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Synergistic impaired effect between smoking and manganese dust exposure on pulmonary ventilation function in Guangxi manganese-exposed workers healthy cohort (GXMEWHC).

Wang F, Zou Y, Shen Y, Zhong Y, Lv Y, Huang D, Chen K, Li Q, Qing L, Xia B, Su C, Ma S, Yang X - PLoS ONE (2015)

Bottom Line: No significant effect of Mn dust exposure on the pulmonary function was found in the female workers (all p>0.05).In particular, among the exposed subjects smokers had a statistically significant decrease in lung function compared with non-smokers and the reduction in FVC% predicted, MMEF and MMEF% predicted was 1.0%, 210 mL/s, and 4.9%, respectively (p<0.05).Partial correlation analysis showed that there was also negative correlation between Mn-CEI and decreased changes in MMEF (r = -0.159, p = 0.018) and also MMEF% predicted (r = -0.163, p = 0.015).

View Article: PubMed Central - PubMed

Affiliation: Department of occupational health and environmental health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.

ABSTRACT

Purpose: The aims of this study were to investigate the effects of manganese (Mn) dust exposure on lung functions and evaluate the potential synergistic effect between smoking and Mn dust exposure among refinery workers.

Methods: A retrospective study including 1658 workers in a ferromanganese refinery was conducted, with subjects who were from the Guangxi manganese-exposed workers healthy cohort (GXMEWHC). Based on the Mn manganese cumulative exposure index (Mn-CEI), all subjects were divided into the low exposure group (n = 682) and the high exposure group (n = 976). A pulmonary function test was performed using an electronic spirometer, including the values and percentages of FVC, FEV1, FEV1/FVC, MMEF, PEFR, MVV, respectively.

Results: No significant effect of Mn dust exposure on the pulmonary function was found in the female workers (all p>0.05). However, there was an obvious decrease in the male workers in the high exposure group compared with those in the low exposure group (FVC -60 ml, FEV1 -120 ml, MMEF -260 ml/s, MVV -5.06 L, all p<0.05). In the high exposure group, the reduction in FVC% predicted, MMEF and MMEF% predicted was 1.0%, 210 mL/s, and 4.9%, respectively. In particular, among the exposed subjects smokers had a statistically significant decrease in lung function compared with non-smokers and the reduction in FVC% predicted, MMEF and MMEF% predicted was 1.0%, 210 mL/s, and 4.9%, respectively (p<0.05). Partial correlation analysis showed that there was also negative correlation between Mn-CEI and decreased changes in MMEF (r = -0.159, p = 0.018) and also MMEF% predicted (r = -0.163, p = 0.015).

Conclusions: Mn dust can impair the pulmonary ventilation function of male workers but not females, and individual smoking habits and manganese exposure had a synergistic effect on the lung function decrease.

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Related in: MedlinePlus

Correlation of maximal med-expiratory flow curve (MMEF) and the manganese cumulative exposure index (Mn-CEI) in male workers among high exposure group.Data were analyzed by partial correlation, r = -0.159, p<0.01.
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pone.0116558.g001: Correlation of maximal med-expiratory flow curve (MMEF) and the manganese cumulative exposure index (Mn-CEI) in male workers among high exposure group.Data were analyzed by partial correlation, r = -0.159, p<0.01.

Mentions: In the correlation analysis, a decreased linear trend of MMEF was found in the exposed subjects with the increased dose of Mn-CEI in the scatter diagram, and a significant negative correlation between MMEF and CEI (r = -0.159, p<0.05) was shown among smoking workers in high exposure group, as shown in Fig. 1.


Synergistic impaired effect between smoking and manganese dust exposure on pulmonary ventilation function in Guangxi manganese-exposed workers healthy cohort (GXMEWHC).

Wang F, Zou Y, Shen Y, Zhong Y, Lv Y, Huang D, Chen K, Li Q, Qing L, Xia B, Su C, Ma S, Yang X - PLoS ONE (2015)

Correlation of maximal med-expiratory flow curve (MMEF) and the manganese cumulative exposure index (Mn-CEI) in male workers among high exposure group.Data were analyzed by partial correlation, r = -0.159, p<0.01.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321994&req=5

pone.0116558.g001: Correlation of maximal med-expiratory flow curve (MMEF) and the manganese cumulative exposure index (Mn-CEI) in male workers among high exposure group.Data were analyzed by partial correlation, r = -0.159, p<0.01.
Mentions: In the correlation analysis, a decreased linear trend of MMEF was found in the exposed subjects with the increased dose of Mn-CEI in the scatter diagram, and a significant negative correlation between MMEF and CEI (r = -0.159, p<0.05) was shown among smoking workers in high exposure group, as shown in Fig. 1.

Bottom Line: No significant effect of Mn dust exposure on the pulmonary function was found in the female workers (all p>0.05).In particular, among the exposed subjects smokers had a statistically significant decrease in lung function compared with non-smokers and the reduction in FVC% predicted, MMEF and MMEF% predicted was 1.0%, 210 mL/s, and 4.9%, respectively (p<0.05).Partial correlation analysis showed that there was also negative correlation between Mn-CEI and decreased changes in MMEF (r = -0.159, p = 0.018) and also MMEF% predicted (r = -0.163, p = 0.015).

View Article: PubMed Central - PubMed

Affiliation: Department of occupational health and environmental health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.

ABSTRACT

Purpose: The aims of this study were to investigate the effects of manganese (Mn) dust exposure on lung functions and evaluate the potential synergistic effect between smoking and Mn dust exposure among refinery workers.

Methods: A retrospective study including 1658 workers in a ferromanganese refinery was conducted, with subjects who were from the Guangxi manganese-exposed workers healthy cohort (GXMEWHC). Based on the Mn manganese cumulative exposure index (Mn-CEI), all subjects were divided into the low exposure group (n = 682) and the high exposure group (n = 976). A pulmonary function test was performed using an electronic spirometer, including the values and percentages of FVC, FEV1, FEV1/FVC, MMEF, PEFR, MVV, respectively.

Results: No significant effect of Mn dust exposure on the pulmonary function was found in the female workers (all p>0.05). However, there was an obvious decrease in the male workers in the high exposure group compared with those in the low exposure group (FVC -60 ml, FEV1 -120 ml, MMEF -260 ml/s, MVV -5.06 L, all p<0.05). In the high exposure group, the reduction in FVC% predicted, MMEF and MMEF% predicted was 1.0%, 210 mL/s, and 4.9%, respectively. In particular, among the exposed subjects smokers had a statistically significant decrease in lung function compared with non-smokers and the reduction in FVC% predicted, MMEF and MMEF% predicted was 1.0%, 210 mL/s, and 4.9%, respectively (p<0.05). Partial correlation analysis showed that there was also negative correlation between Mn-CEI and decreased changes in MMEF (r = -0.159, p = 0.018) and also MMEF% predicted (r = -0.163, p = 0.015).

Conclusions: Mn dust can impair the pulmonary ventilation function of male workers but not females, and individual smoking habits and manganese exposure had a synergistic effect on the lung function decrease.

Show MeSH
Related in: MedlinePlus