controls (χ2[df=2] = 2.682, P < 0.262 for genotype; χ2[df=1] = 2.022, P = 0.155 for allele). Only the speed-oriented athletes showed significant differences in the frequency distributions of the ACTN3 genotype (Fisher’s Exact Test = 7.252, P < 0.05) and the allele (χ2[df=1] = 6.200, P < 0.05) from that of the controls. In Fig. 1, the frequency of the α-actinin-3 non-expression genotype (XX) was significantly reduced while the frequency of the α-actinin-3 expression genotype (RR + RX) was significantly increased in the speed-oriented athletes compared with the controls (Fisher’s Exact Test = 5.395, P < 0.05; Fig. 1). No significant difference in the α -actinin-3 expression genotype distribution was found in the strength-oriented athletes compared with the controls (χ2[df=1] = 0.396, P < 0.529).


The ACTN3 R577X variant in sprint and strength performance.

Kim H, Song KH, Kim CH - J Exerc Nutrition Biochem (2014)

Distribution of α-actinin-3 expression and non-expression genotype in the top-level strength-oriented athletes, speed-oriented athletes, and controls* means significantly different in genotype distribution from the control at P < 0.05
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4322025&req=5

f1-jenb-18-4-347: Distribution of α-actinin-3 expression and non-expression genotype in the top-level strength-oriented athletes, speed-oriented athletes, and controls* means significantly different in genotype distribution from the control at P < 0.05
Mentions: To test the association of power types (strength and speed performance) with the ACTN3 genotype, the power-oriented group was divided into the strength-oriented group (the toplevel weightlifters) and the speed-oriented group (the top-level sprinters). Both of them were in HWE (χ2[df=1] = 1.758 for speed-oriented athletes, χ2[df=1] = 0.210 for strength-oriented athletes; P > 0.10). As shown in Table 1, no statistical differences in the ACTN3 genotype and allele distributions were found between the strength-oriented athletes and the controls (χ2[df=2] = 2.682, P < 0.262 for genotype; χ2[df=1] = 2.022, P = 0.155 for allele). Only the speed-oriented athletes showed significant differences in the frequency distributions of the ACTN3 genotype (Fisher’s Exact Test = 7.252, P < 0.05) and the allele (χ2[df=1] = 6.200, P < 0.05) from that of the controls. In Fig. 1, the frequency of the α-actinin-3 non-expression genotype (XX) was significantly reduced while the frequency of the α-actinin-3 expression genotype (RR + RX) was significantly increased in the speed-oriented athletes compared with the controls (Fisher’s Exact Test = 5.395, P < 0.05; Fig. 1). No significant difference in the α -actinin-3 expression genotype distribution was found in the strength-oriented athletes compared with the controls (χ2[df=1] = 0.396, P < 0.529).

Bottom Line: ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854).Genetic associations were evaluated by chi-squire test or Fisher's exact test.When the power-oriented group was divided into strength-oriented and speed-oriented groups, no significant difference in the ACTN3 XX genotype was found between the strength-oriented athletes and the controls (15.9% versus 19.1%, P < 0.262).

View Article: PubMed Central - PubMed

Affiliation: Korea National University of Education, Chungcheongbuk-do, Korea.

ABSTRACT

Purpose: The aim of this study is to examine the association between the distribution of ACTN3 genotypes and alleles in power, speed, and strength-oriented athletics.

Methods: ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854).

Results: Genetic associations were evaluated by chi-squire test or Fisher's exact test. In the power-oriented group composed of sprinters and strength athletes, the frequency of the XX genotype was significantly underrepresented (11.6%) in comparison to its representation in the control group (11.6% versus 19.1%, P < 0.05). When the power-oriented group was divided into strength-oriented and speed-oriented groups, no significant difference in the ACTN3 XX genotype was found between the strength-oriented athletes and the controls (15.9% versus 19.1%, P < 0.262). Only the speed-oriented athletes showed significant differences in the frequency distributions of the ACTN3 XX genotype (6.9% versus 19.1%, P < 0.05) from that of the controls.

Conclusion: The ACTN3 genotype seems to mainly affect sports performance and especially speed.

No MeSH data available.